Hematopoiesis and Blood Cell Lifespans Overview
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Questions and Answers

What is the basic structure of bone marrow?

  • Dense irregular connective tissue with a network of lymphatic vessels
  • Stratified squamous epithelium with specialized crypts
  • Columnar epithelium with goblet cells
  • Loose connective tissue with scattered islands of hematopoietic cells (correct)
  • How does a single type of multipotential stem cell give rise to two lineages (myeloid cells and lymphocytes), and then each of those two lineages gives rise to all the mature blood cells?

  • By symmetric cell division followed by fusion of daughter cells to create diverse lineages
  • Through a process of endoreduplication resulting in distinct genetic profiles in the daughter cells
  • By random assortment of chromosomes during mitosis creating diverse genetic combinations
  • By asymmetric cell division leading to differential gene expression in the daughter cells (correct)
  • Where does the production of new blood cells occur after birth?

  • Bone marrow (correct)
  • Liver
  • Spleen
  • Lymphatic tissues
  • What gives rise to all the lymphocytes?

    <p>Bone marrow</p> Signup and view all the answers

    Which type of bone marrow is responsible for the production of blood and blood-forming cells?

    <p>Red bone marrow</p> Signup and view all the answers

    What is the approximate life span of a reticulocyte in the bloodstream?

    <p>6-8 hours</p> Signup and view all the answers

    Which growth factor is synthesized and secreted by the kidney in response to decreased blood oxygen concentration?

    <p>Erythropoietin (EPO)</p> Signup and view all the answers

    What does the term 'shift to the left' in the context of granulocytes refer to?

    <p>Increase in immature neutrophils in the blood</p> Signup and view all the answers

    What is the progenitor for both monocytes and granulocytes?

    <p>GFU-GM</p> Signup and view all the answers

    Where do newly formed monocytes primarily enter after leaving the circulation?

    <p>Connective tissue spaces of the body</p> Signup and view all the answers

    Which cell type transform into macrophages within a day or two of entering the connective tissue spaces?

    <p>Monocytes</p> Signup and view all the answers

    Where do some lymphoid stem cells migrate to differentiate into T lymphocytes?

    <p>Thymus</p> Signup and view all the answers

    What is the characteristic feature of thrombopoiesis involving the nucleus?

    <p>It becomes highly polyploid</p> Signup and view all the answers

    What is the source of platelets in adults?

    <p>Red bone marrow</p> Signup and view all the answers

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