5 Questions
What is the mode of infection for human type Mycobacterium tuberculosis?
Inhalation
Where can primary infection by Mycobacterium tuberculosis occur?
Lungs
What is the central area of large multinucleated giant cells containing tuberculin bacilli called?
Langhans Giant Cell
What form of tuberculosis develops in a previously unexposed and unsensitized person?
Primary tuberculosis
Which type of immune response resists the growth and spread of Mycobacterium tuberculosis?
Cell-mediated immune response
Study Notes
Granuloma Definition and Characteristics
- A type of chronic inflammation characterized by the formation of a small nodule composed of epithelioid cells and other cells of chronic inflammation, including lymphocytes, plasma cells, eosinophils, and fibroblasts.
- A small-sized nodule formation is a key feature of granuloma.
Types of Granulomata
- Infective granulomata: caused by bacteria, parasites, or fungi.
- Infective granulomata causes:
- Bacterial: Tuberculosis, Leprosy
- Parasitic: Schistosomiasis
- Fungal: Histoplasmosis, Blastomycosis
Foreign Body Granulomas
- Caused by the presence of foreign substances in the body.
- Types of foreign body granulomas:
- Endogenous: keratin, necrotic bone or adipose tissue, uric acid crystals
- Exogenous: wood, silica, asbestos, silicone, suture, talc powder
Granulomata of Unknown Cause
- Sarcoidosis is a type of granuloma of unknown cause.
Mechanism of Granuloma Formation
- Type IV cell-mediated delayed type hypersensitivity reaction is the mechanism of granuloma formation.
Tuberculosis Definition and Characteristics
- A chronic infective granulomatous disease caused by Mycobacterium tubercle bacilli.
- Usually affects the lungs, but may affect any organ or tissue in the body.
- An example of an infective granuloma.
Test your knowledge of granuloma types and their causes with this quiz. Learn about the differences between infective and foreign body granulomas, and the various microorganisms and foreign bodies that can lead to their formation.
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