Podcast
Questions and Answers
What is the main cause of acute hemolytic transfusion reactions?
What is the main cause of acute hemolytic transfusion reactions?
- Recipient antibody attacking transfused donor cells (correct)
- Complement attacking transfused cells
- Extravascular RBC destruction
- Intravascular RBC destruction
Why are hemolytic transfusion reactions involving extravascular RBC destruction generally less serious?
Why are hemolytic transfusion reactions involving extravascular RBC destruction generally less serious?
- Complement is not involved in these reactions
- Destruction primarily occurs in the reticuloendothelial system (correct)
- These reactions occur due to ABO incompatibility
- Recipient antibodies immediately hemolyze transfused RBCs
What is the incidence of an acute hemolytic transfusion reaction resulting from ABO incompatibility in 2011?
What is the incidence of an acute hemolytic transfusion reaction resulting from ABO incompatibility in 2011?
- 1:1200 to 1:190,000. (correct)
- 1:200,000
- 1:45,000
- 1:19,000
What is crucial to prevent during hemolytic transfusion reactions?
What is crucial to prevent during hemolytic transfusion reactions?
How do fatal reactions occurring in blood recipients or donors need to be reported according to FDA requirements?
How do fatal reactions occurring in blood recipients or donors need to be reported according to FDA requirements?
What was the primary cause of deaths from acute hemolytic reactions between 1976 and 1985?
What was the primary cause of deaths from acute hemolytic reactions between 1976 and 1985?
What is the classic presenting sign of a hemolytic transfusion reaction under general anesthesia?
What is the classic presenting sign of a hemolytic transfusion reaction under general anesthesia?
At what level of plasma hemoglobin (Hb) concentration does hemoglobinuria occur?
At what level of plasma hemoglobin (Hb) concentration does hemoglobinuria occur?
What protein binds free hemoglobin in the plasma?
What protein binds free hemoglobin in the plasma?
What laboratory test can confirm the presence of a hemolytic transfusion reaction?
What laboratory test can confirm the presence of a hemolytic transfusion reaction?
What may be the only clue of a hemolytic transfusion reaction under general anesthesia?
What may be the only clue of a hemolytic transfusion reaction under general anesthesia?
Which substance is released due to complement activation during a hemolytic transfusion reaction?
Which substance is released due to complement activation during a hemolytic transfusion reaction?
what is the most common sign and Symptoms of
Hemolytic Transfusion Reactions
what is the most common sign and Symptoms of Hemolytic Transfusion Reactions
What is the likely cause of acute renal failure from intravascular hemolysis?
What is the likely cause of acute renal failure from intravascular hemolysis?
What is one approach to therapy for intravascular hemolysis to prevent acute renal failure?
What is one approach to therapy for intravascular hemolysis to prevent acute renal failure?
Why is alkalization of urine recommended in the treatment for intravascular hemolysis?
Why is alkalization of urine recommended in the treatment for intravascular hemolysis?
Why does Disseminated Intravascular Coagulation (DIC) commonly occur with hemolytic transfusion reactions?
Why does Disseminated Intravascular Coagulation (DIC) commonly occur with hemolytic transfusion reactions?
What is the recommended approach if initial mannitol administration is ineffective in treating intravascular hemolysis?
What is the recommended approach if initial mannitol administration is ineffective in treating intravascular hemolysis?
What is a possible consequence of intravascular hemolysis on the renal system?
What is a possible consequence of intravascular hemolysis on the renal system?
What laboratory values should be obtained as soon as a hemolytic transfusion reaction is recognized?
What laboratory values should be obtained as soon as a hemolytic transfusion reaction is recognized?
What may cause hypotension during a hemolytic transfusion reaction?
What may cause hypotension during a hemolytic transfusion reaction?
What is the purpose of obtaining baseline platelet count, PT, and PTT values during a hemolytic transfusion reaction?
What is the purpose of obtaining baseline platelet count, PT, and PTT values during a hemolytic transfusion reaction?
In a hemolytic transfusion reaction, why is it important to have baseline laboratory values for comparison?
In a hemolytic transfusion reaction, why is it important to have baseline laboratory values for comparison?
What is the main reason for the delayed hemolytic transfusion reactions in recipients sensitized to RBC antigens?
What is the main reason for the delayed hemolytic transfusion reactions in recipients sensitized to RBC antigens?
Which system commonly involves antibodies in delayed hemolytic transfusion reactions?
Which system commonly involves antibodies in delayed hemolytic transfusion reactions?
What is the typical manifestation of delayed hemolytic transfusion reactions?
What is the typical manifestation of delayed hemolytic transfusion reactions?
Why are delayed hemolytic transfusion reactions more common in females with a known disposition for alloimmunization?
Why are delayed hemolytic transfusion reactions more common in females with a known disposition for alloimmunization?
How do delayed hemolytic transfusion reactions differ from immediate reactions regarding antibody concentration?
How do delayed hemolytic transfusion reactions differ from immediate reactions regarding antibody concentration?
What is the primary cause of RBC destruction in delayed hemolytic transfusion reactions?
What is the primary cause of RBC destruction in delayed hemolytic transfusion reactions?
What should the surgical team consider in a patient who experiences an unexplained decrease in Hb 2 to 21 days after a transfusion?
What should the surgical team consider in a patient who experiences an unexplained decrease in Hb 2 to 21 days after a transfusion?
Why are delayed hemolytic transfusion reactions harder to prevent compared to immediate reactions?
Why are delayed hemolytic transfusion reactions harder to prevent compared to immediate reactions?
What is a critical differential diagnosis that the surgical team should include for patients with a decrease in Hb after a transfusion?
What is a critical differential diagnosis that the surgical team should include for patients with a decrease in Hb after a transfusion?
Why might a decrease in Hb following a transfusion in a postoperative patient lead to a return to the operative room?
Why might a decrease in Hb following a transfusion in a postoperative patient lead to a return to the operative room?
What is a significant challenge in preventing delayed hemolytic transfusion reactions according to the text?
What is a significant challenge in preventing delayed hemolytic transfusion reactions according to the text?
What is the most common cause of transfusion-related mortality reported to the FDA from 2012 to 2016?
What is the most common cause of transfusion-related mortality reported to the FDA from 2012 to 2016?
What symptom of TRALI usually appears within 6 hours after a blood transfusion?
What symptom of TRALI usually appears within 6 hours after a blood transfusion?
Why is TRALI considered to occur in the absence of excessive intravascular volume and cardiac failure?
Why is TRALI considered to occur in the absence of excessive intravascular volume and cardiac failure?
What is the definitive therapy recommended for treating TRALI during a blood transfusion?
What is the definitive therapy recommended for treating TRALI during a blood transfusion?
Which component of blood is particularly implicated as an inciting factor for TRALI?
Which component of blood is particularly implicated as an inciting factor for TRALI?
the incidence of TRALI is
the incidence of TRALI is
despite TRALI remains the leading cause of transfusion-related death. most patients recover within
despite TRALI remains the leading cause of transfusion-related death. most patients recover within
Identified risk factors include all the following except?
Identified risk factors include all the following except?
what is the most common risk factor for TRALI?
what is the most common risk factor for TRALI?
What clinical finding can help differentiate between TRALI and TACO?
What clinical finding can help differentiate between TRALI and TACO?
What is a possible reason for the declining incidence rate of TACO according to the text?
What is a possible reason for the declining incidence rate of TACO according to the text?
Besides volume transfused, what other factor is mentioned as a risk factor for TACO?
Besides volume transfused, what other factor is mentioned as a risk factor for TACO?
How have leukoreduction techniques been suggested to impact the incidence rate of TACO?
How have leukoreduction techniques been suggested to impact the incidence rate of TACO?
What supportive measure is recommended in both TRALI and TACO cases according to the text?
What supportive measure is recommended in both TRALI and TACO cases according to the text?
What treatment is recommended to relieve the symptoms of an allergic reaction during a blood transfusion?
What treatment is recommended to relieve the symptoms of an allergic reaction during a blood transfusion?
Which symptom characterizes the more severe allergic reaction involving anaphylaxis during a blood transfusion?
Which symptom characterizes the more severe allergic reaction involving anaphylaxis during a blood transfusion?
What type of blood should be given to patients who have experienced anaphylactic reactions due to IgA deficiency?
What type of blood should be given to patients who have experienced anaphylactic reactions due to IgA deficiency?
What is the cause of anaphylactic reactions in patients during a blood transfusion?
What is the cause of anaphylactic reactions in patients during a blood transfusion?
How do anaphylactic reactions differ from other allergic reactions during a blood transfusion?
How do anaphylactic reactions differ from other allergic reactions during a blood transfusion?
What is the primary cause of febrile nonhemolytic reactions to blood transfusions?
What is the primary cause of febrile nonhemolytic reactions to blood transfusions?
How can a hemolytic reaction be differentiated from a febrile reaction?
How can a hemolytic reaction be differentiated from a febrile reaction?
What is the role of leukoreduced blood in reducing adverse reactions to transfusions?
What is the role of leukoreduced blood in reducing adverse reactions to transfusions?
What symptom is not typically associated with a febrile nonhemolytic reaction to a blood transfusion?
What symptom is not typically associated with a febrile nonhemolytic reaction to a blood transfusion?
What type of allergic reaction to a blood transfusion is not mediated by IgE?
What type of allergic reaction to a blood transfusion is not mediated by IgE?
Which test can definitively confirm the presence of a hemolytic transfusion reaction?
Which test can definitively confirm the presence of a hemolytic transfusion reaction?
which type of allergic reaction to a blood transfusion is the most common ?
which type of allergic reaction to a blood transfusion is the most common ?
what is the main cause for Most allergic transfusion reactions
what is the main cause for Most allergic transfusion reactions
what is The most common symptom in allergic transfusion reactions ?
what is The most common symptom in allergic transfusion reactions ?
patient arriving to operation room, planned for liver resection, surgeon informing you that this patient has a high risk for bleeding intraoperative due to surgical factors, and also informing you that he had allergic reaction for blood transfusion few years ago. what s your next step?
patient arriving to operation room, planned for liver resection, surgeon informing you that this patient has a high risk for bleeding intraoperative due to surgical factors, and also informing you that he had allergic reaction for blood transfusion few years ago. what s your next step?
What is the primary mechanism by which transfusion-associated graft-versus-host disease (GVHD) is initiated?
What is the primary mechanism by which transfusion-associated graft-versus-host disease (GVHD) is initiated?
who is considered at risk for GVHD?
who is considered at risk for GVHD?
How can transfusion-associated GVHD be prevented?
How can transfusion-associated GVHD be prevented?
Which symptom is commonly associated with transfusion-associated GVHD?
Which symptom is commonly associated with transfusion-associated GVHD?
In what situation might transfusion-associated GVHD still occur despite leukocyte filtering?
In what situation might transfusion-associated GVHD still occur despite leukocyte filtering?
why patients receiving directed donations from first or second-degree relatives are at risk for Transfusion-associated graft-versus-host disease (GVHD) ?
why patients receiving directed donations from first or second-degree relatives are at risk for Transfusion-associated graft-versus-host disease (GVHD) ?
What is the main complication associated with iron overload resulting from chronic transfusion therapy?
What is the main complication associated with iron overload resulting from chronic transfusion therapy?
What is the term for the condition in which recipient alloantibodies attack donor platelet antigens post-transfusion?
What is the term for the condition in which recipient alloantibodies attack donor platelet antigens post-transfusion?
Which complication may arise due to HLA alloimmunization resulting in antibodies directed against HLA class I antigens?
Which complication may arise due to HLA alloimmunization resulting in antibodies directed against HLA class I antigens?
What is the outcome for patients with microchimerism where donor lymphocytes persist in the patient?
What is the outcome for patients with microchimerism where donor lymphocytes persist in the patient?
Which type of transfusion reaction involves activation of the coagulation pathway leading to bradykinin production and allergic reactions?
Which type of transfusion reaction involves activation of the coagulation pathway leading to bradykinin production and allergic reactions?
What is the risk associated with HPA alloimmunization leading to platelet refractoriness from antibodies against platelet antigens?
What is the risk associated with HPA alloimmunization leading to platelet refractoriness from antibodies against platelet antigens?
what is the percentage of recipients who are chronically transfused develop RBC alloantibodies ?
what is the percentage of recipients who are chronically transfused develop RBC alloantibodies ?
How can universal leukoreduction help reduce the risk of platelet transfusion refractoriness?
How can universal leukoreduction help reduce the risk of platelet transfusion refractoriness?
What is one of the benefits that universal leukoreduction might provide according to the text?
What is one of the benefits that universal leukoreduction might provide according to the text?
In the debate on universal leukoreduction, which approach has been used to justify its implementation?
In the debate on universal leukoreduction, which approach has been used to justify its implementation?
How can leukoreduction potentially reduce the transmission of variant Creutzfeldt-Jakob disease?
How can leukoreduction potentially reduce the transmission of variant Creutzfeldt-Jakob disease?
Which type of blood products need to be irradiated to prevent transfusion-associated GVHD?
Which type of blood products need to be irradiated to prevent transfusion-associated GVHD?
Who is particularly recommended to receive irradiated blood products to prevent GVHD?
Who is particularly recommended to receive irradiated blood products to prevent GVHD?
For which patients undergoing extracorporeal membrane oxygenation is irradiation of blood products recommended?
For which patients undergoing extracorporeal membrane oxygenation is irradiation of blood products recommended?
What is a common indication for irradiation of blood products other than in infants and critically ill children?
What is a common indication for irradiation of blood products other than in infants and critically ill children?
Which recipients are NOT required to have their blood products irradiated to prevent GVHD?
Which recipients are NOT required to have their blood products irradiated to prevent GVHD?
When is irradiation of blood products not necessary according to the text?
When is irradiation of blood products not necessary according to the text?
