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Where does the formation of blood cells commence during fetal development?

In the wall of the yolk sac (correct)

In the bone marrow

In the spleen

In the liver

What is the major site of blood cell formation in a normal adult?

Spleen

Liver

Yolk sac

Bone marrow (correct)

What do pluripotent haemal stem cells give rise to?

Only lymphocytes

Only megakaryocytes

Only erythrocytes

Stem cells that can form major groups of blood cells other than lymphocytes (correct)

From which region do the definitive hematopoietic stem cells originate?

Aorta-gonad-mesonephros (AGM) region Signup and view all the answers

What is the population of stem cells that can generate all types of blood cells?

Self-replicating stem cells Signup and view all the answers

What is the name of the stem cell that can develop into either lymphocytic stem cells or pluripotent haemal stem cells?

Colony-forming unit stem cells (CFU-S) Signup and view all the answers

When does the liver lose its blood-forming function?

After the 7th month of development Signup and view all the answers

What is the name of the cell that gives rise to erythrocytes?

Proerythroblast Signup and view all the answers

What is the site where stem cells from the liver colonize in the 7th month of gestation?

Bone marrow Signup and view all the answers

What do Multipotent hematopoietic stem cells give rise to?

Myeloid stem cells and Lymphoid stem cells Signup and view all the answers

What are the cellular components of the blood that arise from stem cells?

All types of blood cells Signup and view all the answers

What is the name of the cell that gives rise to platelets?

Megakaryoblast Signup and view all the answers

What is the name of the stem cell that gives rise to B lymphocytes and T lymphocytes?

Lymphoid stem cells Signup and view all the answers

Which of the following is NOT a site of haemopoiesis during fetal development?

Brain Signup and view all the answers

What is the name of the cell that gives rise to monocytes and macrophages?

Monoblast Signup and view all the answers

What is the name of the cell that gives rise to neutrophils, eosinophils and basophils?

Myeloblast Signup and view all the answers

What is the location of the A, B, O blood antigens?

On the extracellular domain of glycophorins Signup and view all the answers

What type of protein is the Rh antigen?

Multi-pass integral membrane protein Signup and view all the answers

What is the function of the iron-containing heme group in hemoglobin?

To transport oxygen Signup and view all the answers

What is the shape of platelets?

Biconvex disks Signup and view all the answers

What percentage of hemoglobin in healthy adults is composed of HbA2?

2% Signup and view all the answers

What is the characteristic shape of red blood cells in patients with sickle cell anemia?

Sickle Signup and view all the answers

What is the origin of platelets?

From the cytoplasm of a megakaryocyte in the bone marrow Signup and view all the answers

What is the main difference between HbA and HbS?

The amino acid sequence of their subunits Signup and view all the answers

What is the function of platelets in the body?

To initiate blood clots Signup and view all the answers

What type of WBC is responsible for fighting against parasitic infections?

Eosinophil Signup and view all the answers

What is the percentage of HbF in newborns?

80% Signup and view all the answers

When do normal adult levels of hemoglobin are reached in infants?

At 8 months of age Signup and view all the answers

What is the name of the WBC with a multi-lobed nucleus?

Neutrophil Signup and view all the answers

What is the term for an increased number of neutrophils in circulation?

Neutrophilia Signup and view all the answers

What is the term for a decreased number of neutrophils in circulation?

Neutropenia Signup and view all the answers

What is the life span of platelets?

About 10 days Signup and view all the answers

What is the average lifespan of an erythrocyte in blood?

120 days Signup and view all the answers

What is the shape of an erythrocyte?

Biconcave disk Signup and view all the answers

What is the function of erythrocytes?

Transport of oxygen and carbon dioxide Signup and view all the answers

What is the diameter of an erythrocyte?

8 µm Signup and view all the answers

What is the composition of the erythrocyte cell membrane?

40% lipid, 50% protein, 10% carbohydrate Signup and view all the answers

What is the role of spectrin in erythrocytes?

Maintaining cell shape Signup and view all the answers

What is the name of the disease caused by defective spectrin?

Hereditary spherocytosis Signup and view all the answers

What is the function of the cytoskeleton in erythrocytes?