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GPCR Basics

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Questions and Answers

What percentage of marketed drugs target GPCRs?

55-65%

25-35%

45-55%

35-45% (correct)

What is the approximate number of putative GPCRs in the human genome?

600

700

750 (correct)

500

What percentage of GPCR ligands are visual and olfactory?

40%

50% (correct)

30%

60%

What percentage of GPCR ligands are classified as orphans?

20% Signup and view all the answers

What percentage of GPCR ligands are proteins?

7% Signup and view all the answers

What is the dominant class of GPCR ligands?

Visual and olfactory Signup and view all the answers

Which type of GPCR ligands is the least well-represented?

Lipids Signup and view all the answers

Approximately what percentage of GPCRs are classified as orphans or have unknown ligands?

20% Signup and view all the answers

What is the significance of GPCRs in the human genome?

They are the largest family of membrane-spanning receptors Signup and view all the answers

What is the significance of GPCRs in the pharmaceutical industry?

They are targets for a large number of marketed drugs Signup and view all the answers

Study Notes

G Protein-Coupled Receptors (GPCRs)

35-45% of marketed drugs target GPCRs
The human genome contains 750 putative GPCRs

Ligands of GPCRs

50% of ligands are visual and olfactory
7% of ligands are proteins
7% of ligands are biogenic amines
8% of ligands are peptides
7% of ligands are viral, lipids, nucleotides, calcium, and viral
20% of ligands are orphans (i.e., their natural ligands are unknown)

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Description

Test your knowledge of G Protein-Coupled Receptors (GPCRs) with this quiz! Learn about the human genome's GPCR count, types of ligands, and more. Get ready to dive into the world of biochemistry and pharmacology!