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Questions and Answers
What is a clinical feature of a fetus with anemia?
What is a potential complication of fetal anemia?
What is a characteristic of RBCs in a fetus with anemia?
What is a sign of fetal anemia?
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What is a feature of the bone marrow in a fetus with anemia?
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Study Notes
Iron Deficiency Anemia
- Iron storage, metabolism, and incorporation can lead to iron deficiency anemia
- Chronic inflammation can cause anemia
- Sideroblastic anemia is a type of anemia that can be hereditary or acquired
- Hereditary hemochromatosis can be homozygous or heterozygous
Laboratory Diagnosis
- Evaluation of heme synthesis is important for diagnosis
- Tests include:
- Free protoporphyrin
- Serum transferrin receptors
- Bone marrow evaluation
Anemia of Chronic Inflammation
- Causes include:
- Chronic inflammation
- Sideroblastic anemia
- Hereditary hemochromatosis
- Laboratory diagnosis involves:
- Indirect fluorescent antibody techniques
- Enzyme-linked immunosorbent assays
Hereditary Hemochromatosis
- Can cause damage to organs
- Laboratory diagnosis is crucial
- Homozygous and heterozygous forms exist
Thalassemia
- β-Thalassemia is a genetic disorder
- Silent carriers have nearly normal hemoglobin production
- Heterozygous individuals have moderate microcytic and hypochromic anemia
- homozygous β-thalassemia has severe symptoms
- Clinical features include:
- Microcytic and hypochromic anemia
- Hepatosplenomegaly
- Bone deformities
HbH Disease
- Caused by tetramers of β-globin chains
- Accumulation of β-globin chains leads to HbH formation
- Clinical features include:
- Microcytic and hypochromic anemia
- Reticulocytosis
- Hyperplasia of bone marrow
- Inclusion bodies and poikilocytosis in RBCs
Hb Bart Syndrome
- Caused by absence of β-globin production
- Hb Bart has high oxygen affinity and low delivery
- Clinical features include:
- Severe anemia
- Edema
- Ascites
- Hepatosplenomegaly
- Cardiomegaly
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Description
This quiz covers the different types of anemia, including iron deficiency anemia, chronic inflammation, and sideroblastic anemia. It also touches on iron metabolism and storage.
