Hemoproteins
55 Questions
1 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the central metal ion in heme?

  • Magnesium
  • Iron Fe2+ (correct)
  • Zinc
  • Copper

    • How many pyrrole rings are there in a heme molecule?

  • 2
  • 3
  • 4 (correct)
  • 5

    • Which of the following is NOT a hemoprotein?

  • Hemoglobin
  • Myoglobin
  • Insulin (correct)
  • Catalase

    • How many heme groups are present in hemoglobin?

    <p>4</p> Signup and view all the answers

    Which helix binds to the proximal histidine (F8) in hemoglobin?

    <p>Helix F</p> Signup and view all the answers

    What type of bond stabilizes the heme group in the globin pocket?

    <p>Hydrophobic interactions</p> Signup and view all the answers

    In hemoglobin, the sixth coordination site of iron binds to:

    <p>An oxygen molecule</p> Signup and view all the answers

    What is one key role of the apoprotein part of hemoglobin?

    <p>To make heme soluble in water</p> Signup and view all the answers

    What is the Bohr effect in hemoglobin

    <p>The effect of pH on oxygen affinity</p> Signup and view all the answers

    why does hemoglobin have a higher affinity for CO than O2?

    <p>The bond angle and structure of CO allowed to fit better in the binding pocket</p> Signup and view all the answers

    which amino acid in the polypeptide chain produces steric hindrance that produces CO binding affinity?

    <p>Histidine E7</p> Signup and view all the answers

    What is the main function of myoglobin?

    <p>Store oxygen in muscles</p> Signup and view all the answers

    how many oxygen molecules can one hemoglobin molecule carry

    <p>4</p> Signup and view all the answers

    which has a higher affinity for oxygen, myoglobin or hemoglobin

    <p>Myoglobin</p> Signup and view all the answers

    What percentage of adult hemoglobin is HbA?

    <p>98</p> Signup and view all the answers

    Where is hemoglobin primarily located?

    <p>In Red blood cells</p> Signup and view all the answers

    What is the structure of adult hemoglobin?

    <p>Two alpha chains and two beta chains</p> Signup and view all the answers

    and hemoglobin oxygen binding is facilitated by which structural property?

    <p>Cooperative binding among the four subunits</p> Signup and view all the answers

    What type of protein structure does HbA1 have?

    <p>Tetrameric</p> Signup and view all the answers

    How many alpha chains are present in HbA1?

    <p>2</p> Signup and view all the answers

    The two dims and hemoglobin are held together by

    <p>Ionic bones and hydrogen bond</p> Signup and view all the answers

    which of the following describes the quaternary structure of hemoglobin?

    <p>Arrangement of two alpha chains and two butter chains as two dimers</p> Signup and view all the answers

    which of the following describes the quaternary structure of hemoglobin?

    <p>Arrangement of two alpha chains and two butter chains as two dimers</p> Signup and view all the answers

    what happens to the hemoglobin molecule when it binds to oxygen?

    <p>it shifts to the R form</p> Signup and view all the answers

    Which factor does not affect the oxygen binding ability of hemoglobin

    <p>Nitrogen</p> Signup and view all the answers

    Which of the following stabilizes the T form of hemoglobin

    <p>Protonation</p> Signup and view all the answers

    what is the role of 2,3- BPG in hemoglobin function?

    <p>decreases hemoglobin’s affinity for oxygen</p> Signup and view all the answers

    Hemoglobin exhibits cooperative binding, this means:

    <p>The binding of one oxygen molecule increases the affinity for the next oxygen molecule</p> Signup and view all the answers

    Hemoglobin exhibits cooperative binding, this means:

    <p>The binding of one oxygen molecule increases the affinity for the next oxygen molecule</p> Signup and view all the answers

    Which bonds are broken during the T to R transition in hemoglobin?

    <p>Salt bridges</p> Signup and view all the answers

    What molecule forms when liberated hydrogen ions bind with bicarbonate in the blood

    <p>Carbonic acid</p> Signup and view all the answers

    The Bohr effect facilitates the release of oxygen in tissues by

    <p>Decreasing pH</p> Signup and view all the answers

    The Bohr effect facilitates the release of oxygen in tissues by

    <p>Decreasing pH</p> Signup and view all the answers

    Carbaminohemoglobin is formed when CO2 binds to

    <p>The N terminal amino group of globin chains</p> Signup and view all the answers

    Carbon monoxide bonds through hemoglobin at the same site as

    <p>Oxygen</p> Signup and view all the answers

    which form of hemoglobin is toxic and prevents oxygen release in tissues

    <p>Carboxyhemoglobin</p> Signup and view all the answers

    Which hemoglobin type is primarily present during the first three months of pregnancy?

    <p>Hb Gower</p> Signup and view all the answers

    Glycated hemoglobin (HbA1c) reflects blood glucose levels over the past:

    <p>60 to 90 days</p> Signup and view all the answers

    A HbA1c level greater than 6.5% typically indicates

    <p>Diabetes</p> Signup and view all the answers

    Where is myoglobin primarily found?

    <p>Muscles</p> Signup and view all the answers

    The alpha globin gene family is located on chromosome

    <p>16</p> Signup and view all the answers

    Which gene is expressed during the first three months of pregnancy

    <p>Zeta gene</p> Signup and view all the answers

    Hb Gower is formed by the combination of which chains?

    <p>Zeta and epsilon</p> Signup and view all the answers

    Sickle cell anemia is caused by a mutation in the gene coding for

    <p>Beta globin</p> Signup and view all the answers

    In sickle cell anemia, which amino acid is replaced in the beta globin chain?

    <p>Glutamate replaced by Valine</p> Signup and view all the answers

    Individuals with sickle cell treat have

    <p>Both HbA and HbS</p> Signup and view all the answers

    What amino acid is replaced by lysine in hemoglobin C (HbC) disease?

    <p>Glutamate</p> Signup and view all the answers

    What is a key symptom of hemoglobin C (HbC) disease?

    <p>RBC crystallization leading to mild anemia</p> Signup and view all the answers

    What happens in methemoglobinemia?

    <p>Fe2+ is converted to Fe3+</p> Signup and view all the answers

    What type of thalassemia results in the formation of Hb Bart (y4) and Hb H (beta 4)?

    <p>Homozygous alpha thalassemia</p> Signup and view all the answers

    Which gene defect leads to alpha thalassemia major

    <p>Defect in three alpha genes</p> Signup and view all the answers

    Why does a patient with beta thalassemia major appear normal at birth?

    <p>Presence of HbF</p> Signup and view all the answers

    What is HbA2 composed of?

    <p>a2 delta 2</p> Signup and view all the answers

    What is the common characteristic of thalassemia disorders?

    <p>Mutation or deletion in the globin genes</p> Signup and view all the answers

    Which abnormal hemoglobin results from the replacement of histidine by tyrosine?

    <p>HbM</p> Signup and view all the answers

    More Like This

    Use Quizgecko on...
    Browser
    Open
    Browser
    Browser