11 Questions
What is the goal of allogenic transplant in malignant disorders?
Curative effect of chemotherapy and/or radiation in the preparative regimen and immunologic graft versus leukemia (GVL) effect.
What is the primary goal of allogenic transplant in non-malignant disorders?
Replacing a defective hematopoietic system.
What is the first choice for a donor in allogenic transplant?
Matched sibling.
What is the chance of finding a fully matched sibling in Saudi Arabia?
60%.
What is the indication for allogenic transplant in AML patients?
AML in CR1 with intermediate or poor risk cytogenetics.
What is the indication for allogenic transplant in ALL patients?
High Risk ALL CR1 (e.g. Ph+ ALL).
What is the indication for allogenic transplant in lymphoma patients?
Lymphoma relapsing after autologous transplant.
What is the indication for allogenic transplant in inherited immune disorders?
Severe combined immunodeficiency, chronic granulomatous diseases, hemophagocytic lymphohistiocytosis, and others.
What is the indication for allogenic transplant in inherited hemoglobinopathies?
Sickle cell disease and beta-thalassemia.
What is the indication for allogenic transplant in marrow failure states?
Severe aplastic anemia, Fanconi anemia, and others.
What is the role of HLA matching in allogenic transplant?
Selecting the best donor.
This quiz covers the complications that may arise during the neutropenic phase of hematopoietic stem cell transplantation, including the effects of cryopreservatives like DMSO and the importance of supportive care and antimicrobial therapy. Learn about the risks and challenges of this critical phase.
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