Podcast
Questions and Answers
What is the most common finding in red blood cells in this condition?
What is the most common finding in red blood cells in this condition?
Which of the following is a common finding in neutrophils in this condition?
Which of the following is a common finding in neutrophils in this condition?
What is the final diagnosis based on?
What is the final diagnosis based on?
What is hemoglobinopathy related to?
What is hemoglobinopathy related to?
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What is the normal percentage of HbA in adult hemoglobin?
What is the normal percentage of HbA in adult hemoglobin?
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Which of the following is a common finding in platelets in this condition?
Which of the following is a common finding in platelets in this condition?
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Study Notes
Megaloblastic Anemia
- Characterized by extremely low Hb and red cell count
- HCT may reflect the actual decrease in erythrocytes due to enlarged size of the red cells
- Marked increase in MCV, potentially up to 130fl
- MCH varies, but usually increased in 90% of cases
- RDW is increased
- TLC usually shows leucopenia, particularly neutropenia
- Platelet count is usually decreased, with some large platelets
- Peripheral blood smear features:
- Marked anisocytosis with macrocytic and normochromic cells
- Marked poikilocytosis with oval macrocytes, tear drop cells, and microcytes
- Basophilic stippling, Howell Jolly bodies, and nucleated red blood cells
- Neutrophils with hypersegmentation (6-10 lobes) and enlarged size
Hemoglobinopathies
- Represent inherited or genetic defects related to hemoglobin
- Defects can result in:
- Quantitative defects (e.g., thalassemia): deficiency in normal adult hemoglobin synthesis
- Qualitative defects (e.g., sickle cell anemia): abnormal structure of the hemoglobin molecule
- Normal adult hemoglobin composition:
- HbA (α2β2): 95%-98%
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Description
Test your knowledge on red blood cell characteristics including Hb and red cell count, HCT, MCV, MCH, RDW, TLC, and platelet count. Learn to identify abnormalities in peripheral blood smears such as anisocytosis and macrocytic normochromic cells.
