6 Questions
What hormone is responsible for stimulating LH and FSH secretion from the anterior pituitary?
Gonadotropin-releasing hormone
In anorexia, why is there a decrease in GnRH pulsation?
Low levels of leptin
What is the mechanism behind reduced ovarian hormone production and follicle stimulation in conditions with decreased GnRH pulsation?
Increased LH and FSH secretion
What effect do GnRH receptor agonists like leuprolide have when administered continuously?
Decrease LH and FSH secretion
Which hormones inhibit the secretion of GnRH through negative feedback?
Estrogen, androgen, progesterone
What effect does insulin resistance have in high-BMI females with polycystic ovarian syndrome (PCOS)?
Decreased LH/FSH ratio
Study Notes
Gonadotropin-Releasing Hormone (GnRH)
- Produced by the hypothalamus, stimulating the secretion of LH and FSH from the anterior pituitary
- Regulates the secretion of "gonadotropins" (LH and FSH), which are peptide hormones
Amenorrhea in Anorexia
- Caused by decreased GnRH pulsation due to low leptin levels
- Leptin is required for adequate GnRH pulsation, and its deficiency leads to reduced GnRH pulsation
- Leptin's role in satiety is important, as its deficiency in anorexia leads to hunger and decreased GnRH pulsation
Effects of GnRH Pulsation
- Decreased GnRH pulsation leads to decreased LH and FSH secretion
- Resulting in reduced ovarian hormone production and follicle stimulation
Polycystic Ovarian Syndrome (PCOS)
- Insulin resistance in high-BMI females causes abnormal GnRH pulsation
- Abnormal GnRH pulsation leads to an increased LH/FSH ratio
GnRH Receptor Agonists
- Leuprolide, goserelin, and nafarelin are GnRH receptor agonists
- When administered continuously, they cause desensitization of the GnRH receptor at the anterior pituitary
- Resulting in decreased LH and FSH secretion, despite being pharmacologic agonists
Negative Feedback
- GnRH secretion is inhibited by estrogen, androgen, and progesterone
- This inhibition is a negative feedback mechanism
Learn about the role of gonadotropin-releasing hormone (GnRH) in anorexia, its relationship with leptin levels, and the mechanism for amenorrhea in anorexic patients. Explore how ¯ GnRH pulsation impacts LH and FSH secretion in the body.
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