41 Questions
Where does the formation of blood cells commence during fetal development?
In the wall of the yolk sac
What is the major site of blood cell formation in a normal adult?
Bone marrow
What do pluripotent haemal stem cells give rise to?
Stem cells that can form major groups of blood cells other than lymphocytes
From which region do the definitive hematopoietic stem cells originate?
Aorta-gonad-mesonephros (AGM) region
What is the population of stem cells that can generate all types of blood cells?
Self-replicating stem cells
What is the name of the stem cell that can develop into either lymphocytic stem cells or pluripotent haemal stem cells?
Colony-forming unit stem cells (CFU-S)
When does the liver lose its blood-forming function?
After the 7th month of development
What is the name of the cell that gives rise to erythrocytes?
Proerythroblast
What is the site where stem cells from the liver colonize in the 7th month of gestation?
Bone marrow
What do Multipotent hematopoietic stem cells give rise to?
Myeloid stem cells and Lymphoid stem cells
What are the cellular components of the blood that arise from stem cells?
All types of blood cells
What is the name of the cell that gives rise to platelets?
Megakaryoblast
What is the name of the stem cell that gives rise to B lymphocytes and T lymphocytes?
Lymphoid stem cells
Which of the following is NOT a site of haemopoiesis during fetal development?
Brain
What is the name of the cell that gives rise to monocytes and macrophages?
Monoblast
What is the name of the cell that gives rise to neutrophils, eosinophils and basophils?
Myeloblast
What is the location of the A, B, O blood antigens?
On the extracellular domain of glycophorins
What type of protein is the Rh antigen?
Multi-pass integral membrane protein
What is the function of the iron-containing heme group in hemoglobin?
To transport oxygen
What is the shape of platelets?
Biconvex disks
What percentage of hemoglobin in healthy adults is composed of HbA2?
2%
What is the characteristic shape of red blood cells in patients with sickle cell anemia?
Sickle
What is the origin of platelets?
From the cytoplasm of a megakaryocyte in the bone marrow
What is the main difference between HbA and HbS?
The amino acid sequence of their subunits
What is the function of platelets in the body?
To initiate blood clots
What type of WBC is responsible for fighting against parasitic infections?
Eosinophil
What is the percentage of HbF in newborns?
80%
When do normal adult levels of hemoglobin are reached in infants?
At 8 months of age
What is the name of the WBC with a multi-lobed nucleus?
Neutrophil
What is the term for an increased number of neutrophils in circulation?
Neutrophilia
What is the term for a decreased number of neutrophils in circulation?
Neutropenia
What is the life span of platelets?
About 10 days
What is the average lifespan of an erythrocyte in blood?
120 days
What is the shape of an erythrocyte?
Biconcave disk
What is the function of erythrocytes?
Transport of oxygen and carbon dioxide
What is the diameter of an erythrocyte?
8 µm
What is the composition of the erythrocyte cell membrane?
40% lipid, 50% protein, 10% carbohydrate
What is the role of spectrin in erythrocytes?
Maintaining cell shape
What is the name of the disease caused by defective spectrin?
Hereditary spherocytosis
What is the function of the cytoskeleton in erythrocytes?
Maintaining cell shape
What is the appearance of erythrocytes under a light microscope?
Pink circle with a light center
Learn about the formation of blood cells during fetal development, including the sites and timelines of hemopoiesis in the yolk sac, liver, spleen, and bone marrow. Understand the process of blood cell formation from the second month to birth. Test your knowledge of hemopoiesis in this quiz!
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
