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Heavy Metal Toxicity Overview

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Questions and Answers

What is the primary mechanism of acute arsenic toxicity?

Decreased production of glutathione

Decreased production of ATP (correct)

Increased production of reactive oxygen species

Decreased production of insulin

Which of the following is NOT a common gastrointestinal symptom of acute arsenic toxicity?

Metallic taste

Diarrhea

Garlic breath

Constipation (correct)

Which of the following is a common cardiovascular effect of acute arsenic toxicity?

Bradycardia

Prolonged QT interval (correct)

Atrial fibrillation

Decreased blood pressure

Which of the following is a common complication of chronic arsenic toxicity?

Peripheral sensory neuropathy Signup and view all the answers

Which of the following is a characteristic skin finding in chronic arsenic toxicity?

Hyperpigmentation and hyperkeratosis Signup and view all the answers

What is the first-line chelation therapy for acute arsenic toxicity?

Dimercaprol (BAL) Signup and view all the answers

Which of the following is NOT a primary use of cadmium?

Automotive fuel additives Signup and view all the answers

Which route of exposure is considered the primary pathway for cadmium absorption?

Inhalation of vapor and fumes Signup and view all the answers

Which of the following is NOT a manifestation of chronic cadmium nephrotoxicity?

Hypercalciuria Signup and view all the answers

Which organ serves as the primary reservoir for cadmium accumulation in the body?

Kidneys Signup and view all the answers

What is the approximate half-life of cadmium in the body?

7-30 years Signup and view all the answers

Which of the following is NOT a clinical manifestation of acute cadmium toxicity?

Peripheral neuropathy Signup and view all the answers

What is the most toxic form of arsenic?

Arsine gas Signup and view all the answers

Which of the following is NOT a use of inorganic arsenic compounds?

Fuel additives Signup and view all the answers

Which condition is associated with increased arsenic toxicity due to impaired metabolism?

Alcoholism Signup and view all the answers

What is the primary mechanism by which the body eliminates arsenic?

Renal excretion Signup and view all the answers

What is the primary mechanism by which arsenic causes toxicity?

Inhibition of pyruvate dehydrogenase, impairing gluconeogenesis Signup and view all the answers

Which route of exposure is associated with the highest absorption of arsenic?

Pulmonary (inhalation) Signup and view all the answers