Podcast
Questions and Answers
What is the role of the semilunar (SL) valves in the heart?
What is the role of the semilunar (SL) valves in the heart?
Isovolumetric contraction occurs when there is a change in volume in the heart.
Isovolumetric contraction occurs when there is a change in volume in the heart.
False
What type of muscle contractions do myocardial cells undergo?
What type of muscle contractions do myocardial cells undergo?
Involuntary contractions
The thick filaments in myocardial cells are primarily composed of __________.
The thick filaments in myocardial cells are primarily composed of __________.
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Match the following heart valve actions with their corresponding states:
Match the following heart valve actions with their corresponding states:
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What is the primary function of systemic circulation?
What is the primary function of systemic circulation?
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Myocardial infarction refers to reduced blood flow to the heart muscle.
Myocardial infarction refers to reduced blood flow to the heart muscle.
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What supplies the heart muscle with blood?
What supplies the heart muscle with blood?
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The heart weighs approximately ______ grams.
The heart weighs approximately ______ grams.
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Match the type of circulation with its description:
Match the type of circulation with its description:
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Which heart valve prevents backflow from the left ventricle to the left atrium?
Which heart valve prevents backflow from the left ventricle to the left atrium?
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What is the main purpose of the heart valves?
What is the main purpose of the heart valves?
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The first heart sound (S1) is caused by the closure of the semilunar valves.
The first heart sound (S1) is caused by the closure of the semilunar valves.
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What condition is characterized by the inflammation of the myocardium?
What condition is characterized by the inflammation of the myocardium?
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The space between the inner and outer pericardial membranes is filled with __________.
The space between the inner and outer pericardial membranes is filled with __________.
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Match the following conditions with their descriptions:
Match the following conditions with their descriptions:
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Which heart sound is associated with the closure of semilunar valves?
Which heart sound is associated with the closure of semilunar valves?
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What is the primary layer of the heart wall that consists of specialized cardiac muscle?
What is the primary layer of the heart wall that consists of specialized cardiac muscle?
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Heart murmurs are always a sign of a serious heart condition.
Heart murmurs are always a sign of a serious heart condition.
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What is the primary function of the specialized cardiac muscle conducting cells?
What is the primary function of the specialized cardiac muscle conducting cells?
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Nerve impulses and hormones are responsible for establishing the fundamental rhythm of the heart.
Nerve impulses and hormones are responsible for establishing the fundamental rhythm of the heart.
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What does the QRS complex represent in an ECG?
What does the QRS complex represent in an ECG?
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During ventricular systole, the pressure inside the ventricle is higher than in the ______.
During ventricular systole, the pressure inside the ventricle is higher than in the ______.
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Match the following ECG components with their associated activity:
Match the following ECG components with their associated activity:
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What percentage of ventricular filling occurs during passive ventricular filling?
What percentage of ventricular filling occurs during passive ventricular filling?
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The pressure in the aortic trunk is lower than that in the left ventricle during heart contraction.
The pressure in the aortic trunk is lower than that in the left ventricle during heart contraction.
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What happens to the pressure in the ventricle as it relaxes?
What happens to the pressure in the ventricle as it relaxes?
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The heart has intrinsic rhythmical electrical activity leading to continuous ______.
The heart has intrinsic rhythmical electrical activity leading to continuous ______.
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Which element modifies the timing and strength of each heart beat?
Which element modifies the timing and strength of each heart beat?
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Study Notes
Cardiovascular System 1
- Lecture aims: blood flow and circulation, heart structure, heart function
Blood Flow and Circulation
- Systemic and pulmonary circulation
- Blood flow through the heart
- Coronary circulation
Circulation
- Pulmonary circulation: blood travels from the heart to the lungs and back to the heart
- Systemic circulation: blood travels from the heart to the body and back to the heart
Blood flow through the heart
- Path of blood through the heart, including pulmonary capillaries of the right lung, right atrium, right ventricle, pulmonary capillaries of the left lung, left atrium, left ventricle, and capillaries of the trunk and lower limbs
- Key structures: pulmonary capillaries, right atrium, right ventricle, pulmonary capillaries of left lung, left atrium, left ventricle
- Movement of blood through the heart is related to the opening and closing of valves
Coronary Circulation
- Supplies heart muscle with blood
- High demand for oxygen and nutrients
- Diffusion through tissues is insufficient
- Vessels run in sulci (grooves) on the heart surface
Coronary Circulation: The Arteries
- Branches off aorta above aortic semilunar valve (at aortic sinuses)
- High pressure
- Elastic
Coronary Circulation: The Veins
- Run alongside arteries
- Collect waste from cardiac muscle
- Venous drainage mainly via coronary sinus (posterior), emptying into right atrium
Coronary Circulation: If It Goes Wrong
- Myocardial ischemia: reduced blood flow to myocardium
- Angina pectoris: associated pain
- Myocardial infarction (MI): complete obstruction of blood flow to part of myocardium
The Heart (Structure)
- Heart valves and sounds
- Heart tissue
The Heart: Overview
- Pump of the cardiovascular system
- Weighs approximately 250-300g
- Pumps 30 times its own weight (5L) per minute
- Muscular organ that never rests
- Contracts approximately 3 billion times during an average human lifetime
Thickness of Cardiac Walls
- Blood pressure (BP) in aorta is 120mmHg
- BP in pulmonary trunk is 30mmHg
- Why the difference?
Heart Valves
- Valves open to allow blood flow from atria into ventricles (atrioventricular valves: bicuspid (mitral) and tricuspid); and from ventricles into corresponding arteries (semilunar valves)
- Stenosis: narrowing of heart valves, restricting blood flow
Heart Sounds
- Sounds of heartbeat due to turbulence in blood flow and valve closure
- 1st heart sound (lubb) - S1 (closure of AV valves)
- 2nd heart sound (dubb) - S2 (closure of semilunar valves)
- S3 and S4 not usually loud enough to be heard
- Tool: Stethoscope
- Heart murmur: abnormal sounds sometimes due to valve disorder (e.g., mitral stenosis)
The Layers of the Heart Wall
- Endocardium (inner layer): lines chambers and valves, continuous with large blood vessels (thin squamous epithelium)
- Myocardium (muscle layer): specialized cardiac muscle (95% of wall)
- Epicardium (external layer): transparent outer layer, part of pericardium
Pericardium
- Double walled sac surrounding the heart
- Space between inner and outer pericardial membranes filled with pericardial fluid
- Lubrication, prevention of friction during heart beats
- Pericarditis: inflammation of pericardium
- Causes surfaces to rub together
- Distinct scratching sound heard through stethoscope
- Acute or chronic
Myocardium
- Cardiac muscle: muscle fibers swirl/spiral diagonally in interlacing bundles/networks.
The Heart (Function)
- Electrical conduction
- Volume and pressure
- The muscle cells
- Stroke volume and cardiac output
Heart: Electrical Activity, the conducting system
- Heart has intrinsic rhythmical electrical activity (continuous beating)
- Specialized cardiac muscle conducting cells (self-excitable)
- Fire spontaneously due to unstable membrane potential
- Act as pacemakers; set rhythm
- Form networks/path for spread of excitation through the heart
Volume & Pressure: 1. ECG, pressure
- ECG (electrocardiogram) relates to the electrical activity of the heart over time
- Pressure is measured in the heart and blood vessels
- Diagram shows pressure changes relating to the opening and closing of heart valves
Volume & Pressure: 2. Pressure Detail
- Pressure in ventricle higher than aortic and pulmonary trunk – SL valves open
- As ventricle relaxes, pressure drops and AV valves open
Volume & Pressure: 3. Volume Detail
- Pressure in atria higher than in ventricle – passive filling (70% ventricular capacity)
- Volume rises
Volume & Pressure: 4. Heart Sounds
- Heart valves closing produce the lubb-dubb sounds
Myocardium: The Muscle Cells
- Involuntary contractions
- Striated, branching fibers
- Connected by intercalated discs
- Single central nucleus
Myocardium: Histology
- Thick filaments: myosin
- Thin filaments: actin
- Contraction: myosin heads pull thin actin filaments, resulting in shortening of the sarcomere
- Length of individual thin and thick filaments does not change
- Shortening of sarcomere = shortening of muscle = contraction
Comparison to Skeletal Muscle
- Shorter (50-100 µm) and exhibit branching
- Usually one central nuclei
- Intercalated discs - contain gap junctions
- Many more mitochondria
- Same arrangement (actin, myosin, bands & discs)
- Less developed sarcoplasmic reticulum with smaller calcium stores
Stroke Volume
- End diastolic volume (EDV): volume in ventricle at end of diastole (approximately 130 mL)
- End systolic volume (ESV): volume in ventricle at end of systole (approximately 60 mL)
- Stroke volume (SV): volume ejected per beat from each ventricle (approximately 70 mL)
- SV = EDV - ESV
Cardiac Output
- Cardiac output (CO): amount of blood ejected by left ventricle per minute
- Determined by stroke volume and heart rate (CO = SV x HR)
- If SV = 70 mL/beat and HR = 75 beats/min, CO = 5250 mL/min
- Entire blood supply passes through circulatory system every minute
- Cardiac reserve: maximum output – output at rest (average = X4-5, athlete =X7-8)
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Description
This quiz tests your knowledge on the anatomy and function of the heart, including the role of heart valves, myocardial contractions, and circulation. Match heart valve actions to states and answer questions about cardiac health and structure. Perfect for students studying cardiovascular anatomy!