Healing & Repair Overview
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Questions and Answers

What is meant by wound?

A cut or break in the continuity of any tissue, caused by injury or operation, often associated by disruption of structure and function

Why is healing an important mechanism?

  • Protect from scaring (correct)
  • Protect from infection (correct)
  • Stop bleeding (correct)
  • What are the two distinct processes of healing?

    Regeneration and Repair

    Healing by repair better than regeneration?

    <p>False (B)</p> Signup and view all the answers

    List three types of cells with regards to regeneration

    <p>Labile cells, Stable cells and Permanent cells</p> Signup and view all the answers

    In healing, what is the usual case with stable cells?

    <p>Variable division rate (B)</p> Signup and view all the answers

    Name four components of the extracellular matrix:

    <p>Collagen, Elastin, Glycoproteins, Proteoglycans</p> Signup and view all the answers

    Give three examples of local factors that influence wound healing

    <p>Type, size, location of wound, Apposition, lack of movement, Infection: Suppuration, Gangrene, Tetanus</p> Signup and view all the answers

    A high mitotic figure in a tissue specimen could indicate cancer growth?

    <p>True (A)</p> Signup and view all the answers

    How are nerve cells healed?

    <p>By gliosis (C)</p> Signup and view all the answers

    List the key stages of bone healing

    <p>Immediate - Blood clot, Hours - inflammation, neutrophils &amp; macrophages, Removal of dead bone by osteoclasts, Days - Granulation tissue with osteoblasts and matrix (soft callus), Weeks - Deposition of Calcium (calcification) to form hard callus, Months - Remodeling - removal of excess irregular bone (osteoclasts)</p> Signup and view all the answers

    Flashcards

    Wound Healing

    The body's response to injury, aiming to restore integrity and function.

    Types of Wounds

    Wounds can be classified as tidy or untidy depending on their appearance and healing pattern.

    Regeneration

    Healing through the regeneration of parenchymal cells, restoring structure and function.

    Repair

    Healing outcome where tissues do not return to normal, resulting in scar formation.

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    Labile Cells

    Cells that actively divide under normal circumstances, allowing rapid regeneration.

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    Stable Cells

    Cells that do not normally divide rapidly but can regenerate at a variable rate when needed.

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    Permanent Cells

    Cells that are unable to divide or regenerate, like certain nerve cells.

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    Factors Controlling Regeneration

    Various complex factors including growth factors, hormones, and cellular interaction that affect the regeneration process.

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    Extracellular Matrix

    A network composed of collagen, elastin, glycoproteins, and proteoglycans that provides structural support in tissues.

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    Local Factors in Healing

    Factors that influence the healing process such as wound type, infection, and blood supply.

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    General Factors in Healing

    Broad factors affecting healing like age, health status, and chronic diseases.

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    Insufficient Fibrosis

    Insufficient scar formation leading to complications like wound dehiscence or ulceration.

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    Excessive Fibrosis

    Overproduction of scar tissue leading to issues like keloids or hypertrophic scars.

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    Excessive Contraction

    A healing complication resulting in limited joint movement or strictures in channels.

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    Nerve Healing

    Damage to axons can repair through regrowth, while nerve cells heal by gliosis since they cannot regenerate.

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    Bone Healing Steps

    Stages include blood clotting, inflammation, granulation tissue formation, and remodeling into hard callus.

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    Growth Factors

    Proteins like EGF, FGF, IGF, and PDGF that play significant roles in tissue repair and regeneration.

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    Aging and Healing

    Age influences how well tissues can heal, with older individuals often healing slower.

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    Chronic Diseases Impact

    Conditions like diabetes and arthritis can hinder effective wound healing due to underlying health issues.

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    Scar Formation

    The result of repair healing when tissue cannot restore its original structure and function.

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    Complications of Repair

    Issues arising from the healing process, including insufficient or excessive scarring.

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    Infection in Healing

    Infections during the healing process can severely affect recovery outcomes, causing further complications.

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    Hemostasis

    The process of preventing blood loss, which is the first step in wound healing.

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    Joint Movement Limitation

    Excessive contraction during healing can restrict movement in joints, impacting overall mobility.

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    Skin Wound Healing

    A special process where skin closes over a wound, often involving layers and granulation tissue.

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    Post-Operative Healing

    Healing following surgical procedures, which can be complicated by various factors like infection.

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    Healing Timeline

    The duration of healing varies significantly based on several factors including the type of tissue affected.

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    Wound Classification

    Identifying wounds as tidy or untidy to assess healing potential and treatment options.

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    Skin Cell Regeneration

    The capacity of skin cells to rapidly divide and replace damaged cells, crucial for wound healing.

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    Organism Healing Variability

    Different tissues and organs heal at different rates, impacting recovery times for injuries.

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    Study Notes

    Healing & Repair

    • Healing is the body's response to injury to restore normal structure and function
    • Healing involves two processes: regeneration and repair
    • Regeneration involves the regeneration of parenchymal cells to restore original structure/function
    • Repair occurs when tissues do not return to their normal structure and function, leading to scar formation
    • Wound healing is a crucial mechanism for stopping bleeding, preventing infection, and restoring tissue integrity
    • Wounds can be classified as tidy or untidy
    • Tidy wounds involve clean, precise cuts
    • Untidy wounds involve breaks due to injury (including torn, crushed tissues)

    Types of Healing

    • Primary union/healing by first intention occurs in surgically incised wounds
    • These wounds are clean, uninfected, and have edges approximated by sutures
    • Healing is characterized by limited death of epithelial and connective tissues
    • Secondary union/healing by second intention occurs in untidy wounds
    • These wounds have tissue loss and edges are not approximated surgically, resulting in a larger scar compared to a clean surgical incision

    Regeneration

    • Labile cells are actively dividing and undergo rapid regeneration in their normal state
    • Stable cells do not divide actively under normal conditions; their division rate is variable in response to stimuli
    • Permanent cells do not divide and cannot regenerate

    Factors Controlling Regeneration

    • Growth factors (e.g., EGF, FGF, IGF, PDGF)
    • Hormones (e.g., ACTH, estrogen, growth hormone)
    • Cell-cell interactions—signaling through integrins (specific cell membrane proteins)
    • Contact with basement membranes
    • Growth control is crucial in preventing cancer

    Mechanisms Controlling Regeneration

    • Growth factor receptor activation leads to intracellular signaling cascades
    • Tyrosine kinases and other signaling pathways initiate protein synthesis and cell proliferation
    • These cellular signaling cascades trigger growth regulatory proteins that control the cell cycle

    Extracellular Matrix

    • Collagen (types I, III, IV): scaffolding material
    • Elastin
    • Glycoproteins (e.g., fibronectin, tenascin)
    • Proteoglycans (e.g., heparan sulfate proteoglycans)
    • ECM supports tissue structure and function—it is vital for cellular function and wound healing

    Skin Wounds

    • Healing involves inflammatory, migratory, and proliferative phases
    • Different wound types—e.g., surgical incisions, lacerations, pressure sores
    • Complications of skin wound healing include infection, poor blood supply

    Factors Influencing Wound Healing

    • Local factors: wound type, size, location, infection, apposition, blood supply
    • General factors: age, chronic diseases, nutritional deficiencies, medications (steroids)

    Complications of Repair

    • Insufficient fibrosis—wound dehiscence, hernia, ulceration
    • Excessive fibrosis—cosmetic scarring (hypertrophic scars/keloids)
    • Excessive contraction—limitation of joint movement (contractures), obstruction of tubes & channels (strictures)

    Specialized Tissues Healing

    • Muscles: heal by fibrosis
    • Nerves: axons regenerate, but nerve cells do not regenerate (gliosis)

    Bone Healing (Fracture Healing)

    • Immediate: blood clot
    • Hours: inflammation, neutrophils, macrophages
    • Days: removal of dead tissue, granulation tissue formation, soft callus
    • Weeks: calcium deposition, hard callus formation
    • Months: remodeling, removal of irregular bone (osteoclasts)

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    Healing & Repair PDF

    Description

    Explore the processes of healing and repair in the body. This quiz covers the mechanisms of wound healing, types of wounds, and the classifications of healing such as primary and secondary union. Understand how the body restores tissue integrity after injury.

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