Hematopoietic Stem Cell Transplantation Complications
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Questions and Answers

What is the goal of allogenic transplant in malignant disorders?

Curative effect of chemotherapy and/or radiation in the preparative regimen and immunologic graft versus leukemia (GVL) effect.

What is the primary goal of allogenic transplant in non-malignant disorders?

Replacing a defective hematopoietic system.

What is the first choice for a donor in allogenic transplant?

Matched sibling.

What is the chance of finding a fully matched sibling in Saudi Arabia?

<p>60%.</p> Signup and view all the answers

What is the indication for allogenic transplant in AML patients?

<p>AML in CR1 with intermediate or poor risk cytogenetics.</p> Signup and view all the answers

What is the indication for allogenic transplant in ALL patients?

<p>High Risk ALL CR1 (e.g. Ph+ ALL).</p> Signup and view all the answers

What is the indication for allogenic transplant in lymphoma patients?

<p>Lymphoma relapsing after autologous transplant.</p> Signup and view all the answers

What is the indication for allogenic transplant in inherited immune disorders?

<p>Severe combined immunodeficiency, chronic granulomatous diseases, hemophagocytic lymphohistiocytosis, and others.</p> Signup and view all the answers

What is the indication for allogenic transplant in inherited hemoglobinopathies?

<p>Sickle cell disease and beta-thalassemia.</p> Signup and view all the answers

What is the indication for allogenic transplant in marrow failure states?

<p>Severe aplastic anemia, Fanconi anemia, and others.</p> Signup and view all the answers

What is the role of HLA matching in allogenic transplant?

<p>Selecting the best donor.</p> Signup and view all the answers

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