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Questions and Answers
What is meant by wound?
What is meant by wound?
A cut or break in the continuity of any tissue, caused by injury or operation, often associated by disruption of structure and function
Why is healing an important mechanism?
Why is healing an important mechanism?
What are the two distinct processes of healing?
What are the two distinct processes of healing?
Regeneration and Repair
Healing by repair better than regeneration?
Healing by repair better than regeneration?
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List three types of cells with regards to regeneration
List three types of cells with regards to regeneration
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In healing, what is the usual case with stable cells?
In healing, what is the usual case with stable cells?
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Name four components of the extracellular matrix:
Name four components of the extracellular matrix:
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Give three examples of local factors that influence wound healing
Give three examples of local factors that influence wound healing
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A high mitotic figure in a tissue specimen could indicate cancer growth?
A high mitotic figure in a tissue specimen could indicate cancer growth?
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How are nerve cells healed?
How are nerve cells healed?
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List the key stages of bone healing
List the key stages of bone healing
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Flashcards
Wound Healing
Wound Healing
The body's response to injury, aiming to restore integrity and function.
Types of Wounds
Types of Wounds
Wounds can be classified as tidy or untidy depending on their appearance and healing pattern.
Regeneration
Regeneration
Healing through the regeneration of parenchymal cells, restoring structure and function.
Repair
Repair
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Labile Cells
Labile Cells
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Stable Cells
Stable Cells
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Permanent Cells
Permanent Cells
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Factors Controlling Regeneration
Factors Controlling Regeneration
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Extracellular Matrix
Extracellular Matrix
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Local Factors in Healing
Local Factors in Healing
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General Factors in Healing
General Factors in Healing
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Insufficient Fibrosis
Insufficient Fibrosis
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Excessive Fibrosis
Excessive Fibrosis
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Excessive Contraction
Excessive Contraction
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Nerve Healing
Nerve Healing
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Bone Healing Steps
Bone Healing Steps
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Growth Factors
Growth Factors
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Aging and Healing
Aging and Healing
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Chronic Diseases Impact
Chronic Diseases Impact
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Scar Formation
Scar Formation
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Complications of Repair
Complications of Repair
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Infection in Healing
Infection in Healing
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Hemostasis
Hemostasis
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Joint Movement Limitation
Joint Movement Limitation
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Skin Wound Healing
Skin Wound Healing
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Post-Operative Healing
Post-Operative Healing
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Healing Timeline
Healing Timeline
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Wound Classification
Wound Classification
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Skin Cell Regeneration
Skin Cell Regeneration
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Organism Healing Variability
Organism Healing Variability
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Study Notes
Healing & Repair
- Healing is the body's response to injury to restore normal structure and function
- Healing involves two processes: regeneration and repair
- Regeneration involves the regeneration of parenchymal cells to restore original structure/function
- Repair occurs when tissues do not return to their normal structure and function, leading to scar formation
- Wound healing is a crucial mechanism for stopping bleeding, preventing infection, and restoring tissue integrity
- Wounds can be classified as tidy or untidy
- Tidy wounds involve clean, precise cuts
- Untidy wounds involve breaks due to injury (including torn, crushed tissues)
Types of Healing
- Primary union/healing by first intention occurs in surgically incised wounds
- These wounds are clean, uninfected, and have edges approximated by sutures
- Healing is characterized by limited death of epithelial and connective tissues
- Secondary union/healing by second intention occurs in untidy wounds
- These wounds have tissue loss and edges are not approximated surgically, resulting in a larger scar compared to a clean surgical incision
Regeneration
- Labile cells are actively dividing and undergo rapid regeneration in their normal state
- Stable cells do not divide actively under normal conditions; their division rate is variable in response to stimuli
- Permanent cells do not divide and cannot regenerate
Factors Controlling Regeneration
- Growth factors (e.g., EGF, FGF, IGF, PDGF)
- Hormones (e.g., ACTH, estrogen, growth hormone)
- Cell-cell interactions—signaling through integrins (specific cell membrane proteins)
- Contact with basement membranes
- Growth control is crucial in preventing cancer
Mechanisms Controlling Regeneration
- Growth factor receptor activation leads to intracellular signaling cascades
- Tyrosine kinases and other signaling pathways initiate protein synthesis and cell proliferation
- These cellular signaling cascades trigger growth regulatory proteins that control the cell cycle
Extracellular Matrix
- Collagen (types I, III, IV): scaffolding material
- Elastin
- Glycoproteins (e.g., fibronectin, tenascin)
- Proteoglycans (e.g., heparan sulfate proteoglycans)
- ECM supports tissue structure and function—it is vital for cellular function and wound healing
Skin Wounds
- Healing involves inflammatory, migratory, and proliferative phases
- Different wound types—e.g., surgical incisions, lacerations, pressure sores
- Complications of skin wound healing include infection, poor blood supply
Factors Influencing Wound Healing
- Local factors: wound type, size, location, infection, apposition, blood supply
- General factors: age, chronic diseases, nutritional deficiencies, medications (steroids)
Complications of Repair
- Insufficient fibrosis—wound dehiscence, hernia, ulceration
- Excessive fibrosis—cosmetic scarring (hypertrophic scars/keloids)
- Excessive contraction—limitation of joint movement (contractures), obstruction of tubes & channels (strictures)
Specialized Tissues Healing
- Muscles: heal by fibrosis
- Nerves: axons regenerate, but nerve cells do not regenerate (gliosis)
Bone Healing (Fracture Healing)
- Immediate: blood clot
- Hours: inflammation, neutrophils, macrophages
- Days: removal of dead tissue, granulation tissue formation, soft callus
- Weeks: calcium deposition, hard callus formation
- Months: remodeling, removal of irregular bone (osteoclasts)
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Description
Explore the processes of healing and repair in the body. This quiz covers the mechanisms of wound healing, types of wounds, and the classifications of healing such as primary and secondary union. Understand how the body restores tissue integrity after injury.