Hematology and Coagulation Inhibitors

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the primary use of heparin in medical studies?

Cancer treatment

Coagulation studies

Hematological studies (correct)

Cardiac research

What is the natural source of heparin?

Liver

Blood (correct)

Pancreas

Kidney

What is the effect of heparin on prothrombin?

It inhibits its conversion to thrombin (correct)

It accelerates its conversion to thrombin

It converts thrombin to prothrombin

It has no effect on prothrombin

What is CBC an abbreviation for?

Complete Blood Count Signup and view all the answers

What is the primary function of thrombin in the blood?

To facilitate blood clotting Signup and view all the answers

Where is the enzyme Alanine Transferase primarily found?

Liver and kidney Signup and view all the answers

Which of the following enzymes is not often tested alongside ALT?

Pepsin Signup and view all the answers

What is the purpose of testing ALT and other liver enzymes?

To diagnose and monitor liver diseases Signup and view all the answers

What is the name of the enzyme often tested alongside ALT?

Aspartate Transaminase Signup and view all the answers

What is bilirubin?

A type of pigment Signup and view all the answers

What type of sample is ideal for blood glucose testing?

Serum or plasma Signup and view all the answers

What is the primary concern when handling blood glucose specimens?

Preventing bacterial contamination Signup and view all the answers

How long is glucose concentration stable in serum at 25°C?

8 hours Signup and view all the answers

At what temperature can glucose concentration remain stable for 72 hours?

4°C Signup and view all the answers

What happens to glucose concentration in hemolyzed serum?

It is unaffected Signup and view all the answers

What is one of the factors that affect PPG?

The amount and type of food Signup and view all the answers

What is the name of the hormone that raises blood glucose levels?

Glucagon Signup and view all the answers

What is the definition of Fasting Blood Glucose (FB)?

The level of blood glucose after 6-8 hours of fasting Signup and view all the answers

What is the opposite of glucagon in terms of its effect on blood glucose levels?

Insulin Signup and view all the answers

What is the primary factor that affects blood glucose levels?

The amount and type of food Signup and view all the answers

What type of tubes are used to obtain serum blood?

Yellow-top tubes Signup and view all the answers

What is the main purpose of using a yellow-top tube?

To collect serum blood Signup and view all the answers

What does PPG stand for in medical terminology?

Post Prandial Glucose Signup and view all the answers

What is PPG a measure of?

Plasma glucose concentration after eating Signup and view all the answers

What type of glucose level is PPG NOT a measure of?

Fasting glucose level Signup and view all the answers

Study Notes

Blood Collection Tubes with Anticoagulants

Mainly used for hematological studies, such as Complete Blood Count (CBC)
Example of anticoagulant: EDTA
Heparin: naturally present in blood, inhibits conversion of prothrombin to thrombin

Blood Collection Tubes without Anticoagulants

Used to obtain serum blood
Example: yellow-top tube

Blood Glucose Levels

Post Prandial Glucose (PPG) Level: plasma glucose concentration after eating
Factors affecting PPG:
- Amount and type of food
- Insulin and glucagon secretion
Fasting Blood Glucose (FB) Level: blood glucose level after 6-8 hours of fasting

Collecting and Handling Specimens for Blood Glucose Test

Use serum or plasma free of hemolysis
Glucose concentration stable in separate, non-hemolyzed serum for:
- Up to 8 hours at 25°C
- Up to 72 hours at 4°C, if kept free of bacterial contamination