Podcast
Questions and Answers
What is the primary mechanism by which growth hormone agonists exert their effects?
What is the primary mechanism by which growth hormone agonists exert their effects?
- Blocking the action of somatostatin.
- Directly binding to GH receptors on target tissues. (correct)
- Stimulating the release of insulin-like growth factor 1 (IGF-1) from the liver
- Inhibiting the production of catabolic hormones.
Why is the presence of closed epiphyses considered a contraindication for growth hormone agonist therapy?
Why is the presence of closed epiphyses considered a contraindication for growth hormone agonist therapy?
- GH agonists are ineffective in individuals with open epiphyses.
- Closed epiphyses indicate that natural growth is completed, and further GH stimulation is ineffective and potentially harmful. (correct)
- GH agonists can cause the epiphyses to close prematurely.
- Closed epiphyses indicate an increased risk of developing antibodies against the growth hormone
Which of the following is a potential adverse effect associated with growth hormone agonist therapy?
Which of the following is a potential adverse effect associated with growth hormone agonist therapy?
- Increased adrenal function.
- Decreased risk of injection site reactions
- Improved glucose tolerance.
- Development of antibodies that inactivate the hormone replacement. (correct)
In which of the following conditions would growth hormone agonists be indicated?
In which of the following conditions would growth hormone agonists be indicated?
Why should caution be exercised when administering growth hormone agonists to patients with underlying cranial lesions?
Why should caution be exercised when administering growth hormone agonists to patients with underlying cranial lesions?
Which of the following drug interactions is a concern when using growth hormone agonists?
Which of the following drug interactions is a concern when using growth hormone agonists?
Why might the use of growth hormone agonists be considered an abuse in the body building industry?
Why might the use of growth hormone agonists be considered an abuse in the body building industry?
What is the relationship between glucocorticoids and growth hormone agonists?
What is the relationship between glucocorticoids and growth hormone agonists?
Which of the following adverse effects of growth hormone agonists is most related to water balance?
Which of the following adverse effects of growth hormone agonists is most related to water balance?
A patient on somatropin reports symptoms of fatigue, weight gain, and constipation. Which potential adverse effect should the healthcare provider suspect?
A patient on somatropin reports symptoms of fatigue, weight gain, and constipation. Which potential adverse effect should the healthcare provider suspect?
Flashcards
Growth Hormone Agonists: Core Purpose
Growth Hormone Agonists: Core Purpose
Stimulates overall growth and production of protein by directly binding to GH receptors on target tissues.
Names of GH Agonists
Names of GH Agonists
Somapacitan and Somatropin.
Indications of GH Agonists
Indications of GH Agonists
Treatment of GH deficiencies. Can be abused in the body building industry.
Contraindications of GH Agonists
Contraindications of GH Agonists
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Cautions with GH Agonists
Cautions with GH Agonists
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Drug-Drug Interactions with GH Agonists
Drug-Drug Interactions with GH Agonists
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Adverse Effects of GH Agonists
Adverse Effects of GH Agonists
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Study Notes
- Growth Hormone Agonists stimulate overall growth and protein production by directly binding to GH receptors on target tissues.
Names
- Somapacitan
- Somatropin
Indications
- Used for the treatment of GH deficiencies
- Can be abused in the body building industry
Adverse Effects
- Injection site reactions
- Edema
- Myalgia
- Arthralgia
- Development of antibodies that inactivate the hormone replacement
- Hypoadrenalism
- Hypothyroidism
- Pancreatitis
Contraindication
- Known allergy
- Presence of closed epiphyses (growth plates), indicating that natural growth is finished
Cautions
- Underlying cranial lesions
- Acute critical illness
- Glucose intolerance
Drug-Drug
- Glucocorticoids
- Drugs using the cytochrome P450
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