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17 Questions

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HDL Synthesis and Apo-AI

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Questions and Answers

What is the first step of HDL synthesis?

Production of Apo-AI (correct)

Formation of pre-beta HDL

Incorporation of cholesterol esters

Transfer of lipids between HDL and other lipoproteins

Which transporter is responsible for transferring cholesterol and phospholipids to pre-beta HDL?

ABCG1

ABCA1 (correct)

CETP

LCAT

What is the role of APO-AI in HDL synthesis?

Acts as a cofactor for LCAT (correct)

Allows the transfer of cholesterol to HDL in the liver

Catabolizes cholesterol in peripheral tissues

Transfers cholesterol to HDL in the circulation

What is the role of ABCG1 in HDL synthesis?

Transfers cholesterol in peripheral cells to HDL Signup and view all the answers

Which pathway involves the transfer of lipids between HDL and other lipoproteins?

CETP pathway Signup and view all the answers

What is the role of CETP in the exchange process?

To exchange cholesterol esters in HDL particles for triglycerides in VLDL and LDL Signup and view all the answers

What is the result of the action of hepatic lipases on triglyceride-rich HDL?

Release of Apo-AI Signup and view all the answers

What happens to Apo-A1 after being released from small HDL particles?

It gets degraded by the liver through an unknown mechanism Signup and view all the answers

What is the role of Apo-E in the uptake of HDL cholesterol by the liver?

It allows HDL particles to undergo uptake by the LDL receptors into the liver Signup and view all the answers

What is the consequence of SR-B1 deficiency?

Increased risk of atherosclerosis Signup and view all the answers

What is the hallmark in the development of the atherosclerotic plaque?

Formation of fatty streak Signup and view all the answers

Which factor is believed to trigger the formation of fatty streak in atherosclerosis?

Dyslipidemia Signup and view all the answers

What process comprises intimal thickening with subsequent accumulation of lipid-laden macrophages and extracellular matrix?

Progressive process of atherosclerotic plaque Signup and view all the answers

Which cells constitute the formation of the atheroma plaque in atherosclerosis?

Smooth muscle cells Signup and view all the answers

What can occur as a result of the expansion of atherosclerotic lesions?

Intra-plaque hemorrhage Signup and view all the answers

Which process plays an important role in both the delay and accelerated progression of atherosclerotic cardiovascular disease?

Arterial remodeling Signup and view all the answers

What is believed to trigger the formation of fatty streaks in atherosclerosis?

Endothelial dysfunction Signup and view all the answers