37 Questions
Which of the following is an intrinsic cause of haemolytic anaemia?
G-6PD deficiency
Which of the following is an extrinsic cause of haemolytic anaemia?
Autoimmune disorder
What are the consequences of haemolytic anaemia?
High levels of bilirubin and LDH
Which type of autoimmune hemolytic anemia is characterized by an IgG autoantibody and is associated with lymphoma and collagen vascular diseases?
Warm antibody AIHA
What are the typical laboratory findings in the diagnosis of autoimmune hemolytic anemia?
Reticulocytosis and indirect hyperbilirubinemia
What are some common precipitating factors for sickling in sickle cell disease?
All of the above
What is the main function of haptoglobin in the body?
To mop up degenerative fragments of RBCs
Which of the following is NOT a microorganism discussed in the text?
Arthropods
What is the term used to describe microorganisms that temporarily reside in the human body?
Transient
Which discipline overlaps with clinical microbiology and is associated with peptic ulcer disease?
Bacteriology
Which of the following is NOT a category of parasitic worms?
Mosquitoes
Which of the following diseases is caused by prions?
CJD
Which of the following terms describes the presence of microorganisms on a body surface without causing damage to the host?
Colonization
Which of the following is NOT a component of the human microbiome?
Prions
What is the classification of fungi based on their cellular structure?
Eukaryotes
Which of the following is NOT a characteristic of viruses?
They can produce their own metabolic energy
What is the main characteristic of protozoa?
They can produce their own metabolic energy
What is the purpose of phenotypic analysis in microbiology?
To study the physical characteristics of an organism
Which of the following is NOT a predominant species in the large intestine?
Bifidobacterium bifidum
Which of the following is NOT a characteristic of the genitourinary tract microbiome?
High resistance to infection
Which of the following is a potential risk factor for disruption of the microbiome?
Underlying causes such as malnutrition
What is the main purpose of faecal microbiota transplant (FMT)?
To replace a dysfunctional microbiome
Which enzyme is involved in initiating replication and associates tightly with primase to make a Pol a/primase complex?
Pol a
Which enzyme is responsible for leading strand synthesis in eukaryotic DNA replication?
Pol e
Which enzyme is involved in primer removal and fills gaps during DNA replication?
Pol d
Which enzyme is responsible for replicating mitochondrial DNA?
Pol g
Which of the following proteins is responsible for separating the DNA strands in DNA replication?
DNA Helicase
What is the role of Single-Strand Binding (SSB) proteins in DNA replication?
To prevent the DNA strands from re-associating
Which enzyme is responsible for regulating the twisting of the DNA during DNA replication?
Topoisomerase
Which enzyme is responsible for synthesizing RNA primers during DNA replication?
Primase
Which enzyme is responsible for identifying and removing damaged bases in DNA?
DNA glycosylase
Which repair mechanism is responsible for replacing regions of damaged DNA of up to 30 bases in length?
Nucleotide excision repair
Which disorder is characterized by extreme sensitivity to light, skin cancer, and frequent secondary tumors?
Xeroderma Pigmentosum
Which repair mechanism is associated with predisposition to cancer and immunodeficiency syndromes?
Nonhomologous end-joining
Which of the following accurately describes the process of DNA replication in eukaryotes?
DNA replication in eukaryotes involves the disassembly and reassembly of nucleosomes.
Which of the following accurately describes the role of Telomerase in DNA replication?
Telomerase adds new nucleotides to the growing DNA strand.
Which of the following accurately describes the time required for DNA replication in different organisms?
DNA replication is faster in yeast compared to human cells.
Test your knowledge on haemolytic anaemia including its classification, pathogenesis of sickle cell anaemia, and the pathology of thalassaemia. This quiz is designed for Class Year 1 students of RCSI Royal College of Surgeons in Ireland.
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