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Questions and Answers
What type of group is attached to the sugar moiety in cyanogenic glycosides?
What type of group is attached to the sugar moiety in cyanogenic glycosides?
How are cyanogenic glycosides hydrolyzed during digestion of plant material?
How are cyanogenic glycosides hydrolyzed during digestion of plant material?
What are some examples of cyanogenic glycosides found in cassava?
What are some examples of cyanogenic glycosides found in cassava?
In what way are glycosides used in medicine?
In what way are glycosides used in medicine?
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What is one role of glycoside-linked signal transduction proteins in biological processes?
What is one role of glycoside-linked signal transduction proteins in biological processes?
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How can understanding the properties and functions of glycosides benefit scientific research?
How can understanding the properties and functions of glycosides benefit scientific research?
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What type of bond is formed between a carbohydrate and a non-sugar molecule in glycosides?
What type of bond is formed between a carbohydrate and a non-sugar molecule in glycosides?
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Which type of glycosides are commonly found linked to proteins through O-glycosidic bonds?
Which type of glycosides are commonly found linked to proteins through O-glycosidic bonds?
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How do glycosides improve the bio-distribution and metabolism of hydrophobic metabolites in plants?
How do glycosides improve the bio-distribution and metabolism of hydrophobic metabolites in plants?
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What happens to small metabolites upon glycosylation in terms of molecular weight and melting point?
What happens to small metabolites upon glycosylation in terms of molecular weight and melting point?
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How can glycosylation of harmful molecules potentially aid in defense against parasites?
How can glycosylation of harmful molecules potentially aid in defense against parasites?
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What is the primary function of glycoproteins within cells?
What is the primary function of glycoproteins within cells?
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Study Notes
Glycosides are compounds that contain a carbohydrate molecule, known as a glycone, which is attached to another non-sugar molecule through a glycosidic bond. This bond is formed at the anomeric carbon of the carbohydrate, creating a strong link between the two molecules. Glycosides play important roles in living organisms, from acting as signal transduction proteins to being used as medications.
The most common type of glycosides are glycoproteins, where sugars are linked to a protein by O-glycosidic bonds. These glycoproteins often perform crucial functions within cells and are found in various enzymes and proteins. They can be activated by biological enzymes through hydrolysis, separating the sugar portion and allowing the activated glycoside to bind to specific intracellular targets.
Glycosides are also found in plants, where they serve multiple purposes such as improving the bio-distribution and metabolism of hydrophobic metabolites. Upon glycosylation, these metabolites become more water-soluble, which in turn allows for better transport across cell membranes. The attachment of sugars to small metabolites raises their molecular weight and melting point, providing stability and facilitating the synthesis and storage of precursors of volatile compounds. Glycosylation can also detoxify harmful molecules by generating non-toxic glycosylated forms, which can be re-activated and used as aglycones in defense against parasites.
One example of plant-based glycosides are cyanogenic glycosides, which consist of an α-hydroxynitrile group attached to a sugar moiety, often a D-glucose. Hydrolysis of these glycosides can be mediated by endogenous β-glucosidases or through the gut microbiome during digestion of plant material. Cyanogenic glycosides are widespread in plants, with over 2,500 species identified to contain them. Some examples include linamarin and lotaustralin found in cassava, which, when consumed, can cause severe pathology.
Glycosides are also used in medicine and can be classified in different ways or according to specific categories. For example, some glycosides are involved in intracellular signaling, particularly in depression and suicide. Glycoside-linked signal transduction proteins are crucial in these processes, and the up-regulation of plasticity-related proteins may have a presynaptic facilitatory effect through the activation of these proteins.
In summary, glycosides are a diverse group of compounds that play essential roles in various biological processes. They are essential in living organisms, provide stability and detoxification in plants, and have significant applications in medicine. Understanding their properties and functions can lead to the development of new therapeutic strategies and a deeper understanding of the molecular mechanisms behind important biological processes.
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Description
Explore the role of glycosides in living organisms, plants, and medicine. Learn about the different types of glycosides, their functions, and applications in various biological processes.
