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Questions and Answers

What role does Ran GDP play in the process described?

  • It promotes the release of cargo from the receptor. (correct)
  • It aids in the import of proteins into the nucleus.
  • It facilitates the binding of cargo to export receptors.
  • It binds to cargo directly.
  • Which of the following best describes the movement of cargo in the nuclear export process?

  • Cargo is transported into the nucleus and processed there.
  • Cargo moves from the cytosolic side to the nucleus.
  • Cargo binds to the receptor and is retained in the nucleus.
  • Cargo is released in the cytosol after binding to the export receptors. (correct)
  • What is the result of GTP hydrolysis in this export process?

  • It prevents the binding of Ran GTP to import proteins.
  • It enhances cargo binding to nuclear import receptors.
  • It stabilizes the export receptors in the nucleus.
  • It causes a conformational change in the protein complex. (correct)
  • Which component is responsible for relocating back to the nucleus post-export?

    <p>Ran GTP</p> Signup and view all the answers

    Which factor promotes the binding of cargo to export receptors?

    <p>Nuclear exit signals (NES)</p> Signup and view all the answers

    What happens after cargo is released from the receptor?

    <p>Ran GAP hydrolyzes GTP to GDP, leading to receptor recycling.</p> Signup and view all the answers

    How does Ran GTP contribute to cargo movement during the export process?

    <p>It promotes the formation of the cargo-export receptor complex.</p> Signup and view all the answers

    Which step occurs first in the nuclear export process?

    <p>Cargo binds to export receptors.</p> Signup and view all the answers

    What is the primary role of glycosylation in proteins?

    <p>To facilitate the folding of proteins</p> Signup and view all the answers

    Which mechanism uses vesicles to transport proteins?

    <p>Vesicular transport</p> Signup and view all the answers

    Which amino acid is commonly involved in N-linked glycosylation?

    <p>Asparagine</p> Signup and view all the answers

    What must occur for a transmembrane protein to be translocated across a membrane?

    <p>It must unfold.</p> Signup and view all the answers

    What process is facilitated by glucosyltransferase during protein folding?

    <p>Adding glucosyl groups to oligosaccharides</p> Signup and view all the answers

    What is the role of the nuclear lamina?

    <p>To provide structural support.</p> Signup and view all the answers

    What is the role of the oligosaccharide carbohydrate in relation to proteins?

    <p>They help stabilize the protein's structure</p> Signup and view all the answers

    Which amino acids are commonly found in nuclear localization signals?

    <p>Lysine and arginine</p> Signup and view all the answers

    What can trigger the unfolded protein response?

    <p>Accumulation of misfolded proteins</p> Signup and view all the answers

    What mechanism ensures that proteins remain in their folded states?

    <p>Continuous glucosyl trimming and adding</p> Signup and view all the answers

    Which of the following proteins facilitates the import process through the nuclear pore?

    <p>Nucleoporins</p> Signup and view all the answers

    Which component anchors the precursor oligosaccharide to the targeted protein?

    <p>Oligochol molecule</p> Signup and view all the answers

    How does protein import into the nucleus initiate?

    <p>Through GTP hydrolysis</p> Signup and view all the answers

    What triggers the exchange of GDP for GTP in protein transport?

    <p>Ran protein activation</p> Signup and view all the answers

    How does glycosylation affect protein aggregation?

    <p>It reduces aggregation by promoting proper folding</p> Signup and view all the answers

    What type of protein transport does not require energy?

    <p>Passive diffusion</p> Signup and view all the answers

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