Hematology: Thalassemia Lecture 5
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Questions and Answers

What is thalassemia and what is its effect on red blood cells?

Thalassemia is an inherited blood disorder characterized by an abnormal form of hemoglobin, resulting in excessive destruction of red blood cells, leading to anemia.

What are the two major types of thalassemia and what causes them?

The two major types of thalassemia are alpha thalassemia, caused by a defect in the rate of synthesis of alpha chains, and beta thalassemia, caused by a defect in the rate of synthesis of beta chains.

Where are the genes for alpha and beta subunits of hemoglobin located?

The genes for alpha subunits are located on chromosome 16, and the genes for beta subunits are located on chromosome 11.

What is the difference between alpha thalassemia and beta thalassemia in terms of their genetic causes?

<p>Alpha thalassemia is usually caused by gene deletion, while beta thalassemia is usually caused by a mutation.</p> Signup and view all the answers

What is the composition of adult hemoglobin?

<p>Adult hemoglobin is composed of two alpha chains and two beta chains.</p> Signup and view all the answers

What is a potential benefit associated with thalassemia?

<p>Thalassemia may contribute to protection against malaria.</p> Signup and view all the answers

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