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Questions and Answers
What are some physiological abnormalities observed in β thalassemia major patients?
Iron overload, oxidative stress, and aggregated β-globin proteins
What membrane-bound proteins showed significant increase in RBCs from β thalassemia major patients?
COX-2 and CD38
Which protein participates in reactive oxygen species (ROS) production due to iron overload in β thalassemia major?
Acetylcholinesterase (AChE)
What is the name for the cell death in RBCs induced by overproduction of amyloid β (Aβ) peptides?
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What is the hallmark of β thalassemia major, induced by AChE upregulation?
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What process does iron overload induce in RBCs from β thalassemia major patients?
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