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Questions and Answers
What is the most common finding in red blood cells in this condition?
What is the most common finding in red blood cells in this condition?
- Anisocytosis
- Normocytosis
- Microcytosis
- Macrocytosis (correct)
Which of the following is a common finding in neutrophils in this condition?
Which of the following is a common finding in neutrophils in this condition?
- Hypersegmentation (correct)
- Hyposegmentation
- Normal segmentation
- Absence of segmentation
What is the final diagnosis based on?
What is the final diagnosis based on?
- Serum Vitamin B12 levels and red cell folate levels (correct)
- Serum iron levels
- Hemoglobin electrophoresis
- Blood smear analysis
What is hemoglobinopathy related to?
What is hemoglobinopathy related to?
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What is the normal percentage of HbA in adult hemoglobin?
What is the normal percentage of HbA in adult hemoglobin?
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Which of the following is a common finding in platelets in this condition?
Which of the following is a common finding in platelets in this condition?
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Study Notes
Megaloblastic Anemia
- Characterized by extremely low Hb and red cell count
- HCT may reflect the actual decrease in erythrocytes due to enlarged size of the red cells
- Marked increase in MCV, potentially up to 130fl
- MCH varies, but usually increased in 90% of cases
- RDW is increased
- TLC usually shows leucopenia, particularly neutropenia
- Platelet count is usually decreased, with some large platelets
- Peripheral blood smear features:
- Marked anisocytosis with macrocytic and normochromic cells
- Marked poikilocytosis with oval macrocytes, tear drop cells, and microcytes
- Basophilic stippling, Howell Jolly bodies, and nucleated red blood cells
- Neutrophils with hypersegmentation (6-10 lobes) and enlarged size
Hemoglobinopathies
- Represent inherited or genetic defects related to hemoglobin
- Defects can result in:
- Quantitative defects (e.g., thalassemia): deficiency in normal adult hemoglobin synthesis
- Qualitative defects (e.g., sickle cell anemia): abnormal structure of the hemoglobin molecule
- Normal adult hemoglobin composition:
- HbA (α2β2): 95%-98%
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