Chapter 12 TF

A mature red blood cell is a biconcave disk saturated with hemoglobin.

Erythropoietin is produced in the liver.

When oxygen transport to the tissues is impaired, erythropoietin activity decreases.

Hemoglobin is 95% saturated with oxygen in the tissues where oxygen tension is low.

Iron from the breakdown of hemoglobin is stored by the liver.

The CBC can only be used as a diagnostic tool for anemia.

Iron depletion is characterized by decreased or absent serum iron levels, but normal hemoglobin and hematocrit levels.

Without serial testing, red blood smear and red blood indices may mimic acute blood loss with a microcytic, hypochromic picture.

Pernicious anemia is primarily caused by inadequate vitamin B12 intake.

Aplastic anemia can be caused by exposure to toxic substances like arsenic and anticonvulsive drugs.

Pure red cell aplasia is characterized by only the absence of red blood cell precursors.

Pure red cell aplasia can be seen with lupus erythematosus and may require bone marrow transplantation.

Decreased alveolar oxygen tension results in complete arterial oxygen saturation.

Testosterone replacement therapy does not lead to a polycythemia response.

Excessive vomiting, diarrhea, or stress can cause a decrease in erythrocyte count.

Basophils contain heparin and histamine and are commonly found in non-allergic states.

Most circulating lymphocytes are T lymphocytes or B lymphocytes, which are responsible for producing antibodies.

Relative lymphocytosis is characterized by an increase in the lymphocyte count and a decrease in neutrophils.

Acute lymphocytic leukemia is more common in children and is the most curable type of leukemia.

Acute myelogenous leukemia commonly has a gradual onset at older ages and is curable with conventional chemotherapy.

Decreased platelet counts (thrombocytopenia) are observed in idiopathic thrombocytopenic purpura but not in polycythemia vera.

Petechiae and ecchymoses are manifestations of platelet disorders that can be observed on the skin.

Anticoagulant therapy with medications like heparin and Coumadin can be monitored using common laboratory tests.

The disease process of coagulation disorders predominantly affects females.

Von Willebrand's Disease is transmitted as a dominant trait.

Postpartum bleeding is not a common symptom of Von Willebrand's Disease.

Thrombocytopenia is characterized by decreased platelet levels.

Anemia can be caused by chronic disease.

Polycythemia vera results in increased levels of red blood cells.

Pernicious anemia is associated with elevated mean corpuscular volume (MCV).