38 Questions
What is the purpose of primary platelet adhesion receptors?
What is the role of fibrin in the formation of a stable clot?
Creating a protein mesh
What term describes the process of platelets sticking to the exposed collagen at the site of injury in hemostasis?
Adhesion
What would be the consequence of impaired hemostasis in the body?
Increased risk of uncontrolled bleeding
What is the function of the elastic fibers in the blood vessel?
To give the blood vessel the ability to expand and contract
What is released by endothelial cells during primary hemostasis?
Von Willebrand factor, tissue factor, prostacyclin, nitric oxide
Why does platelet activation stop during primary hemostasis?
Platelet aggregation; stops due to clot retraction
What is the role of thrombin in hemostasis?
It activates the coagulation cascade
What is the main function of prostaglandin and nitric oxide in the platelet process?
Inhibit platelets
What is the role of ADP and thromboxane A2 in platelet activation?
Activate platelets
What happens when platelets express GPIIB/IIIA?
They are considered fully activated
Which blood protein acts like handcuffs linking platelets together during hemostasis?
Fibrinogen
What is the final step in the process of platelet activation?
Aggregation
What is the purpose of GPIIB/IIIA receptors on platelets?
To link platelets together
What limits the positive feedback loop of platelet activation to the injury site?
Prostaglandin and nitric oxide
What is the primary function of platelet plug formation in hemostasis?
To prevent further blood loss from a damaged vessel
What is the primary function of antithrombin III in the coagulation process?
Inhibits thrombin activity
What is the main function of plasmin in the fibrinolytic system?
Degrades fibrin clots
Which component of the blood vessel is responsible for the structural integrity and protection of the vessel?
Collagen in the connective tissue
What happens when the smooth muscle cells contract in a blood vessel?
The lumen size decreases
Which vitamin is essential for the synthesis of clotting factors II, VII, IX, and X?
Vitamin K
What is the function of collagen in the blood vessel structure?
To provide structural support and protection
What is the primary function of Von Willebrand factor in the process of haemostasis?
Promotes platelet adhesion to damaged endothelium
Why is it important for blood vessels to have the ability to expand and contract?
To regulate blood flow and pressure
Which of the following is a natural anticoagulant produced by the body?
Antithrombin III
What is the role of smooth muscle cells in blood vessels during injury?
To trigger a reflexive contraction near the injury site
What is the role of thromboxane A2 in platelet aggregation?
Stimulates platelet aggregation
What is the primary function of endothelial cells in blood vessels?
To secrete nitric oxide and prostaglandins
Which enzyme is responsible for converting fibrinogen to fibrin in the coagulation cascade?
Thrombin
What is the purpose of a vascular spasm in response to an arterial injury?
To decrease blood flow to the injured area
How do nitric oxide and prostaglandins affect smooth muscles in blood vessels?
Cause relaxation of nearby smooth muscles
Which of the following is NOT a component of the coagulation cascade?
Thromboxane A2
What is the role of platelets in hemostasis?
To aggregate and form a plug at the site of injury
What is the purpose of the protein mesh made of fibrin in hemostasis?
To reinforce the platelet plug
What is the role of collagen fibers in hemostasis?
To reinforce the platelet plug and protect the vessel
What is the function of smooth muscle cells in blood vessels?
To anchor the vessel to surrounding tissues
Why is secondary hemostasis necessary?
To further reinforce the platelet plug
What is the primary function of fibrinogen in hemostasis?
To form a protein mesh by being cleaved into fibrin
Study Notes
Hemostasis
- Promotes fibrinolysis through platelet activation
- Primary platelet adhesion receptors promote platelet adhesion
- Fibrin forms a protein mesh to create a stable clot
- Platelet adhesion to collagen is a key step in hemostasis
- Endothelial cells secrete Von Willebrand factor, tissue factor, prostacyclin, and nitric oxide
Coagulation Cascade
- Fibrinogen is converted to fibrin by thrombin
- Factor VIII, X, and Protein C are components of the coagulation cascade
- Thromboxane A2 stimulates platelet aggregation and vasoconstriction
Blood Vessels
- Elastic fibers allow blood vessels to expand and contract
- Smooth muscle cells trigger reflexive contraction near the injury site
- Endothelial cells detect injuries and trigger vascular spasms
- Collagen provides structural support and protection to blood vessels
Platelet Activation
- ADP and thromboxane A2 activate platelets
- Prostaglandin and nitric oxide inhibit platelet activation
- GPIIB/IIIA receptors on platelets link platelets together
- Platelet plug formation prevents further blood loss from a damaged vessel
Fibrinolysis
- Plasmin degrades fibrin clots
- Antithrombin III inhibits thrombin activity
- Fibrinolysis is essential for clot dissolution
Vitamin and Hormone Functions
- Vitamin K is essential for the synthesis of clotting factors II, VII, IX, and X
- Prostacyclin and nitric oxide cause relaxation of smooth muscles
- Thromboxane A2 stimulates platelet aggregation and vasoconstriction
Test your knowledge on the process of hemostasis and blood clotting, including platelet adhesion, fibrinolysis, and coagulation cascade.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
