Bio3350 lecture 4
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Questions and Answers

What are the four phases of an action potential?

Resting potential, Rising phase (depolarisation), Overshoot, Falling phase (repolarisation)

What is the neural code for transferring information over long distances?

Frequency and discharge pattern

What causes the generation of an action potential?

Depolarisation of the membrane beyond a threshold

What is the purpose of patch-clamping in studying ion channels?

<p>To record from a single ion channel at a time</p> Signup and view all the answers

During which phase of the action potential does the Na+ current enter?

<p>Rising phase</p> Signup and view all the answers

When does the K+ current enter and peak during the action potential?

<p>Enters at the end of the Rising phase and peaks at the start of the Falling phase</p> Signup and view all the answers

What is the mechanism of inactivation for Na+ channels and what must happen for reactivation?

<p>&quot;Ball and chain&quot; mechanism; the potential must be repolarized for reactivation</p> Signup and view all the answers

What were the major contributions of Hodgkin and Huxley to the study of action potential?

<p>Studied the giant axon of the squid, determined the importance of the permeabilities of Na+ and K+, made a mathematical model</p> Signup and view all the answers

What is the significance of the voltage-clamp technique in studying the behavior of Na+ and K+ currents during an action potential?

<p>It allows measurement of Na+ and K+ currents activated during a change in membrane potential, and reveals the inactivation of Na+ current after depolarization.</p> Signup and view all the answers

What is the challenge in determining why the Na+ current seems to inactivate after depolarization?

<p>The challenge lies in understanding the mechanism of inactivation of Na+ channels, which is independent of the membrane potential.</p> Signup and view all the answers

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