Gonadotropin-Releasing Hormone in Anorexia
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Questions and Answers

What hormone is responsible for stimulating LH and FSH secretion from the anterior pituitary?

  • Gonadotropin-releasing hormone (correct)
  • Leptin
  • Estrogen
  • Insulin
  • In anorexia, why is there a decrease in GnRH pulsation?

  • Increased levels of progesterone
  • Elevated levels of estrogen
  • High levels of insulin
  • Low levels of leptin (correct)
  • What is the mechanism behind reduced ovarian hormone production and follicle stimulation in conditions with decreased GnRH pulsation?

  • Elevated levels of leptin
  • Normal GnRH pulsation
  • High progesterone levels
  • Increased LH and FSH secretion (correct)
  • What effect do GnRH receptor agonists like leuprolide have when administered continuously?

    <p>Decrease LH and FSH secretion</p> Signup and view all the answers

    Which hormones inhibit the secretion of GnRH through negative feedback?

    <p>Estrogen, androgen, progesterone</p> Signup and view all the answers

    What effect does insulin resistance have in high-BMI females with polycystic ovarian syndrome (PCOS)?

    <p>Decreased LH/FSH ratio</p> Signup and view all the answers

    Study Notes

    Gonadotropin-Releasing Hormone (GnRH)

    • Produced by the hypothalamus, stimulating the secretion of LH and FSH from the anterior pituitary
    • Regulates the secretion of "gonadotropins" (LH and FSH), which are peptide hormones

    Amenorrhea in Anorexia

    • Caused by decreased GnRH pulsation due to low leptin levels
    • Leptin is required for adequate GnRH pulsation, and its deficiency leads to reduced GnRH pulsation
    • Leptin's role in satiety is important, as its deficiency in anorexia leads to hunger and decreased GnRH pulsation

    Effects of GnRH Pulsation

    • Decreased GnRH pulsation leads to decreased LH and FSH secretion
    • Resulting in reduced ovarian hormone production and follicle stimulation

    Polycystic Ovarian Syndrome (PCOS)

    • Insulin resistance in high-BMI females causes abnormal GnRH pulsation
    • Abnormal GnRH pulsation leads to an increased LH/FSH ratio

    GnRH Receptor Agonists

    • Leuprolide, goserelin, and nafarelin are GnRH receptor agonists
    • When administered continuously, they cause desensitization of the GnRH receptor at the anterior pituitary
    • Resulting in decreased LH and FSH secretion, despite being pharmacologic agonists

    Negative Feedback

    • GnRH secretion is inhibited by estrogen, androgen, and progesterone
    • This inhibition is a negative feedback mechanism

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    Description

    Learn about the role of gonadotropin-releasing hormone (GnRH) in anorexia, its relationship with leptin levels, and the mechanism for amenorrhea in anorexic patients. Explore how ¯ GnRH pulsation impacts LH and FSH secretion in the body.

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