Podcast
Questions and Answers
What triggers primary hemostasis upon blood vessel injury?
What triggers primary hemostasis upon blood vessel injury?
- Nucleated blood components
- Platelets
- Endothelial cell inflammatory proteins (correct)
- Subendothelial cholesterol
What is the normal range of platelets in women?
What is the normal range of platelets in women?
- 120-350x10^9/L
- 100-300x10^9/L
- 250-500x10^9/L (correct)
- 150-400x10^9/L
What factor recruits megakaryocyte progenitors from common myeloid progenitors?
What factor recruits megakaryocyte progenitors from common myeloid progenitors?
- Thrombopoietin (TPO) (correct)
- Leukopoietin
- Erythropoietin
- Monocytopoietin
Which cells act to balance megakaryocytopoiesis and erythropoiesis through their opposing actions?
Which cells act to balance megakaryocytopoiesis and erythropoiesis through their opposing actions?
What is the role of megakaryocytes in the bone marrow?
What is the role of megakaryocytes in the bone marrow?
In what type of patients are platelets slightly lower?
In what type of patients are platelets slightly lower?
Which progenitor stage is the most immature in the megakaryocyte lineage?
Which progenitor stage is the most immature in the megakaryocyte lineage?
What characterizes the progenitor stage of CFU-Meg Diploids?
What characterizes the progenitor stage of CFU-Meg Diploids?
Which transcription factors are associated with endomitosis in the megakaryocyte lineage?
Which transcription factors are associated with endomitosis in the megakaryocyte lineage?
What is a key feature of the terminal differentiation of a Promegakaryocyte into a Megakaryocyte (MK-I)?
What is a key feature of the terminal differentiation of a Promegakaryocyte into a Megakaryocyte (MK-I)?
Where do Megakaryocytes release platelets from during terminal differentiation?
Where do Megakaryocytes release platelets from during terminal differentiation?
What is the alternative name for the Eicosanoid synthesis pathway?
What is the alternative name for the Eicosanoid synthesis pathway?
Which enzyme converts arachidonic acid to prostaglandin G2 and prostaglandin H2?
Which enzyme converts arachidonic acid to prostaglandin G2 and prostaglandin H2?
What effect does TXA2 have on adenylate cyclase activity?
What effect does TXA2 have on adenylate cyclase activity?
What is the function of Prostacyclin in endothelial cells?
What is the function of Prostacyclin in endothelial cells?
Which pathway is triggered by G-proteins and involves phospholipase C activation?
Which pathway is triggered by G-proteins and involves phospholipase C activation?
What binds guanosine diphosphate (GDP) when G-proteins are inactive?
What binds guanosine diphosphate (GDP) when G-proteins are inactive?
What is the approximate size of a mature megakaryocyte (MK-III)?
What is the approximate size of a mature megakaryocyte (MK-III)?
Which transcription gene product suppresses megakaryocyte differentiation?
Which transcription gene product suppresses megakaryocyte differentiation?
What is the main growth factor responsible for inducing thrombocytopoiesis?
What is the main growth factor responsible for inducing thrombocytopoiesis?
Where are sequestered platelets mainly found?
Where are sequestered platelets mainly found?
Which platelets compensate for thrombocytopenia and have diameters larger than ordinary mature platelets?
Which platelets compensate for thrombocytopenia and have diameters larger than ordinary mature platelets?
Which zone of the platelet contains glycoproteins related to the coagulation and fibrinolytic systems?
Which zone of the platelet contains glycoproteins related to the coagulation and fibrinolytic systems?
What is the function of phospholipase C in the context described?
What is the function of phospholipase C in the context described?
What is the primary role of IP3 in the context described?
What is the primary role of IP3 in the context described?
What is the function of DAG in the context described?
What is the function of DAG in the context described?
What is the purpose of using EDTA in the platelet counting procedure described?
What is the purpose of using EDTA in the platelet counting procedure described?
What is the purpose of using a phase-contrast microscope in the platelet counting procedure described?
What is the purpose of using a phase-contrast microscope in the platelet counting procedure described?
