Hematology Study Notes

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Questions and Answers

What is the functional unit of erythropoiesis?

  • Thymus
  • Erythrone (correct)
  • Myeloid tissue
  • Lymph node

In adults, where does erythropoiesis primarily occur?

  • Liver and spleen
  • Thymus
  • Lymph nodes
  • Bone marrow (correct)

What percentage does hemoglobin A₁ typically constitute in adult red blood cells?

  • 1%
  • 50%
  • 97% (correct)
  • 3%

What is the primary function of NADH in erythrocyte metabolism?

<p>Prevention of heme oxidation (A)</p> Signup and view all the answers

What is the main purpose of the hexose monophosphate pathway in erythrocytes?

<p>Glutathione reduction (D)</p> Signup and view all the answers

Approximately how long is the typical lifespan of a red blood cell?

<p>120 days (A)</p> Signup and view all the answers

What is the role of the spleen in relation to erythrocytes?

<p>Removal of defective erythrocytes (B)</p> Signup and view all the answers

What process occurs during the catabolism of hemoglobin?

<p>Bilirubin production (D)</p> Signup and view all the answers

What serum level defines anemia, according to general practice?

<p>Decreased erythrocytic mass (D)</p> Signup and view all the answers

Elevation of 2,3-DPG in anemia results in what physiological change?

<p>Decreased oxygen affinity (A)</p> Signup and view all the answers

What is the typical MCV range for normocytic anemia?

<p>80-100 fL (A)</p> Signup and view all the answers

When classifying anemias by morphology, what condition is suggested by spherocytes?

<p>Hereditary spherocytosis (B)</p> Signup and view all the answers

In anemia evaluations, under what condition do reticulocytes fall into the 'regenerative' category?

<p>Hemolysis (A)</p> Signup and view all the answers

How is the reticulocyte production index (IC) calculated?

<p>% reticulociti x (Hematocrit norma/ Hematocrit paziente)/2 (B)</p> Signup and view all the answers

In anemia, what is the most common cause to see a 'rouleaux' formation on a peripheral blood smear?

<p>Multiple myeloma (C)</p> Signup and view all the answers

Which of the following is commonly associated with dacrocytes (teardrop cells) on a blood smear?

<p>Myelofibrosis (A)</p> Signup and view all the answers

What do Howell-Jolly bodies in erythrocytes indicate?

<p>Splenic dysfunction (B)</p> Signup and view all the answers

Which of the following is most indicative of microcytic anemia?

<p>Reduced MCV (D)</p> Signup and view all the answers

Which lab marker is most specific for sideropenia?

<p>Reduced ferretin (B)</p> Signup and view all the answers

What defines severe aplastic anemia?

<p>All of the above (D)</p> Signup and view all the answers

What primary lab test helps differentiate anemia of chronic disease from iron-deficiency anemia?

<p>Fe levels in bone marrow. (A)</p> Signup and view all the answers

What is the role of hepcidin in anemia of chronic disease?

<p>Inhibits iron release from macrophages (B)</p> Signup and view all the answers

What is a typical morphological cell change with myelophthisic anemia?

<p>Teardrop cells (B)</p> Signup and view all the answers

What blood examination combo suggests myelophthisis?

<p>leukoerythroblastic reaction (immature cells) and presence (C)</p> Signup and view all the answers

What is the basic problem with megaloblastic anemias like B12's?

<p>Defective DNA (C)</p> Signup and view all the answers

The most likely first presentation symptom of aplasia?

<p>Pancytpenia (B)</p> Signup and view all the answers

What is often seen in relation to aplastic anemia's medullar analysis result?

<p>Hypocellular (B)</p> Signup and view all the answers

What is generally the treatment plan for anemia?

<p>BM (D)</p> Signup and view all the answers

Aplastic Anemia typically progresses with what?

<p>Clonal Evolution (D)</p> Signup and view all the answers

Fanconi Anemia normally displays at what age typically?

<p>5, 6 (D)</p> Signup and view all the answers

Pure red cell hypoplasia is also known as what?

<p>Blackfan (A)</p> Signup and view all the answers

PNH a mutation in which genes?

<p>Pig-A (B)</p> Signup and view all the answers

What part of cell gets attacked in PNH?

<p>Linfocites T (C)</p> Signup and view all the answers

What will bone marrow in anemia show after diagnosis?

<p>Ipo cellular (A)</p> Signup and view all the answers

What is the most common Aplastic cause?

<p>Idiopathic (D)</p> Signup and view all the answers

The key diagnostic feature, what is that?

<p>Dx BM 1 cellularity (A)</p> Signup and view all the answers

Lack of a gene is cause to PNH because what?

<p>CD55 (C)</p> Signup and view all the answers

Myelopthisis is due more often to?

<p>Metasizes (C)</p> Signup and view all the answers

Mye cell is?

<p>Dacryocyte (D)</p> Signup and view all the answers

Sider Blasts are due to?

<p>Ca (C)</p> Signup and view all the answers

If test positive low ferret WHAT else to see??

<p>Emptiness (B)</p> Signup and view all the answers

Acanthocytes indicates

<p>SickelCell (D)</p> Signup and view all the answers

MacroOvalocytes is?

<p>Mega (C)</p> Signup and view all the answers

In anemia classification, what condition do 'anisocytes' describe?

<p>Variations in cell size (D)</p> Signup and view all the answers

What abnormality is suggested by the presence of 'pila de monedas' in a blood smear?

<p>Protein abnormalities (D)</p> Signup and view all the answers

What morphological alteration is indicated primarily with the presence of prevalent schistocytes?

<p>Hemolytic process (A)</p> Signup and view all the answers

In evaluating a patient with suspected Diamond-Blackfan anemia, what would be the expected finding in the peripheral blood smear?

<p>Decreased reticulocyte count (A)</p> Signup and view all the answers

Which of the following cytogenetic abnormalities is most closely associated with resistance to therapy and progression to myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) in the context of aplastic anemia?

<p>ASXL1 and DNMT3 (D)</p> Signup and view all the answers

Of the following etiologies related to acquired selective aplasia, which typically has a 30% occurence rate?

<p>Thymoma (D)</p> Signup and view all the answers

A patient presents with pancytopenia without splenomegaly. The underlying cause is determined to with Aplastic Anemia, which one confirms the diagnosis?

<p>bone marrow analysis (A)</p> Signup and view all the answers

What combination in observed analysis suggests Myelopthisis?

<p>DACrocytes with cell count increase (A)</p> Signup and view all the answers

Which cellular morphology is the leading one that would define Myeolpthisis?

<p>dacrocites (A)</p> Signup and view all the answers

What underlying mechanism causes an increase in the EPO during anemia due to chronic disease/syndrome?

<p>EPO response inhibition (D)</p> Signup and view all the answers

In which way is iron normally provided to the erythrocyte development?

<p>Marrow and Transferrin (B)</p> Signup and view all the answers

What is not a feature or consequence in sideriopenia?

<p>Esistono prove evidenti di deficit di ferro. (B)</p> Signup and view all the answers

Indicate the following signs which points of anemia in relation to a deficit in vitamina B12?

<p>All of above (D)</p> Signup and view all the answers

Besides the typical general anemia parameters and values related to a B12 deficiency, which ones comes from the exam's result?

<p>Un aumento dell'eliminazione urinaria (C)</p> Signup and view all the answers

What alteration should be added to the following 3: Sindrome anemica, infezioni emorragiche?

<p>Diminuzione midollare (A)</p> Signup and view all the answers

If there isn't iron for eryth, what would test show?

<p>Elevted protophyrin (A)</p> Signup and view all the answers

Which test should you never not repeat because the result changes?

<p>Bone marrow extraction (D)</p> Signup and view all the answers

Which situation can alter hemoglobin's ability?

<p>aumenta del 2-3 DPG (A)</p> Signup and view all the answers

What’s the best to recognize Mielofibrosis?

<p>Pancyt and spleno (A)</p> Signup and view all the answers

Regarding Anemia of Fanconi, what is the most likely occurence?

<p>anemia, i bambini presentano varie malformazioni (A)</p> Signup and view all the answers

Which of the following best explain why to look at mieloblastici before any other factor?

<p>displasia (B)</p> Signup and view all the answers

In the MDS analysis results, which comes first

<p>morph dysplasia (A)</p> Signup and view all the answers

In which case do a high level of LDH is normally seen?

<p>as the emolisis (D)</p> Signup and view all the answers

Which result of test should remember that must to be the opposite when Siderpenia?

<p>Ferritine (C)</p> Signup and view all the answers

What is the primary cause of sideropenia from the non bleeding causes?

<p>food and drink (C)</p> Signup and view all the answers

Which morph of Cell is the best at time?

<p>Normal (A)</p> Signup and view all the answers

If an anemic patient, already low volume WHAT to see?

<p>False increase (B)</p> Signup and view all the answers

As a general statement, How reticoliti relate to bone?

<p>medular problem (A)</p> Signup and view all the answers

What is the composition of hemoglobin A₁ in adult red blood cells?

<p>α2-β2 (D)</p> Signup and view all the answers

What process generates NADH in erythrocytes?

<p>Embden-Meyerhof pathway (C)</p> Signup and view all the answers

What characterizes the erythrocytic cellularity observed in the bone marrow during aplastic anemia?

<p>Hypocellularity (B)</p> Signup and view all the answers

In evaluating anemia, which finding suggests iron deficiency?

<p>Decreased serum iron (D)</p> Signup and view all the answers

What is the primary role of EPO (erythropoietin) in treating anemia?

<p>Stimulate red blood cell production in the bone marrow (A)</p> Signup and view all the answers

A patient has rouleaux formation on a peripheral blood smear. Which condition is probably generating these?

<p>Hyperproteinemia (D)</p> Signup and view all the answers

The presence of Howell-Jolly bodies in red blood cells signifies that probably there isn't of what activity?

<p>Non-functional or absent spleen (B)</p> Signup and view all the answers

Which outcome results from elevated 2,3-DPG levels in anemia?

<p>Increased oxygen delivery (A)</p> Signup and view all the answers

What does the presence suggest of 'pila de monedas' (Rouleaux formation) in a blood smear?

<p>Multiple myeloma (B)</p> Signup and view all the answers

What key observation would lead to suspicion specifically for myelopthisic anemia?

<p>Leukoerythroblastosis and dacrocytes (B)</p> Signup and view all the answers

What etiological detail correlates with a higher rate typically to acquired selective aplasia?

<p>Idiopathic events (B)</p> Signup and view all the answers

Elevated serum ferritin and its correlation with anemia

<p>Favors anemia of chronic disease, may hides iron deficiency (C)</p> Signup and view all the answers

A patient with anemia also has angular stomatitis, glossitis, and koilonychia. Which one should relate them?

<p>Sideropenic anemia (A)</p> Signup and view all the answers

Following first steps at anemia study to approach likely hemolytic etiologies, which indicates intravascular lysis?

<p>Hemoglubinuria (A)</p> Signup and view all the answers

Which statement is true about using hydroxyurea?

<p>It useful by augmenting y chains synthesis (D)</p> Signup and view all the answers

Which finding, upon diagnostic review, would most probably confirm the initial anemic assessment for Fanconi’s congenital form diagnosis?

<p>DB test at chromosome level (D)</p> Signup and view all the answers

In evaluating a patient with anemia, a high RDW (red cell distribution width) is noted. What does it probably indicate?

<p>There is increased variation in erythrocyte size (A)</p> Signup and view all the answers

Hemoglobin catabolism produces what?

<p>Amino acids, iron, and bilirubin (B)</p> Signup and view all the answers

You test hemoglobin A2 but the test comes lowWHAT else to see??

<p>Beta thalassemia minor (A)</p> Signup and view all the answers

A peripheral film from a patient, already low in VCM when is normal test to found

<p>Retics lows (D)</p> Signup and view all the answers

Flashcards

Anemia

A condition characterized by reduced red blood cell mass.

Mean Corpuscular Volume (MCV)

The average volume of red blood cells.

Microcytic Anemia

Small red blood cells, often seen in iron deficiency anemia.

Normocytic Anemia

Normal-sized red blood cells, seen in anemia of chronic disease.

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Macrocytic Anemia

Large red blood cells, common in vitamin B12 or folate deficiency.

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Reticulocytes

Immature red blood cells, indicator of bone marrow activity.

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Rouleaux Formation

Red blood cell arrangement like stacked coins, seen in multiple myeloma.

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Poikilocytosis

Irregular red cell shape, seen in myelodysplastic syndrome.

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Dacrocytes

Tear-drop shaped red cells, commonly seen in myelofibrosis.

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Myelodysplastic Syndromes (MDS)

A group of bone marrow disorders where stem cells don't mature.

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Pancytopenia

Decreased production of all blood cell types, often due to bone marrow failure.

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Myelophthisic Anemia

Bone marrow infiltration by non-hematopoietic cells, leading to anemia.

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Sideropenic Anemia

Deficiency of iron due to various causes.

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Anemia of Chronic Disease

Anemia due to chronic inflammatory or malignant conditions impairing iron utilization.

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Fanconi anemia

Rare inherited blood disorder that causes a decrease in all blood cell types.

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Dyskeratosis congenital

A congenital disease that presents abnormal skin and nails.

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Hodgkin's Lymphoma

A type of blood cancer (lymphoma) in which cancer cells spread through the lymphatic system.

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Coombs test

A test used to detect antibodies that act against your red blood cells.

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Hepatobiliary disorders

Most common, is associated with abnormal fat metabolism, causes the red blood cells to have abnormal shapes.

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Study Notes

  • The following are study notes on hematology.

Ematologia

  • Study notes on hematology covering key concepts:
    • Anemias and hematologic malignancies
    • Diagnostic approaches
    • Relevant clinical information

Topic Subtitle

  • Megaloblastic Anemia (B12/Folic acid) is marked by ^^^MCV (>110) an elevated Mean Corpuscular Volume
  • Myelodysplasia is also noted
  • Alcohol intake should be noted in patient history
  • Iron Potentially bound

Sindromi Linfoproliferative Croniche (SLPC)

  • Philadelphia chromosome presence is indicative of Leukemia Mieloide Cronica (LMC)
  • Includes Philadelphia + % T
  • Indicates Trombocitemia Essenziale (TE) and Jak2 mutations

Topic Subtitle

  • Presence of Rouleaux formation
  • SMD indicated by:
    • Refrattory Cytopenia
    • Multilinies Aroma refation
    • Increased AReb -to (5-9 14) and SMD is 5q

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