Haematology Disorders: Leukaemia Epidemiology and Classification

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Questions and Answers

Which type of leukaemia is more common in males than females?

  • Acute lymphoblastic leukaemia (ALL)
  • Acute myeloblastic leukaemia (AML) (correct)
  • Chronic lymphocytic leukaemia (CLL)
  • Chronic myeloid leukaemia (CML)

Which type of leukaemia primarily affects older adults around 50 years of age?

  • Acute lymphoblastic leukaemia (ALL)
  • Acute myeloblastic leukaemia (AML) (correct)
  • Chronic lymphocytic leukaemia (CLL)
  • Chronic myeloid leukaemia (CML)

What is the most common malignancy in children and adolescents?

  • Chronic myeloid leukaemia (CML)
  • Acute lymphoblastic leukaemia (ALL) (correct)
  • Acute myeloblastic leukaemia (AML)
  • Chronic lymphocytic leukaemia (CLL)

Which characteristic is more pronounced in Acute Lymphoblastic Leukaemia (ALL) compared to Acute Myeloblastic Leukaemia (AML)?

<p>Lymphadenopathy (A)</p> Signup and view all the answers

What is the general prognosis for Acute Lymphoblastic Leukaemia (ALL) since the 1960s?

<p>Around 80% 5-year survival rate (B)</p> Signup and view all the answers

What is the WBC count indicative of Acute Leukaemias?

<p>&gt; 100,000/µL (D)</p> Signup and view all the answers

Which cells are primarily identified in the diagnosis of Acute Lymphoblastic Leukaemia (ALL)?

<p>Lymphoblasts (D)</p> Signup and view all the answers

What are the CNS manifestations commonly seen in Acute Leukaemias?

<p>Headache, vomiting, and nerve palsies (D)</p> Signup and view all the answers

What is the main effect of marrow expansion in Acute Leukaemias?

<p>Bone pain and tenderness (A)</p> Signup and view all the answers

Which risk factor is associated with Malignant diseases arising from bone marrow stem cells?

<p>Exposure to ionizing radiation (C)</p> Signup and view all the answers

Which of the following is a characteristic feature of acute myeloid leukemia (AML)?

<p>Neoplastic promyelocytes with abnormally coarse and numerous azurophilic granules (B)</p> Signup and view all the answers

What is the most common leukemia in adults, especially affecting those over 50 years old?

<p>Chronic lymphocytic leukemia (CLL) (C)</p> Signup and view all the answers

Which gene is associated with chronic myeloid leukemia (CML)?

<p>BCR-ABL fusion gene (D)</p> Signup and view all the answers

What is the characteristic finding in the peripheral blood of chronic lymphocytic leukemia (CLL)?

<p>Increased number of lymphocytes with dense nuclear chromatin and scant cytoplasmic borders (C)</p> Signup and view all the answers

Which cancer is characterized by the presence of several cells with bilobed nuclei and a cell containing multiple needle-like Auer rods?

<p>Acute myeloid leukemia (AML) (B)</p> Signup and view all the answers

Which leukemia is associated with the presence of 'smudge' cells in the peripheral blood during preparation of a slide?

<p>Chronic lymphocytic leukemia (CLL) (C)</p> Signup and view all the answers

Which leukemia is associated with a slowly progressive course and affects adults between 25-60 years old?

<p>Chronic myeloid leukemia (CML) (C)</p> Signup and view all the answers

What is the diagnostic feature of AML Myeloid blast cells?

<p>Red-staining rod-like structures (C)</p> Signup and view all the answers

What is the clinical feature associated with bleeding into skin due to the rupture of capillaries?

<p>Petechiae (A)</p> Signup and view all the answers

Which clinical feature is indicative of bleeding from mucous membranes?

<p>Epistaxis (D)</p> Signup and view all the answers

In bleeding disorders, what is indicative of bleeding into body cavities such as joint space and intracranial hemorrhage?

<p>Subarachnoid hemorrhage (B)</p> Signup and view all the answers

Which disorder can cause a reduction in platelet number leading to bleeding disorders?

<p>Thrombocytopenia (B)</p> Signup and view all the answers

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