Gram-Negative Sepsis Overview

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Questions and Answers

What is another name for Gram-Negative Sepsis?

  • Toxic Shock Syndrome
  • Vasodilatory Shock
  • Endotoxin Shock (correct)
  • Bacterial Shock

What effect do endotoxins have on blood pressure?

  • Stabilize blood pressure
  • Have no effect on blood pressure
  • Increase blood pressure significantly
  • Cause a severe drop in blood pressure (correct)

Why can antibiotics worsen the condition of Gram-Negative Sepsis?

  • They lower blood pressure further
  • They cause allergic reactions in patients
  • They kill bacteria, releasing more endotoxins (correct)
  • They directly neutralize endotoxins

Which components are involved in the treatment of Gram-Negative Sepsis?

<p>Neutralizing LPS components and inflammatory cytokines (A)</p> Signup and view all the answers

Which of the following is NOT true about endotoxins?

<p>They can only be neutralized by antibiotics (A)</p> Signup and view all the answers

Flashcards

Gram-Negative Sepsis Alternative Name

Endotoxin Shock

Endotoxin Effect on BP

Causes a significant drop in blood pressure.

Antibiotics in Gram-Negative Sepsis

Antibiotics can worsen the condition by releasing more toxins.

Gram-Negative Sepsis Treatment Components

Neutralizing LPS components and inflammatory cytokines.

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Endotoxin Neutralization Only by Antibiotics

False, endotoxins are not neutralized ONLY by antibiotics.

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Endotoxin Shock symptoms

Shock as a result of severe drop in blood pressure.

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LPS components

Components of bacterial cell walls that trigger a powerful inflammatory response.

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Inflammatory Cytokines

Signaling molecules that amplify the inflammatory response.

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Antibiotic role in sepsis

Antibiotics can worsen the condition by releasing more toxins.

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Endotoxins

Harmful substances produced by bacteria.

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Study Notes

Gram-Negative Sepsis

  • Also known as endotoxin shock, gram-negative sepsis is a serious condition caused by endotoxins
  • Endotoxins, specifically lipopolysaccharides (LPS), are released from the outer membrane of gram-negative bacteria
  • The presence of endotoxins in the bloodstream triggers a cascade of events that lead to a severe drop in blood pressure, known as septic shock
  • This drop in blood pressure can be life-threatening, leading to organ failure and death
  • Antibiotic treatment is often used to combat gram-negative bacterial infections, however, killing the bacteria can paradoxically worsen the condition by releasing more endotoxins
  • Treatment strategies focus on neutralizing the LPS components and the inflammatory-causing cytokines that contribute to the detrimental effects of endotoxin shock

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