Gram-Negative Bacteria Overview
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Questions and Answers

Which disease is primarily caused by Legionella?

  • Tularemia
  • Brucellosis
  • Whooping cough
  • Legionnaires' disease (correct)
  • Which species of Brucella is associated with cattle?

  • B.canis
  • B.abortus (correct)
  • B.melitensis
  • B.suis
  • What type of infections does Pseudomonas aeruginosa primarily cause?

  • Nosocomial infections (correct)
  • Zoonotic infections
  • Respiratory tract infections
  • Mild pertussis-like illness
  • Which of the following organisms is primarily associated with tularemia?

    <p>Francisella tularensis (B)</p> Signup and view all the answers

    Which disease is transmitted from animals to humans and is caused by Brucella?

    <p>Brucellosis (A)</p> Signup and view all the answers

    What is the primary cause of neonatal meningitis within the first month of life?

    <p>E. coli (C)</p> Signup and view all the answers

    Which symptoms are characteristic of gastroenteritis caused by Salmonella?

    <p>Nausea, vomiting, and diarrhea (C)</p> Signup and view all the answers

    What percentage of patients with enteric (typhoid) fever may have a faint maculopapular rash on the trunk?

    <p>30% (A)</p> Signup and view all the answers

    Which of the following organisms is known to primarily cause gastrointestinal diseases?

    <p>Yersinia (B)</p> Signup and view all the answers

    What bacterium is primarily responsible for causing enteric (typhoid) fever?

    <p>Salmonella serotype typhi (D)</p> Signup and view all the answers

    What type of bacteria are most of the organisms found in the gastrointestinal tract?

    <p>Gram-positive anaerobes (C)</p> Signup and view all the answers

    What type of lesions do Campylobacter typically cause in the intestine?

    <p>Ulcerative inflammatory lesions (D)</p> Signup and view all the answers

    Which Gram-negative rod is part of the normal microbiota but can also be pathogenic?

    <p>E.coli (A)</p> Signup and view all the answers

    Which toxin is associated with Shigella and contributes to its pathogenicity?

    <p>Shiga toxin (B)</p> Signup and view all the answers

    What characteristic is common among members of the genus Acinetobacter?

    <p>They are important nosocomial pathogens. (C)</p> Signup and view all the answers

    What is a common characteristic of Shigella species infections?

    <p>Diarrhea with blood and mucus (B)</p> Signup and view all the answers

    Which type of endotoxin is produced by organisms in the gastrointestinal tract?

    <p>Lipopolysaccharide (A)</p> Signup and view all the answers

    What shape best describes members of the genus Vibrio?

    <p>Curved, rod-shaped (B)</p> Signup and view all the answers

    Which organism is primarily responsible for infections outside the gastrointestinal tract?

    <p>Klebsiella (C)</p> Signup and view all the answers

    What mechanism is frequently important for E.coli to adhere to host surfaces?

    <p>Fimbriae or pili (A)</p> Signup and view all the answers

    Which of the following is true about the transmission of organisms that cause GI diseases?

    <p>Fecal contamination frequently plays a significant role. (D)</p> Signup and view all the answers

    What is the most important virulence factor of Neisseria meningitidis?

    <p>Polysaccharide capsule (D)</p> Signup and view all the answers

    Which symptoms are characteristic of meningitis caused by N. meningitidis?

    <p>Severe headache and vomiting (C)</p> Signup and view all the answers

    What is the primary clinical presentation of cholera?

    <p>Profuse watery diarrhea (D)</p> Signup and view all the answers

    What is the primary method by which N. meningitidis spreads to cause disease?

    <p>Via respiratory droplets (B)</p> Signup and view all the answers

    Which species of Yersinia is primarily responsible for bubonic plague?

    <p>Yersinia pestis (D)</p> Signup and view all the answers

    Which vaccine has replaced the quadrivalent polysaccharide vaccine in the United States?

    <p>MCV4 (A)</p> Signup and view all the answers

    Which of the following statements about meningococcal septicemia is true?

    <p>It can develop in less than twelve hours. (D)</p> Signup and view all the answers

    How does Helicobacter species primarily affect the human body?

    <p>Induces acute gastritis and ulcers (B)</p> Signup and view all the answers

    What is the most common form of plague presented clinically?

    <p>Bubonic/septicemic plague (B)</p> Signup and view all the answers

    Which of the following groups is at higher risk for meningococcal disease?

    <p>Young children (C)</p> Signup and view all the answers

    What distinguishes the conjugate meningococcal vaccines from serogroup B vaccines?

    <p>Conjugate vaccines target multiple serogroups. (B)</p> Signup and view all the answers

    Which organism is a leading cause of bacterial meningitis in infants and young children?

    <p>Haemophilus influenzae (A)</p> Signup and view all the answers

    What significant impact has the H.influenzae type b vaccine had?

    <p>Dramatically decreased frequency of H.influenzae infections (C)</p> Signup and view all the answers

    Which of the following is a common laboratory finding when isolating N. meningitidis?

    <p>Presence of encapsulated bacteria (A)</p> Signup and view all the answers

    Which disease is caused by Bordetella pertussis?

    <p>Whooping cough (D)</p> Signup and view all the answers

    What characteristic is associated with Helicobacter organisms?

    <p>They exhibit rapid corkscrew motility (C)</p> Signup and view all the answers

    What is the most common symptom of a gonococcal infection in females?

    <p>Greenish-yellow cervical discharge (C)</p> Signup and view all the answers

    What complication can result from untreated gonococcal salpingitis in women?

    <p>Fibrosis and infertility (D)</p> Signup and view all the answers

    What condition may develop in a newborn from passage through an infected birth canal?

    <p>Ophthalmia neonatorum (C)</p> Signup and view all the answers

    In which individuals is N. meningitidis most likely to cause outbreaks of meningitis?

    <p>Those in close contact settings like schools and military barracks (C)</p> Signup and view all the answers

    What is a potential result of untreated gonococcal conjunctivitis in newborns?

    <p>Permanent blindness (C)</p> Signup and view all the answers

    What is the primary treatment utilized for ophthalmia neonatorum caused by gonococcus?

    <p>Erythromycin (D)</p> Signup and view all the answers

    What symptom is characteristic of a severe strain of N. meningitidis infection with meningococcemia?

    <p>Fulminant meningococcemia with circulatory collapse (A)</p> Signup and view all the answers

    Why does gonococcus not survive long outside the human body?

    <p>It is highly sensitive to dehydration (B)</p> Signup and view all the answers

    Flashcards

    Salmonellosis

    A bacterial infection that can cause various diseases, including gastroenteritis and typhoid fever.

    Gastroenteritis

    Inflammation and infection of the lining of the intestines, typically caused by contaminated food or water.

    Typhoid Fever

    A severe, life-threatening systemic illness caused by Salmonella typhi, characterized by fever, abdominal pain, and a potential rash.

    Campylobacter

    Spiral-shaped bacteria that can infect the intestines, causing inflammation and ulcerative lesions.

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    Shigella

    A bacterial genus that causes shigellosis, a severe form of dysentery characterized by bloody diarrhea, abdominal cramps, and fever.

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    Vibrio

    Short, curved, rod-shaped bacteria that can cause various infections, including food poisoning, diarrhea, and wound infections.

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    Shiga Toxin

    A toxin produced by Shigella bacteria that has both damaging and toxic effects on the intestines.

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    Bacillary Dysentery

    A severe intestinal inflammation and infection characterized by bloody diarrhea, abdominal cramps, and fever, commonly caused by Shigella species.

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    Why is the meningococcal polysaccharide capsule important?

    Meningococcal polysaccharide capsule is a critical factor for the bacteria's survival and infection. It prevents the host's immune cells from engulfing and destroying the bacteria.

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    How does N. meningitidis infection begin?

    N. meningitidis primarily colonizes the nasopharynx, causing a largely asymptomatic infection. However, in vulnerable individuals, it can spread through the bloodstream causing serious complications.

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    What is meningitis?

    Meningitis is characterized by inflammation of the meninges, the membranes surrounding the brain and spinal cord. This inflammation leads to severe symptoms like headache, stiff neck, sensitivity to light, and even coma.

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    What is meningococcal septicemia?

    Meningococci can rapidly multiply in the bloodstream, causing a life-threatening septicemia. This condition can lead to severe blood poisoning and damage to organs.

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    What is MCV4?

    MCV4 is a vaccine that helps protect against meningococcal disease caused by serogroups A, C, W-135, and Y.

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    What is meningococcal disease?

    Meningococcal disease is any illness caused by Neisseria meningitidis. It can be prevented with vaccines like MenACWY and MenB.

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    Describe Moraxella bacteria.

    Moraxella are gram-negative bacteria that typically appear in pairs. They are commonly found in the environment and can sometimes cause infection.

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    What is meningococcemia?

    Meningococcemia is a rapid multiplication of meningococci in the bloodstream. It can lead to serious complications like meningitis and septicemia.

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    Yersinia

    A genus of bacteria that includes Y. enterocolitica and Y. pseudotuberculosis, which can cause gastrointestinal infections. It also includes Y. pestis, the causative agent of bubonic plague.

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    Y. pestis

    A member of the Enterobacteriaceae family that is responsible for plague, a serious infectious disease that can be spread through flea bites or direct contact with infected animals.

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    Bubonic Plague

    A common form of plague that often presents as swollen lymph nodes (buboes) in the groin, armpit, or neck.

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    Helicobacter

    A genus of bacteria known for its curved or spiral shape and ability to cause gastritis and ulcers in the stomach and duodenum.

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    Haemophilus

    A genus of bacteria known for its ability to cause meningitis, a serious infection of the membranes surrounding the brain and spinal cord.

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    Bordetella

    A genus of bacteria known for causing whooping cough, a highly contagious respiratory infection characterized by a distinctive cough.

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    Legionella

    A genus of bacteria famous for causing Legionnaires' disease, a type of pneumonia that can be severe.

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    H. influenzae

    A common bacterium that can cause meningitis, especially in infants and young children. A vaccine has significantly reduced the frequency of this infection.

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    What infections can Moraxella cause?

    These bacteria are a common cause of various infections, including respiratory, ear, eye, brain and spinal cord, and joint infections.

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    What is Acinetobacter and where is it often found?

    Acinetobacter are nonmotile, rod-shaped bacteria that are often found in hospitals and can cause infections, particularly in patients with weakened immune systems.

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    What is the primary habitat of Enterobacteriaceae?

    These bacteria are commonly found in the digestive system of humans and animals, and they can cause both gastrointestinal and extraintestinal diseases.

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    Where can enteric gram-negative rods cause disease?

    Enteric gram-negative rods can cause diseases in both the digestive system and other parts of the body.

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    What is the primary habitat and potential for disease of E. coli?

    Escherichia coli is a common resident of the colon, but it can also cause infections both within and outside the digestive tract.

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    Which bacteria are considered primary pathogens?

    Salmonella, Shigella, and Yersinia are considered pathogens because they are the primary causes of specific diseases.

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    Which bacteria are considered opportunistic pathogens?

    E. coli, Klebsiella, Serratia, Proteus, and Enterobacter are considered opportunistic pathogens because they can cause disease specifically in immunocompromised individuals.

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    What are some characteristics of E. coli?

    E. coli has fimbriae, hair-like structures that help it attach to the lining of the digestive tract, and it produces acid and gas during fermentation.

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    Pili

    Tiny hair-like structures found on the surface of some bacteria. They help attach the bacteria to surfaces like host cells, aiding in colonization and infection.

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    Gonorrhea Symptoms

    Gonococcal infection is characterized by a painful, yellow pus-like discharge from the urethra in males. Females experience a greenish-yellow discharge from the cervix, which may also lead to bleeding between periods. It can progress to pelvic inflammatory disease (PID) and even infertility.

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    Salpingitis

    Inflammation of the fallopian tubes, often a complication of gonorrhea infection in women. It can lead to scarring and infertility.

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    Ophthalmia Neonatorum

    An infection of the conjunctiva (the membrane lining the eyelid) contracted by a newborn during birth from an infected mother. Untreated, it can lead to blindness.

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    Meningococcal Meningitis

    A type of bacterial meningitis caused by Neisseria meningitidis. This infection can progress rapidly and cause a severe form of blood poisoning, circulatory collapse, and even death.

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    Fulminant Meningococcemia

    A serious blood infection caused by Neisseria meningitidis, characterized by rapid onset and severe symptoms like clotting problems, low blood pressure, and shock. While inflammation of the brain and spinal cord (meningitis) is not always present, this infection can be life-threatening.

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    Neisseria meningitidis Transmission

    Neisseria meningitidis is more likely to cause meningitis in crowded environments like schools, institutions, or military barracks, especially during colder months. Outbreaks are also more frequent in developing nations.

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    Meningococcal Pneumonia

    A type of pneumonia caused by Neisseria meningitidis, often characterized by high fever, coughing, and chest pain.

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    Brucella

    A genus of bacteria that primarily infects animals, causing a disease known as brucellosis, also called undulant fever. This zoonotic disease can be transmitted to humans from infected animals.

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    Pseudomonas aeruginosa

    A species of bacteria that is widely distributed in the environment and is a significant opportunistic pathogen, often causing infections in hospitals (nosocomial infections).

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    Tularemia

    A zoonotic disease caused by the bacterium Francisella tularensis, primarily affecting animals. It is also known as rabbit fever or deerfly fever because it can be transmitted through contact with infected animals or insects.

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    Bacteroides

    A genus of anaerobic gram-negative bacteria, known to cause peritonitis, an inflammation of the peritoneum (the lining of the abdominal cavity)

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    Study Notes

    Gram-Negative Bacteria

    • Gram-negative bacteria are a large group of bacteria.
    • Gram-negative bacteria can cause a wide range of diseases in humans.
    • Some bacteria can cause infection in the respiratory system.
    • Some bacteria can cause infection of the genitourinary tract.
    • Some bacteria can cause infection of the gastrointestinal tract.

    Cocci/Coccobacilli

    • Neisseria are nonmotile, gram-negative coccobacilli.
    • Neisseria are commonly found in pairs (diplococci).
    • Neisseria are aerobic.
    • Neisseria gonorrhoeae causes gonorrhea.
    • Neisseria meningitidis causes meningitis.
    • Moraxella are nonmotile, gram-negative coccobacilli.
    • Moraxella are generally found in pairs.
    • Moraxella can cause infections in the respiratory system, middle ear, eye, CNS, and joints.
    • Haemophilus : causes meningitis,
    • Bordetella : causes whooping cough
    • Legionella : causes pneumonia

    Bacilli

    • Bacilli are rod-shaped gram-negative bacteria.
    • Bacilli can be facultative (grow in the presence or absence of oxygen).
    • Bacilli can be aerobic or anaerobic (only grow in the absence of oxygen).
    • Enterobacteriaceae : a family of gram-negative bacilli found in humans
    • Escherichia coli: a common member of the enteric bacteria family; can cause intestinal and extraintestinal diseases
    • Salmonella: a genus, which can cause gastrointestinal diseases
    • Shigella: cause shigellosis (bacillary dysentery)
    • Campylobacter: causes acute enteritis
    • Vibrio: causes cholera
    • Klebsiella, Serratia, Proteus, Providencia, Morganella hafnia: primarily causing extraintestinal disease

    Pathogenesis

    • The source of infection for extraintestinal disease is frequently the patient's own flora.
    • Pathogens can cause disease in individuals when found in normally sterile sites.
    • Gram-negative bacteria often produce an exotoxin.
    • An exotoxin can have enterotoxic or cytotoxic properties.

    Clinical Significance

    • Gram-negative bacteria are primarily pathogenic to humans
    • Several species cause different diseases in the human body (meningitis).
    • Different species have different symptoms.
    • Some species are widely distributed in nature.
    • Some organisms are opportunistic pathogens, causing disease in weakened hosts.
    • Most species of gram-negative bacteria can be transmitted by the fecal-oral route.

    Vaccines

    • Conjugate meningococcal vaccine (MCV4) was developed in 2005.
    • MCV4 protects against different serogroups that cause meningitis.

    Other

    • Acinetobacter: a genus of gram-negative coccobacilli; important nosocomial pathogens.
    • Francisella: causes tularemia
    • Yersinia enterocolitica: causes disease characterized by fever and diarrhea.
    • Yersinia pestis: known to cause bubonic plague, rather than an enteric disease.

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    Description

    This quiz covers the characteristics and diseases caused by gram-negative bacteria, including notable examples like Neisseria, Moraxella, and Haemophilus. Test your knowledge on the various infections these bacteria can induce in humans, as well as their morphological classifications. Ideal for students studying microbiology or related fields.

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