Glucose Stimulation of Insulin Secretion
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Questions and Answers

Which hormone is primarily responsible for maintaining blood glucose levels during fasting?

  • Glucagon (correct)
  • Insulin
  • Epinephrine
  • Cortisol

What is the main physiological role of glucagon in glucose homeostasis?

  • Stimulating insulin secretion
  • Promoting glycogenesis in the liver
  • Increasing blood glucose levels (correct)
  • Inhibiting glucose uptake in peripheral tissues

Which of the following hormones is considered an 'anti-insulin' hormone and acts to increase blood glucose levels?

  • Insulin
  • Glucocorticoids
  • Growth hormone
  • All of the above (correct)

What is the primary function of the liver enzyme glucokinase?

<p>To efficiently phosphorylate glucose when levels are high (A)</p> Signup and view all the answers

Which of the following is a key mechanism by which glucagon maintains blood glucose levels during fasting?

<p>Stimulating gluconeogenesis in the liver (B)</p> Signup and view all the answers

What is the primary metabolic state in which glucagon secretion is increased?

<p>During fasting (D)</p> Signup and view all the answers

Which hormone is secreted by the pancreatic beta cells in response to high blood glucose levels, stimulating glucose uptake by skeletal muscle?

<p>Insulin (C)</p> Signup and view all the answers

Which hormone secreted by the gut in response to a meal decreases glucagon secretion and inhibits gastric emptying?

<p>Glucagon-like peptide 1 (GLP-1) (C)</p> Signup and view all the answers

Which enzyme rapidly inactivates the incretin hormones GLP-1 and GIP?

<p>Dipeptidyl peptidase-4 (DPP-4) (C)</p> Signup and view all the answers

What is the primary function of the hormone amylin, which is secreted by the pancreatic beta cells?

<p>Induce a feeling of satiety and decrease appetite (B)</p> Signup and view all the answers

Which hormone secreted by the pancreatic alpha cells plays a key role in increasing blood glucose levels?

<p>Glucagon (C)</p> Signup and view all the answers

At what approximate blood glucose level does glucose stimulate insulin secretion from the pancreatic beta cells?

<p>$&gt; 70$ mg/dL (B)</p> Signup and view all the answers

Which of the following is the rate-limiting step that controls glucose-regulated insulin secretion?

<p>Glucose phosphorylation by glucokinase (D)</p> Signup and view all the answers

What is the primary mechanism by which glucose stimulates insulin secretion in β-cells?

<p>Inhibition of the ATP-sensitive K+ channel, leading to membrane depolarization and calcium influx (A)</p> Signup and view all the answers

Which of the following is NOT a component of the ATP-sensitive K+ channel in β-cells?

<p>A binding site for incretin hormones like GLP-1 (D)</p> Signup and view all the answers

What is the primary function of incretin hormones, such as GLP-1, in relation to insulin and glucagon secretion?

<p>Stimulate insulin secretion and decrease glucagon secretion (B)</p> Signup and view all the answers

What is the fate of insulin after it is secreted into the portal venous system?

<p>Approximately 50% of the insulin is degraded by the liver (C)</p> Signup and view all the answers

Which of the following is NOT a consequence of insulin binding to its receptor in target tissues?

<p>Inhibition of glycogen synthesis (C)</p> Signup and view all the answers

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