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WK 9: Glycolysis
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WK 9: Glycolysis

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Questions and Answers

What is the end product of glycolysis?

  • AcetylCoA
  • Glucose
  • NADH
  • Pyruvate (correct)
  • Which process regenerates NAD+ in anaerobic conditions?

  • Glycogenesis
  • Oxidative phosphorylation
  • Cori Cycle (correct)
  • Krebs Cycle
  • What is the purpose of the Cori Cycle during exercise?

  • To release carbon dioxide
  • To increase oxygen intake
  • To convert lactate into glucose (correct)
  • To produce energy in the form of ATP
  • Which molecule is NOT directly involved in the Krebs Cycle?

    <p>Lactate</p> Signup and view all the answers

    What is the net loss of ATP in the Cori Cycle if you include the ATP made in glycolysis?

    <p>4 ATP</p> Signup and view all the answers

    Which metabolic pathway converts glucose to glycogen for storage?

    <p>Glycogenesis</p> Signup and view all the answers

    Which metabolic pathway describes the conversion of lactate produced by anaerobic glycolysis in muscles to glucose in the liver?

    <p>Cori cycle</p> Signup and view all the answers

    In anaerobic conditions, what is the fate of pyruvate in red blood cells?

    <p>Converted to lactate</p> Signup and view all the answers

    Which process makes NADH available for further ATP production in glycolysis in red blood cells?

    <p>Conversion of lactate to pyruvate</p> Signup and view all the answers

    What is the primary energy production pathway for red blood cells under normal conditions?

    <p>Glycolysis</p> Signup and view all the answers

    In the Cori cycle, what role does the liver play in glucose metabolism?

    <p>Converts lactate to glucose</p> Signup and view all the answers

    What is the key process that allows red blood cells to produce ATP in the absence of oxygen?

    <p>Lactate dehydrogenase reaction</p> Signup and view all the answers

    What is the significance of branching in glycogen synthesis?

    <p>It allows for multiple points of access to glucose molecules.</p> Signup and view all the answers

    During which conditions is glycogenesis activated?

    <p>When insulin signals excess glucose</p> Signup and view all the answers

    What is the role of glycogenin in glycogenesis?

    <p>It is a core protein surrounded by branches of glucose units</p> Signup and view all the answers

    What is the byproduct of glycolysis that is used in glycogenesis?

    <p>Glucose-6-phosphate</p> Signup and view all the answers

    What is the purpose of glycogen storage?

    <p>To store glucose safely as glycogen</p> Signup and view all the answers

    In which cells does glycogenesis occur?

    <p>Muscle cells and liver</p> Signup and view all the answers

    During which process is lactate converted back to glucose in the liver?

    <p>Gluconeogenesis</p> Signup and view all the answers

    What is the primary purpose of converting pyruvate into lactate in the cell?

    <p>Regenerate NAD+</p> Signup and view all the answers

    In which cells does the process of turning glucose into lactate primarily occur?

    <p>All cells</p> Signup and view all the answers

    Which of the following statements best describes the role of glycolysis in cellular metabolism?

    <p>Either in the absence or presence of oxygen</p> Signup and view all the answers

    What happens to the excess lactate produced in patients with renal failure, according to the text?

    <p>Excreted by the kidneys</p> Signup and view all the answers

    How many net ATP are lost in the Cori Cycle before the carbon chain enters regular aerobic metabolism?

    <p>8 ATP</p> Signup and view all the answers

    What is the first step in converting glucose into energy?

    <p>Glycolysis</p> Signup and view all the answers

    Which process maximizes the energy potential of glucose during anaerobic conditions?

    <p>Glycolysis</p> Signup and view all the answers

    What describes the storage and release of glucose in the body?

    <p>Glycogenesis and glycogenolysis</p> Signup and view all the answers

    Which enzyme traps glucose inside the cell via phosphorylation?

    <p>Hexokinase</p> Signup and view all the answers

    What molecule regulates the entry of glucose into the cell?

    <p>Insulin</p> Signup and view all the answers

    What process involves the reduction of NAD+ to NADH?

    <p>Krebs cycle</p> Signup and view all the answers

    Study Notes

    Glycolysis and the Cori Cycle

    • Lactate is produced to allow muscle cells to access NAD+ and continue glycolysis to provide ATP.
    • The Cori Cycle ensures that ATP-rich glucose is not lost as a waste product (lactate) but can be recycled for use by the muscle in aerobic metabolism.
    • The Cori Cycle shows a net loss of 8 ATP, but a net gain once the carbon chain leaves the Cori Cycle and enters into regular aerobic metabolism.

    Lactate and Glucose

    • Lactate is produced in anaerobic conditions, such as in exercising muscle and red blood cells, to regenerate NAD+ for further ATP production in glycolysis.
    • The Cori Cycle transports lactate from muscles to the liver, where it is converted back to glucose through gluconeogenesis.
    • Glucose can be stored as glycogen during glycogenesis and broken down into glucose when needed by muscles or for release into the blood stream.

    Regulation of Glycolysis

    • ATP is made in small quantities, and glucose is stored as glycogen.
    • Fatty acids are stored as triglycerides, and amino acids are used to make proteins.
    • High glucose levels react with protein, requiring safe storage.
    • Glycogenesis is activated during rest and when insulin signals excess glucose.

    Glycogenesis

    • Glycogenesis stores glucose by creating glycogen in muscle cells and the liver.
    • A core protein of glycogenin is surrounded by branches of glucose units.
    • Glycogen synthase and glycogen branching enzyme are involved in the process.
    • Branching allows multiple points of access to glucose molecules.

    Cellular Metabolism

    • Glycolysis is the first step in converting glucose to energy.
    • The Cori Cycle maximizes energy potential in anaerobic conditions.
    • Glycogenesis and glycogenolysis describe glucose storage and release in the body.
    • The Krebs cycle and electron transport chain continue the conversion of glucose into energy.

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    Description

    Explore the processes of glycolysis, Cori cycle, glycogenesis, glycogenolysis, Krebs cycle, and cellular metabolism. Understand how glucose is converted into ATP to power our cells, and how energy potential is maximized under anaerobic conditions.

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