Podcast
Questions and Answers
What is the functional unit of erythropoiesis?
What is the functional unit of erythropoiesis?
- Thymus
- Erythrone (correct)
- Myeloid tissue
- Lymph node
In adults, where does erythropoiesis primarily occur?
In adults, where does erythropoiesis primarily occur?
- Liver and spleen
- Thymus
- Lymph nodes
- Bone marrow (correct)
What percentage does hemoglobin A₁ typically constitute in adult red blood cells?
What percentage does hemoglobin A₁ typically constitute in adult red blood cells?
- 1%
- 50%
- 97% (correct)
- 3%
What is the primary function of NADH in erythrocyte metabolism?
What is the primary function of NADH in erythrocyte metabolism?
What is the main purpose of the hexose monophosphate pathway in erythrocytes?
What is the main purpose of the hexose monophosphate pathway in erythrocytes?
Approximately how long is the typical lifespan of a red blood cell?
Approximately how long is the typical lifespan of a red blood cell?
What is the role of the spleen in relation to erythrocytes?
What is the role of the spleen in relation to erythrocytes?
What process occurs during the catabolism of hemoglobin?
What process occurs during the catabolism of hemoglobin?
What serum level defines anemia, according to general practice?
What serum level defines anemia, according to general practice?
Elevation of 2,3-DPG in anemia results in what physiological change?
Elevation of 2,3-DPG in anemia results in what physiological change?
What is the typical MCV range for normocytic anemia?
What is the typical MCV range for normocytic anemia?
When classifying anemias by morphology, what condition is suggested by spherocytes?
When classifying anemias by morphology, what condition is suggested by spherocytes?
In anemia evaluations, under what condition do reticulocytes fall into the 'regenerative' category?
In anemia evaluations, under what condition do reticulocytes fall into the 'regenerative' category?
How is the reticulocyte production index (IC) calculated?
How is the reticulocyte production index (IC) calculated?
In anemia, what is the most common cause to see a 'rouleaux' formation on a peripheral blood smear?
In anemia, what is the most common cause to see a 'rouleaux' formation on a peripheral blood smear?
Which of the following is commonly associated with dacrocytes (teardrop cells) on a blood smear?
Which of the following is commonly associated with dacrocytes (teardrop cells) on a blood smear?
What do Howell-Jolly bodies in erythrocytes indicate?
What do Howell-Jolly bodies in erythrocytes indicate?
Which of the following is most indicative of microcytic anemia?
Which of the following is most indicative of microcytic anemia?
Which lab marker is most specific for sideropenia?
Which lab marker is most specific for sideropenia?
What defines severe aplastic anemia?
What defines severe aplastic anemia?
What primary lab test helps differentiate anemia of chronic disease from iron-deficiency anemia?
What primary lab test helps differentiate anemia of chronic disease from iron-deficiency anemia?
What is the role of hepcidin in anemia of chronic disease?
What is the role of hepcidin in anemia of chronic disease?
What is a typical morphological cell change with myelophthisic anemia?
What is a typical morphological cell change with myelophthisic anemia?
What blood examination combo suggests myelophthisis?
What blood examination combo suggests myelophthisis?
What is the basic problem with megaloblastic anemias like B12's?
What is the basic problem with megaloblastic anemias like B12's?
The most likely first presentation symptom of aplasia?
The most likely first presentation symptom of aplasia?
What is often seen in relation to aplastic anemia's medullar analysis result?
What is often seen in relation to aplastic anemia's medullar analysis result?
What is generally the treatment plan for anemia?
What is generally the treatment plan for anemia?
Aplastic Anemia typically progresses with what?
Aplastic Anemia typically progresses with what?
Fanconi Anemia normally displays at what age typically?
Fanconi Anemia normally displays at what age typically?
Pure red cell hypoplasia is also known as what?
Pure red cell hypoplasia is also known as what?
PNH a mutation in which genes?
PNH a mutation in which genes?
What part of cell gets attacked in PNH?
What part of cell gets attacked in PNH?
What will bone marrow in anemia show after diagnosis?
What will bone marrow in anemia show after diagnosis?
What is the most common Aplastic cause?
What is the most common Aplastic cause?
The key diagnostic feature, what is that?
The key diagnostic feature, what is that?
Lack of a gene is cause to PNH because what?
Lack of a gene is cause to PNH because what?
Myelopthisis is due more often to?
Myelopthisis is due more often to?
Mye cell is?
Mye cell is?
Sider Blasts are due to?
Sider Blasts are due to?
If test positive low ferret WHAT else to see??
If test positive low ferret WHAT else to see??
Acanthocytes indicates
Acanthocytes indicates
MacroOvalocytes is?
MacroOvalocytes is?
In anemia classification, what condition do 'anisocytes' describe?
In anemia classification, what condition do 'anisocytes' describe?
What abnormality is suggested by the presence of 'pila de monedas' in a blood smear?
What abnormality is suggested by the presence of 'pila de monedas' in a blood smear?
What morphological alteration is indicated primarily with the presence of prevalent schistocytes?
What morphological alteration is indicated primarily with the presence of prevalent schistocytes?
In evaluating a patient with suspected Diamond-Blackfan anemia, what would be the expected finding in the peripheral blood smear?
In evaluating a patient with suspected Diamond-Blackfan anemia, what would be the expected finding in the peripheral blood smear?
Which of the following cytogenetic abnormalities is most closely associated with resistance to therapy and progression to myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) in the context of aplastic anemia?
Which of the following cytogenetic abnormalities is most closely associated with resistance to therapy and progression to myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) in the context of aplastic anemia?
Of the following etiologies related to acquired selective aplasia, which typically has a 30% occurence rate?
Of the following etiologies related to acquired selective aplasia, which typically has a 30% occurence rate?
A patient presents with pancytopenia without splenomegaly. The underlying cause is determined to with Aplastic Anemia, which one confirms the diagnosis?
A patient presents with pancytopenia without splenomegaly. The underlying cause is determined to with Aplastic Anemia, which one confirms the diagnosis?
What combination in observed analysis suggests Myelopthisis?
What combination in observed analysis suggests Myelopthisis?
Which cellular morphology is the leading one that would define Myeolpthisis?
Which cellular morphology is the leading one that would define Myeolpthisis?
What underlying mechanism causes an increase in the EPO during anemia due to chronic disease/syndrome?
What underlying mechanism causes an increase in the EPO during anemia due to chronic disease/syndrome?
In which way is iron normally provided to the erythrocyte development?
In which way is iron normally provided to the erythrocyte development?
What is not a feature or consequence in sideriopenia?
What is not a feature or consequence in sideriopenia?
Indicate the following signs which points of anemia in relation to a deficit in vitamina B12?
Indicate the following signs which points of anemia in relation to a deficit in vitamina B12?
Besides the typical general anemia parameters and values related to a B12 deficiency, which ones comes from the exam's result?
Besides the typical general anemia parameters and values related to a B12 deficiency, which ones comes from the exam's result?
What alteration should be added to the following 3: Sindrome anemica, infezioni emorragiche?
What alteration should be added to the following 3: Sindrome anemica, infezioni emorragiche?
If there isn't iron for eryth, what would test show?
If there isn't iron for eryth, what would test show?
Which test should you never not repeat because the result changes?
Which test should you never not repeat because the result changes?
Which situation can alter hemoglobin's ability?
Which situation can alter hemoglobin's ability?
What’s the best to recognize Mielofibrosis?
What’s the best to recognize Mielofibrosis?
Regarding Anemia of Fanconi, what is the most likely occurence?
Regarding Anemia of Fanconi, what is the most likely occurence?
Which of the following best explain why to look at mieloblastici before any other factor?
Which of the following best explain why to look at mieloblastici before any other factor?
In the MDS analysis results, which comes first
In the MDS analysis results, which comes first
In which case do a high level of LDH is normally seen?
In which case do a high level of LDH is normally seen?
Which result of test should remember that must to be the opposite when Siderpenia?
Which result of test should remember that must to be the opposite when Siderpenia?
What is the primary cause of sideropenia from the non bleeding causes?
What is the primary cause of sideropenia from the non bleeding causes?
Which morph of Cell is the best at time?
Which morph of Cell is the best at time?
If an anemic patient, already low volume WHAT to see?
If an anemic patient, already low volume WHAT to see?
As a general statement, How reticoliti relate to bone?
As a general statement, How reticoliti relate to bone?
What is the composition of hemoglobin A₁ in adult red blood cells?
What is the composition of hemoglobin A₁ in adult red blood cells?
What process generates NADH in erythrocytes?
What process generates NADH in erythrocytes?
What characterizes the erythrocytic cellularity observed in the bone marrow during aplastic anemia?
What characterizes the erythrocytic cellularity observed in the bone marrow during aplastic anemia?
In evaluating anemia, which finding suggests iron deficiency?
In evaluating anemia, which finding suggests iron deficiency?
What is the primary role of EPO (erythropoietin) in treating anemia?
What is the primary role of EPO (erythropoietin) in treating anemia?
A patient has rouleaux formation on a peripheral blood smear. Which condition is probably generating these?
A patient has rouleaux formation on a peripheral blood smear. Which condition is probably generating these?
The presence of Howell-Jolly bodies in red blood cells signifies that probably there isn't of what activity?
The presence of Howell-Jolly bodies in red blood cells signifies that probably there isn't of what activity?
Which outcome results from elevated 2,3-DPG levels in anemia?
Which outcome results from elevated 2,3-DPG levels in anemia?
What does the presence suggest of 'pila de monedas' (Rouleaux formation) in a blood smear?
What does the presence suggest of 'pila de monedas' (Rouleaux formation) in a blood smear?
What key observation would lead to suspicion specifically for myelopthisic anemia?
What key observation would lead to suspicion specifically for myelopthisic anemia?
What etiological detail correlates with a higher rate typically to acquired selective aplasia?
What etiological detail correlates with a higher rate typically to acquired selective aplasia?
Elevated serum ferritin and its correlation with anemia
Elevated serum ferritin and its correlation with anemia
A patient with anemia also has angular stomatitis, glossitis, and koilonychia. Which one should relate them?
A patient with anemia also has angular stomatitis, glossitis, and koilonychia. Which one should relate them?
Following first steps at anemia study to approach likely hemolytic etiologies, which indicates intravascular lysis?
Following first steps at anemia study to approach likely hemolytic etiologies, which indicates intravascular lysis?
Which statement is true about using hydroxyurea?
Which statement is true about using hydroxyurea?
Which finding, upon diagnostic review, would most probably confirm the initial anemic assessment for Fanconi’s congenital form diagnosis?
Which finding, upon diagnostic review, would most probably confirm the initial anemic assessment for Fanconi’s congenital form diagnosis?
In evaluating a patient with anemia, a high RDW (red cell distribution width) is noted. What does it probably indicate?
In evaluating a patient with anemia, a high RDW (red cell distribution width) is noted. What does it probably indicate?
Hemoglobin catabolism produces what?
Hemoglobin catabolism produces what?
You test hemoglobin A2 but the test comes lowWHAT else to see??
You test hemoglobin A2 but the test comes lowWHAT else to see??
A peripheral film from a patient, already low in VCM when is normal test to found
A peripheral film from a patient, already low in VCM when is normal test to found
Flashcards
Anemia
Anemia
A condition characterized by reduced red blood cell mass.
Mean Corpuscular Volume (MCV)
Mean Corpuscular Volume (MCV)
The average volume of red blood cells.
Microcytic Anemia
Microcytic Anemia
Small red blood cells, often seen in iron deficiency anemia.
Normocytic Anemia
Normocytic Anemia
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Macrocytic Anemia
Macrocytic Anemia
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Reticulocytes
Reticulocytes
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Rouleaux Formation
Rouleaux Formation
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Poikilocytosis
Poikilocytosis
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Dacrocytes
Dacrocytes
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Myelodysplastic Syndromes (MDS)
Myelodysplastic Syndromes (MDS)
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Pancytopenia
Pancytopenia
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Myelophthisic Anemia
Myelophthisic Anemia
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Sideropenic Anemia
Sideropenic Anemia
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Anemia of Chronic Disease
Anemia of Chronic Disease
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Fanconi anemia
Fanconi anemia
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Dyskeratosis congenital
Dyskeratosis congenital
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Hodgkin's Lymphoma
Hodgkin's Lymphoma
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Coombs test
Coombs test
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Hepatobiliary disorders
Hepatobiliary disorders
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Study Notes
- The following are study notes on hematology.
Ematologia
- Study notes on hematology covering key concepts:
- Anemias and hematologic malignancies
- Diagnostic approaches
- Relevant clinical information
Topic Subtitle
- Megaloblastic Anemia (B12/Folic acid) is marked by ^^^MCV (>110) an elevated Mean Corpuscular Volume
- Myelodysplasia is also noted
- Alcohol intake should be noted in patient history
- Iron Potentially bound
Sindromi Linfoproliferative Croniche (SLPC)
- Philadelphia chromosome presence is indicative of Leukemia Mieloide Cronica (LMC)
- Includes Philadelphia + % T
- Indicates Trombocitemia Essenziale (TE) and Jak2 mutations
Topic Subtitle
- Presence of Rouleaux formation
- SMD indicated by:
- Refrattory Cytopenia
- Multilinies Aroma refation
- Increased AReb -to (5-9 14) and SMD is 5q
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