Hemophilia A and B Quiz

<p>Joint deformity and disability (D)</p> Signup and view all the answers

<p>Bleeding time (BT) (B)</p> Signup and view all the answers

<p>Because it can be difficult to control the bleeding. (D)</p> Signup and view all the answers

<p>It is caused by a deficiency of factor IX (E)</p> Signup and view all the answers

<p>A rare complication of Hemophilia characterized by a progressive swelling of muscle and/or bone due to repeated bleeding. (C)</p> Signup and view all the answers

<p>It can occur due to spontaneous mutation. (C)</p> Signup and view all the answers

<p>Von Willebrand Disease Type 3 (C)</p> Signup and view all the answers

<p>Promoting platelet adhesion to damaged endothelium and platelet aggregation (A)</p> Signup and view all the answers

<p>vWF is unable to protect FVIII from premature degradation. (C)</p> Signup and view all the answers

<p>Type 2B (D)</p> Signup and view all the answers

<p>Spontaneous mutation (A)</p> Signup and view all the answers

<p>VWF:Ag (A)</p> Signup and view all the answers

<p>Elevated platelet count (C)</p> Signup and view all the answers

<p>Functional abnormality of fibrinogen biosynthesis (B)</p> Signup and view all the answers

<p>All of the above (D)</p> Signup and view all the answers

<p>Decreased synthesis of coagulation factors (D)</p> Signup and view all the answers

<p>Increased serum levels of antithrombin (D)</p> Signup and view all the answers

<p>All of the above (D)</p> Signup and view all the answers

<p>Obstruction of small vessels by fibrin strands (C)</p> Signup and view all the answers

<p>Promoting the synthesis of vitamin K-dependent coagulation factors in the liver (C)</p> Signup and view all the answers

<p>FFP replenishes depleted coagulation factors and platelets (C)</p> Signup and view all the answers

<p>The patient has a deficiency in Factor VIII or IX (C)</p> Signup and view all the answers

<p>It can be associated with autoimmune disorders (B)</p> Signup and view all the answers

<p>Umbilical cord blood analysis for factor IX levels (A)</p> Signup and view all the answers

<p>This can lead to a misdiagnosis of Hemophilia B in newborns. (A)</p> Signup and view all the answers

<p>Factor IX replacement therapy (D)</p> Signup and view all the answers

<p>Hemophilia A (C)</p> Signup and view all the answers

<p>It explains why Hemophilia A and Hemophilia B are often inherited together. (C)</p> Signup and view all the answers

<p>It can significantly reduce the frequency of bleeds and improve quality of life. (C)</p> Signup and view all the answers

<p>Hemorrhagic disease of the newborn (A)</p> Signup and view all the answers

<p>The lack of von Willebrand factor prevents platelets from clumping together at the site of injury, leading to prolonged bleeding. (D)</p> Signup and view all the answers

<p>Hemophilia A usually presents with deep tissue bleeding, while Von Willebrand's disease commonly causes mucosal bleeding. (C)</p> Signup and view all the answers

<p>Prolonged PT and aPTT, normal platelet count, and normal fibrinogen levels. (A)</p> Signup and view all the answers

<p>Warfarin inhibits the synthesis of certain clotting factors, including II, VII, IX, and X, thereby reducing the clotting ability of the blood. (D)</p> Signup and view all the answers

<p>Ristocetin causes the von Willebrand factor to bind to platelets, initiating the formation of platelet clumps. (B)</p> Signup and view all the answers

<p>Von Willebrand's disease (D)</p> Signup and view all the answers

<p>HDN is characterized by an inability to absorb Vitamin K due to immature liver cells in newborns. (C)</p> Signup and view all the answers

A hereditary bleeding disorder caused by deficiency of Factor VIII.

A hereditary bleeding disorder caused by deficiency of Factor IX.

An inherited bleeding disorder characterized by lack of von Willebrand factor (vWf).

The inheritance pattern for Hemophilia; primarily affects males.

Unpredictable bleeding without apparent cause, common in hemophilia.

Joint bleeding common in hemophilia, leading to pain and swelling.

Dependent on the blood level of Factor VIII; lower levels lead to worse bleeding.

Include blood count, PT, PTT, and bleeding time to detect bleeding disorders.

Prolonged partial thromboplastin time indicating intrinsic pathway disruption in hemophilia A and B.

A test done after prolonged PTT to check for factor deficiency by mixing patient's plasma with normal plasma.

Diagnosis of hemophilia is confirmed if factor VIII activity is less than 40% of normal.

Detection of FVIII levels in fetal blood during 16-20 weeks gestation using ultrasound-guided needle aspiration.

Synthetic vasopressin that stimulates release of FVIII and vWF from endothelial cells, boosting plasma levels.

Infusion of FIX, which has a longer half-life than FVIII and requires less frequent infusions.

Non-genetic form of hemophilia A caused by autoantibodies against factor VIII, often associated with autoimmune disorders.

Prolonged aPTT and reduced FIX clotting assay; normal bleeding time and PT.

A disorder caused by reduced levels or abnormal function of von Willebrand factor (vWF).

Also known as hemophilia B, characterized by low levels of factor IX, tested through umbilical cord blood.

Three types: Type 1 (mild), Type 2 (abnormal vWF), Type 3 (severe deficiency).

Use of DNA probes to detect mutations in carriers of hemophilia genes.

Promotes platelet adhesion to damaged endothelium and protects factor VIII from degradation.

Prolonged bleeding time, low FVIII, prolonged aPTT, low vWF, defective platelet aggregation.

An immunoassay measuring the concentration of vWF protein in plasma.

An antibiotic that causes platelet clumping by binding von Willebrand factor (VWF) to platelets.

A bleeding disorder characterized by deficiency or dysfunction of VWF, affecting blood clotting.

VWD typically causes mucosal bleeding, such as nosebleeds and gum bleeds.

A condition caused by inadequate intake or absorption of vitamin K, leading to bleeding issues.

A condition in newborns due to vitamin K deficiency, causing severe bleeding.

Prolonged PT and aPTT with normal platelet count and fibrinogen levels.

Use of oral vitamin K to prevent bleeding in liver dysfunction.

Biliary obstruction impairs vitamin K absorption and coagulation factor synthesis.

Decreased thrombopoietin production from liver leads to low platelet counts.

Widespread clotting and consumption of clotting factors & platelets due to disorders.

Procoagulant materials released due to conditions like liver disease and infections.

Characteristics include low platelet count and increased D-dimers.

Damaged liver cells release thromboplastin leading to DIC complications.

Use of fresh frozen plasma or RBC transfusion to treat DIC.