GPCR Families and Ligands
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Questions and Answers

What is the characteristic feature of the secretin-like family of GPCRs?

  • Small N-terminal extracellular domain
  • Absence of cysteine-rich region
  • Large N-terminal extracellular domain (correct)
  • Presence of Venus flytrap module

    • What is the function of the Gα subunit in the heterotrimeric G protein complex?

  • GTPase activity (correct)
  • Binding of ligands to GPCRs
  • Activation of downstream signaling molecules
  • Formation of the Venus flytrap module

    • What is the function of the cysteine-rich region in mGlu receptors?

  • Formation of the Venus flytrap module
  • Binding of ligands to GPCRs
  • Transduction of conformational change to the rest of the protein (correct)
  • Activation of downstream signaling molecules

    • What is the characteristic feature of the rhodopsin-like family of GPCRs?

    <p>Diversity of ligands</p> Signup and view all the answers

    What is the function of the Gβ subunit in the heterotrimeric G protein complex?

    <p>Unknown function</p> Signup and view all the answers

    What is the characteristic feature of the Frizzled or adhesion GPCRs?

    <p>Cysteine-rich domain in the N-terminus that binds lipoglycoproteins of the Wnt family</p> Signup and view all the answers

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