29 Questions
Which enzyme is responsible for bypassing the irreversible hexokinase reaction during glucose 6-phosphate hydrolysis?
Glucose 6-phosphatase
Which two organs release free glucose from G-6-P?
Liver and kidney
What is the function of glucose 6-phosphate translocase?
To transport G-6-P across the ER membrane
Which enzyme is required for the final step of glycogen degradation?
Glycogen phosphorylase
What is Type Ia glycogen storage disease?
Lack of glucose 6-phosphatase
What is the function of glucose 6-phosphate?
To bypass hexokinase reaction
Which two proteins are required for glucose 6-phosphate hydrolysis?
Glucose 6-phosphate translocase and glucose 6-phosphatase
Which cells contain glucose 6-phosphatase?
Gluconeogenic cells
What is the consequence of lack of glucose 6-phosphatase?
Severe fasting hypoglycemia
Which enzyme is responsible for bypassing the irreversible hexokinase reaction during glucose 6-phosphate hydrolysis?
Glucose 6-phosphatase
Which two organs release free glucose from G-6-P?
Liver and kidney
What is the function of glucose 6-phosphate translocase?
To transport G-6-P across the ER membrane
Which enzyme is required for the final step of glycogen degradation?
Glycogen phosphorylase
What is Type Ia glycogen storage disease?
Lack of glucose 6-phosphatase
What is the function of glucose 6-phosphate?
To bypass hexokinase reaction
Which two proteins are required for glucose 6-phosphate hydrolysis?
Glucose 6-phosphate translocase and glucose 6-phosphatase
Which cells contain glucose 6-phosphatase?
Gluconeogenic cells
What is the consequence of lack of glucose 6-phosphatase?
Severe fasting hypoglycemia
Which step of glycogen degradation is glucose 6-phosphate involved in?
None of the above
Which enzyme is responsible for releasing free glucose from G-6-P in liver and kidney?
Glucose 6-phosphatase
Which two proteins are required for transporting G-6-P across the ER membrane and releasing free glucose in liver and kidney?
Glucose 6-phosphate translocase and glucose 6-phosphatase
Which organs in the body release free glucose from G-6-P?
Liver and kidney
What is the consequence of lack of glucose 6-phosphatase in Type Ia glycogen storage disease?
Low blood glucose levels
Which step of glycogen degradation requires glucose 6-phosphate translocase and glucose 6-phosphatase?
Termination of glycogenolysis
Which reaction is bypassed by hydrolysis of glucose 6-phosphate by glucose 6-phosphatase?
Glycogen synthesis
Which two organs in the body have glucose 6-phosphatase?
Liver and kidney
What is Type Ia glycogen storage disease?
A disease caused by lack of glucose 6-phosphatase
Which enzyme is responsible for the first step in glycogen synthesis?
Hexokinase
Which two proteins are required for the final step of glycogen degradation?
Glucose 6-phosphate translocase and glucose 6-phosphatase
Study Notes
Glucose 6-Phosphate Hydrolysis
- Glucose 6-phosphatase is the enzyme responsible for bypassing the irreversible hexokinase reaction during glucose 6-phosphate hydrolysis.
- Liver and kidney are the two organs that release free glucose from G-6-P.
- Glucose 6-phosphate translocase functions in transporting G-6-P across the ER membrane.
Glycogen Degradation
- Glucose 6-phosphatase is required for the final step of glycogen degradation.
- Glucose 6-phosphate translocase and glucose 6-phosphatase are needed for the final step of glycogen degradation.
Glycogen Storage Disease
- Type Ia glycogen storage disease is a disease caused by the lack of glucose 6-phosphatase.
- Consequences of lack of glucose 6-phosphatase include Type Ia glycogen storage disease.
Glucose 6-Phosphate Function
- Glucose 6-phosphate is involved in the step of glycogen degradation that releases free glucose.
- The function of glucose 6-phosphate is to release free glucose from G-6-P.
Proteins Required for Glucose 6-Phosphate Hydrolysis
- Glucose 6-phosphatase and glucose 6-phosphate translocase are the two proteins required for glucose 6-phosphate hydrolysis.
- Glucose 6-phosphatase and glucose 6-phosphate translocase are required for transporting G-6-P across the ER membrane and releasing free glucose in liver and kidney.
Cellular Location of Glucose 6-Phosphatase
- Glucose 6-phosphatase is found in liver and kidney cells.
Enzyme Function in Glycogen Synthesis
- Glucose 6-phosphate is not involved in glycogen synthesis, and the enzyme required for the first step in glycogen synthesis is not glucose 6-phosphatase.
Test your knowledge on glucose metabolism with this quiz! Learn about the hydrolysis of glucose 6-phosphate and the role of glucose 6-phosphatase in bypassing the irreversible hexokinase reaction. Discover which organs release free glucose from G-6-P and the proteins required for this process. Challenge yourself with these fascinating facts about glucose metabolism!
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