Podcast
Questions and Answers
What is the primary mechanism by which IgM antibodies cause cold-reactive immune hemolytic anemia?
What is the primary mechanism by which IgM antibodies cause cold-reactive immune hemolytic anemia?
- They bind to cells at the cooler temperature of the extremities and dissociate from the cell surface
- They bind to cells at warmer temperatures and fix complement
- They bind to cells at the warmer temperature of the central circulation and fix complement
- They bind to cells at the cooler temperature of the extremities and fix complement (correct)
What is the typical age range of individuals affected by primary cold agglutinin disease?
What is the typical age range of individuals affected by primary cold agglutinin disease?
- 40-60 years
- 20-40 years
- 70 years and above (correct)
- 60-70 years
What is the primary cause of secondary cold agglutinin disease?
What is the primary cause of secondary cold agglutinin disease?
- Genetic mutations
- Underlying disorders such as cancer and autoimmune diseases
- Infections such as Mycoplasma pneumonia and Epstein-Barr virus (correct)
- Unknown causes
What is the typical duration of secondary cold agglutinin disease?
What is the typical duration of secondary cold agglutinin disease?
What is the typical effect of cold temperatures on the anemia associated with primary cold agglutinin disease?
What is the typical effect of cold temperatures on the anemia associated with primary cold agglutinin disease?
What is the primary site of agglutination in primary cold agglutinin disease?
What is the primary site of agglutination in primary cold agglutinin disease?
What is the typical gender distribution of primary cold agglutinin disease?
What is the typical gender distribution of primary cold agglutinin disease?
What is the primary effect of the complement components on the cell surface?
What is the primary effect of the complement components on the cell surface?
What is the primary difference between primary and secondary cold agglutinin disease?
What is the primary difference between primary and secondary cold agglutinin disease?
What is the typical course of primary cold agglutinin disease?
What is the typical course of primary cold agglutinin disease?
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