Hematopoiesis and Blood Cell Lifespans Overview

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What is the basic structure of bone marrow?

Loose connective tissue with scattered islands of hematopoietic cells

How does a single type of multipotential stem cell give rise to two lineages (myeloid cells and lymphocytes), and then each of those two lineages gives rise to all the mature blood cells?

By asymmetric cell division leading to differential gene expression in the daughter cells

Where does the production of new blood cells occur after birth?

Bone marrow

What gives rise to all the lymphocytes?

<p>Bone marrow</p> Signup and view all the answers

Which type of bone marrow is responsible for the production of blood and blood-forming cells?

<p>Red bone marrow</p> Signup and view all the answers

What is the approximate life span of a reticulocyte in the bloodstream?

<p>6-8 hours</p> Signup and view all the answers

Which growth factor is synthesized and secreted by the kidney in response to decreased blood oxygen concentration?

<p>Erythropoietin (EPO)</p> Signup and view all the answers

What does the term 'shift to the left' in the context of granulocytes refer to?

<p>Increase in immature neutrophils in the blood</p> Signup and view all the answers

What is the progenitor for both monocytes and granulocytes?

<p>GFU-GM</p> Signup and view all the answers

Where do newly formed monocytes primarily enter after leaving the circulation?

<p>Connective tissue spaces of the body</p> Signup and view all the answers

Which cell type transform into macrophages within a day or two of entering the connective tissue spaces?

<p>Monocytes</p> Signup and view all the answers

Where do some lymphoid stem cells migrate to differentiate into T lymphocytes?

<p>Thymus</p> Signup and view all the answers

What is the characteristic feature of thrombopoiesis involving the nucleus?

<p>It becomes highly polyploid</p> Signup and view all the answers

What is the source of platelets in adults?

<p>Red bone marrow</p> Signup and view all the answers

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