10 Questions
What percentage of marketed drugs target GPCRs?
35-45%
What is the approximate number of putative GPCRs in the human genome?
750
What percentage of GPCR ligands are visual and olfactory?
50%
What percentage of GPCR ligands are classified as orphans?
20%
What percentage of GPCR ligands are proteins?
7%
What is the dominant class of GPCR ligands?
Visual and olfactory
Which type of GPCR ligands is the least well-represented?
Lipids
Approximately what percentage of GPCRs are classified as orphans or have unknown ligands?
20%
What is the significance of GPCRs in the human genome?
They are the largest family of membrane-spanning receptors
What is the significance of GPCRs in the pharmaceutical industry?
They are targets for a large number of marketed drugs
Study Notes
G Protein-Coupled Receptors (GPCRs)
- 35-45% of marketed drugs target GPCRs
- The human genome contains 750 putative GPCRs
Ligands of GPCRs
- 50% of ligands are visual and olfactory
- 7% of ligands are proteins
- 7% of ligands are biogenic amines
- 8% of ligands are peptides
- 7% of ligands are viral, lipids, nucleotides, calcium, and viral
- 20% of ligands are orphans (i.e., their natural ligands are unknown)
Test your knowledge of G Protein-Coupled Receptors (GPCRs) with this quiz! Learn about the human genome's GPCR count, types of ligands, and more. Get ready to dive into the world of biochemistry and pharmacology!
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