Glycolysis Quiz
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Questions and Answers

Which phase of glycolysis is responsible for the initial investment of ATP?

  • ATP-generating phase
  • Oxidative phase
  • Preparative phase (correct)
  • Anaerobic phase

    • What regulates the rate-limiting step of glycolysis?

  • Fructose 1,6-bisphosphate
  • NAD+ and NADH
  • ATP and AMP (correct)
  • ADP and glucose

    • What is the primary end product of aerobic glycolysis?

  • Lactate
  • Pyruvate (correct)
  • Glucose
  • Acetyl CoA

    • Which transport protein in the liver allows for excess glucose storage?

    <p>GLUT2</p> Signup and view all the answers

    What are the products of the aldolase reaction in glycolysis?

    <p>Glyceraldehyde 3-phosphate and dihydroxyacetone phosphate</p> Signup and view all the answers

    Which enzyme catalyzes the conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate?

    <p>Phosphoglycerate kinase</p> Signup and view all the answers

    When is lactate produced from pyruvate?

    <p>When oxygen is limited</p> Signup and view all the answers

    What happens to pyruvate under aerobic conditions?

    <p>It enters the TCA cycle after conversion to acetyl-CoA</p> Signup and view all the answers

    What differentiates the ATP-generating phase from the preparative phase in glycolysis?

    <p>It produces more ATP than it consumes</p> Signup and view all the answers

    What is the function of GLUT1 in the liver?

    <p>To ensure constant glucose supply</p> Signup and view all the answers

    What is the net ATP production from anaerobic glycolysis per glucose molecule?

    <p>2 ATP</p> Signup and view all the answers

    Which of the following statements is true regarding the reaction catalyzed by enolase?

    <p>It converts 2-phosphoglycerate to phosphoenolpyruvate</p> Signup and view all the answers

    In which scenario might tissue produce large amounts of lactic acid?

    <p>When it is under pathological hypoxia</p> Signup and view all the answers

    What are the total number of reactions that comprise glycolysis?

    <p>10 reactions</p> Signup and view all the answers

    Which molecule acts as a potent activator of pyruvate kinase?

    <p>Fructose 1,6-bisphosphate</p> Signup and view all the answers

    In glycolysis, which step is considered irreversible?

    <p>Formation of pyruvate from PEP</p> Signup and view all the answers

    What is the approximate total ATP yield from one glucose molecule during aerobic glycolysis?

    <p>7 ATP</p> Signup and view all the answers

    In which part of the cell does glycolysis take place?

    <p>Cytosol</p> Signup and view all the answers

    What is the primary role of the pyruvate dehydrogenase complex?

    <p>Joins glycolysis to the TCA cycle by oxidizing pyruvate</p> Signup and view all the answers

    Which of the following substances inhibit the dephosphorylated form of pyruvate dehydrogenase?

    <p>NADH</p> Signup and view all the answers

    What activates pyruvate dehydrogenase kinase?

    <p>Increase in acetyl CoA</p> Signup and view all the answers

    What happens to citrate after its formation from acetyl CoA and oxaloacetate?

    <p>Conversion to isocitrate</p> Signup and view all the answers

    Which of the following statements is true regarding the regulation of the TCA cycle?

    <p>Citrate synthase is inhibited by high levels of citrate</p> Signup and view all the answers

    During the TCA cycle, what does the conversion of alpha-ketoglutarate to succinyl CoA produce?

    <p>One CO2 molecule and one NADH</p> Signup and view all the answers

    What does glucose-6-phosphatase convert glucose-6-phosphate into?

    <p>Glucose and phosphate</p> Signup and view all the answers

    What is the primary effect of glycogen phosphorylase when it is phosphorylated?

    <p>Stimulates glycogen breakdown</p> Signup and view all the answers

    Which molecule is formed from glycerol during gluconeogenesis?

    <p>Dihydroxyacetone phosphate</p> Signup and view all the answers

    Which enzyme is active when glycogen synthase is unphosphorylated?

    <p>Glycogen synthase</p> Signup and view all the answers

    What is produced as an intermediate of glycolysis from glycerol-3-phosphate?

    <p>Dihydroxyacetone phosphate</p> Signup and view all the answers

    Which compound does glucose-6-phosphatase release into the bloodstream?

    <p>Free glucose</p> Signup and view all the answers

    What role does dihydroxyacetone phosphate play in gluconeogenesis?

    <p>It can be converted to G3P.</p> Signup and view all the answers

    What effect does the phosphorylation state have on glycogen synthase?

    <p>It inhibits glycogen synthesis.</p> Signup and view all the answers

    What is the primary effect of the reaction catalyzed by phosphoglucomutase?

    <p>Isomerisation of glucose-6-phosphate to glucose-1-phosphate</p> Signup and view all the answers

    What is a key regulator of pyruvate carboxylase activity?

    <p>Acetyl CoA</p> Signup and view all the answers

    In which metabolic pathway is glycogenin primarily involved?

    <p>Glycogen synthesis</p> Signup and view all the answers

    During the TCA cycle, which molecule is produced when converting malate to oxaloacetate?

    <p>NADH + H+</p> Signup and view all the answers

    Which reaction requires the addition of water in the TCA cycle?

    <p>Fumarate to malate</p> Signup and view all the answers

    What is the role of ATP synthase in cellular respiration?

    <p>Facilitates ATP synthesis from ADP and inorganic phosphate</p> Signup and view all the answers

    Which molecule acts as a coenzyme for pyruvate carboxylase?

    <p>Biotin</p> Signup and view all the answers

    What effect does NADH have on malate dehydrogenase activity within the TCA cycle?

    <p>Inhibits the enzyme</p> Signup and view all the answers

    Which of the following inhibits Complex I in the electron transport chain?

    <p>Rotenone</p> Signup and view all the answers

    What is the main function of ATP-ADP translocase in cellular metabolism?

    <p>Transport ATP out of the matrix and ADP into the matrix</p> Signup and view all the answers

    Which enzyme catalyzes the conversion of glucose-1-phosphate to UDP-glucose?

    <p>UDP-glucose pyrophosphorylase</p> Signup and view all the answers

    What substance is known to uncouple oxidative phosphorylation?

    <p>Dinitrophenol</p> Signup and view all the answers

    Which of the following describes an effect of the reaction catalyzed by succinate thiokinase?

    <p>Produces ATP or GTP</p> Signup and view all the answers

    What is the primary by-product of anaerobic glycolysis?

    <p>Lactic acid</p> Signup and view all the answers

    What is the primary role of glucose-6-phosphate in the regulation of glycogen synthase in the liver?

    <p>It activates glycogen synthase.</p> Signup and view all the answers

    Which enzyme is responsible for adding glucose molecules to the glycogen chain through 1-4 glycosidic bonds?

    <p>Glycogen synthase</p> Signup and view all the answers

    Which of the following molecules act as allosteric inhibitors of glycogen phosphorylase in the liver?

    <p>Glucose-6-phosphate</p> Signup and view all the answers

    What type of bond is formed by the branching enzyme when it joins chains of glucose in glycogen synthesis?

    <p>1-6 glycosidic bond</p> Signup and view all the answers

    Which coenzyme is critical for the function of glycogen phosphorylase?

    <p>Pyridoxal phosphate</p> Signup and view all the answers

    How does insulin affect glycogen metabolism in the liver?

    <p>It upregulates glycogen synthesis.</p> Signup and view all the answers

    Which of the following hormones downregulates glycogen synthase activity in the liver?

    <p>Glucagon</p> Signup and view all the answers

    The debranching enzyme is crucial for which process in glycogen metabolism?

    <p>Removing branches and facilitating glycogenolysis</p> Signup and view all the answers

    What is the product of the reaction catalyzed by glycogen phosphorylase?

    <p>Glucose-1-phosphate</p> Signup and view all the answers

    How does ATP impact glycogen phosphorylase activity in muscle tissue?

    <p>It inhibits glycogen phosphorylase.</p> Signup and view all the answers

    What triggers the activation of the branching enzyme during glycogen synthesis?

    <p>Insulin signaling</p> Signup and view all the answers

    Which process involves the elongation of the glycogen chain during glycogen synthesis?

    <p>Glycogenesis</p> Signup and view all the answers

    What is the role of the enzyme that catalyzes the conversion of glycogen to glucose-1-phosphate?

    <p>Glycogen degradation</p> Signup and view all the answers

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    Description

    Test your knowledge on the glycolysis pathway with this quiz. Explore key concepts such as ATP investment, regulation, and product formation. Perfect for students studying biochemistry or related fields.

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