Untitled Quiz

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What role does Ran GDP play in the process described?

It promotes the release of cargo from the receptor. (correct)
It aids in the import of proteins into the nucleus.
It facilitates the binding of cargo to export receptors.
It binds to cargo directly.

Which of the following best describes the movement of cargo in the nuclear export process?

Cargo is transported into the nucleus and processed there.
Cargo moves from the cytosolic side to the nucleus.
Cargo binds to the receptor and is retained in the nucleus.
Cargo is released in the cytosol after binding to the export receptors. (correct)

What is the result of GTP hydrolysis in this export process?

It prevents the binding of Ran GTP to import proteins.
It enhances cargo binding to nuclear import receptors.
It stabilizes the export receptors in the nucleus.
It causes a conformational change in the protein complex. (correct)

Which component is responsible for relocating back to the nucleus post-export?

Ran GTP (D) Signup and view all the answers

Which factor promotes the binding of cargo to export receptors?

Nuclear exit signals (NES) (A) Signup and view all the answers

What happens after cargo is released from the receptor?

Ran GAP hydrolyzes GTP to GDP, leading to receptor recycling. (D) Signup and view all the answers

How does Ran GTP contribute to cargo movement during the export process?

It promotes the formation of the cargo-export receptor complex. (D) Signup and view all the answers

Which step occurs first in the nuclear export process?

Cargo binds to export receptors. (C) Signup and view all the answers

What is the primary role of glycosylation in proteins?

To facilitate the folding of proteins (B) Signup and view all the answers

Which mechanism uses vesicles to transport proteins?

Vesicular transport (A) Signup and view all the answers

Which amino acid is commonly involved in N-linked glycosylation?

Asparagine (A) Signup and view all the answers

What must occur for a transmembrane protein to be translocated across a membrane?

It must unfold. (B) Signup and view all the answers

What process is facilitated by glucosyltransferase during protein folding?

Adding glucosyl groups to oligosaccharides (A) Signup and view all the answers

What is the role of the nuclear lamina?

To provide structural support. (B) Signup and view all the answers

What is the role of the oligosaccharide carbohydrate in relation to proteins?

They help stabilize the protein's structure (A) Signup and view all the answers

Which amino acids are commonly found in nuclear localization signals?

Lysine and arginine (B) Signup and view all the answers

What can trigger the unfolded protein response?

Accumulation of misfolded proteins (C) Signup and view all the answers

What mechanism ensures that proteins remain in their folded states?

Continuous glucosyl trimming and adding (C) Signup and view all the answers

Which of the following proteins facilitates the import process through the nuclear pore?

Nucleoporins (C) Signup and view all the answers

Which component anchors the precursor oligosaccharide to the targeted protein?

Oligochol molecule (D) Signup and view all the answers

How does protein import into the nucleus initiate?

Through GTP hydrolysis (C) Signup and view all the answers

What triggers the exchange of GDP for GTP in protein transport?

Ran protein activation (C) Signup and view all the answers

How does glycosylation affect protein aggregation?

It reduces aggregation by promoting proper folding (A) Signup and view all the answers

What type of protein transport does not require energy?

Passive diffusion (D) Signup and view all the answers

Protein Sorting

The process of delivering newly synthesized proteins to their proper locations within the cell.

Protein Translocators

Protein channels that assist in moving proteins across membranes.

Vesicular Transport

Movement of proteins within vesicles that bud off from one membrane and fuse with another.

Nuclear Pore

A complex structure in the nuclear membrane that allows specific molecules to pass between the nucleus and cytoplasm.