Gluconeogensis, glycogenolysis and glycogenesis
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Questions and Answers

Which enzyme is responsible for the conversion of glycerol into dihydroxyacetone phosphate?

  • Debranching enzyme
  • Phosphoglucomutase (correct)
  • Glycogen phosphorylase
  • Glucose-6-phosphatase

What type of bond does glycogen primarily consist of in its structure?

  • Beta 1,4 glycosidic bond
  • Alpha 1,4 glycosidic bond (correct)
  • Hydrogen bond
  • Ester bond

Which enzyme is involved in transferring glucose residues from an a-1,6 linkage to a-1,4 linkage in glycogen?

  • Debranching enzyme (correct)
  • Phosphoglucomutase
  • Glycogen phosphorylase
  • Glucose-6-phosphatase

Which enzyme is essential for the conversion of glucose 6-phosphate into glucose?

<p>Glucose-6-phosphatase (B)</p> Signup and view all the answers

In glycogenolysis, what is the role of glycogen phosphorylase?

<p>Breakdown of glycogen by cleaving its structure (D)</p> Signup and view all the answers

Which process involves the conversion of glucose 1-phosphate to glucose 6-phosphate for further metabolism?

<p>Debranching of glycogen (D)</p> Signup and view all the answers

What enzyme is responsible for cleaving the 1,6-glycosidic bond present in glycogen structure?

<p>Debranching enzyme (D)</p> Signup and view all the answers

Which enzyme plays a critical role in the events of glycogenolysis?

<p>Glycogen phosphorylase (B)</p> Signup and view all the answers

What is the primary function of fructose 2,6-bisphosphate in the context of glycolysis and gluconeogenesis?

<p>Inhibits glycolysis and activates gluconeogenesis (D)</p> Signup and view all the answers

How does insulin affect the formation of fructose 2,6-bisphosphate?

<p>Stimulates the formation of fructose 2,6-bisphosphate (B)</p> Signup and view all the answers

Which enzyme is activated by fructose 2,6-bisphosphate in glycolysis?

<p>Phosphofructokinase 1 (D)</p> Signup and view all the answers

How does glucagon affect the formation of fructose 2,6-bisphosphate?

<p>Decreases the formation of fructose 2,6-bisphosphate (B)</p> Signup and view all the answers

Which process does Fructose 1,6-bisphosphatase stimulate?

<p>Gluconeogenesis (C)</p> Signup and view all the answers

What is the primary function of the Cori cycle?

<p>Clears lactate by converting it back to glucose (B)</p> Signup and view all the answers

In the glucose alanine cycle, what happens to glucose in muscle tissues?

<p>Metabolizes to produce pyruvate (B)</p> Signup and view all the answers

Which molecule can be stored as glycogen or return to muscle tissue according to the text?

<p>Glucose (A)</p> Signup and view all the answers

What is the primary function of gluconeogenesis?

<p>Synthesize glucose from non-carbohydrate precursors (C)</p> Signup and view all the answers

Which of the following is a source of pyruvate in gluconeogenesis?

<p>Alanine (D)</p> Signup and view all the answers

In which organelle does the formation of oxaloacetate take place?

<p>Mitochondria (C)</p> Signup and view all the answers

What is the role of ATP in the formation of oxaloacetate?

<p>Provides energy for the reaction (A)</p> Signup and view all the answers

What is the purpose of converting oxaloacetate into malate in the mitochondria?

<p>To transport oxaloacetate out of the mitochondria (C)</p> Signup and view all the answers

What is the role of phosphoenolpyruvate carboxykinase in gluconeogenesis?

<p>Converts oxaloacetate into phosphoenolpyruvate (D)</p> Signup and view all the answers

What is the final step of gluconeogenesis?

<p>Conversion of glucose 6-phosphate into glucose (D)</p> Signup and view all the answers

Where is the enzyme glucose 6-phosphatase located?

<p>Endoplasmic reticulum (C)</p> Signup and view all the answers

What prevents the conversion of glucose 6-phosphate into glucose in muscle tissue?

<p>Absence of glucose-6-phosphatase (A)</p> Signup and view all the answers

Which hormone is released from adrenal glands during the 'flight or fight' response?

<p>Epinephrine (C)</p> Signup and view all the answers

What is the role of Ca2+ in muscle tissue with respect to glycogenolysis?

<p>Activates glycogenolysis (A)</p> Signup and view all the answers

What is the role of insulin in the regulation of glycogen synthase?

<p>Activates glycogen synthase (C)</p> Signup and view all the answers

Which hormone triggers the conversion of phosphorylase b to phosphorylase a?

<p>Epinephrine (A)</p> Signup and view all the answers

What is the role of the delta subunit of phosphorylase kinase in muscle tissue?

<p>Regulates glycogenolysis (D)</p> Signup and view all the answers

Which process involves the conversion of lactate to pyruvate?

<p>Gluconeogenesis (A)</p> Signup and view all the answers

What is the role of glucagon in the regulation of glycogenolysis?

<p>Activates glycogenolysis (D)</p> Signup and view all the answers

In gluconeogenesis, which enzyme is responsible for the conversion of pyruvate to oxaloacetate?

<p>Pyruvate carboxylase (D)</p> Signup and view all the answers

Which of the following is NOT an inhibitor of phosphofructokinase?

<p>Fructose 2,6-bisphosphate (D)</p> Signup and view all the answers

What is the net effect when glycolysis and gluconeogenesis occur simultaneously in the liver?

<p>ATP hydrolysis (D)</p> Signup and view all the answers

Which of the following stimulates the conversion of fructose 6-phosphate to fructose 2,6-bisphosphate?

<p>None of the above (D)</p> Signup and view all the answers

What is the function of glucose 6-phosphatase in gluconeogenesis?

<p>to convert glucose 6-phosphate to glucose (C)</p> Signup and view all the answers

What is the effect of glucagon on glycolysis?

<p>inhibition (B)</p> Signup and view all the answers

Which of the following is NOT a regulator of gluconeogenesis?

<p>Citrate (B)</p> Signup and view all the answers

What is the function of phosphoenolpyruvate carboxykinase in gluconeogenesis?

<p>to convert oxaloacetate to phosphoenolpyruvate (D)</p> Signup and view all the answers

What enzyme is responsible for the breaking down of glycogen?

<p>Glycogen phosphorylase</p> Signup and view all the answers

What is the main source of glucose for the Cori cycle?

<p>Lactate</p> Signup and view all the answers

What is the primary function of the glucose alanine cycle?

<p>To transport pyruvate from muscle tissues to the liver for gluconeogenesis</p> Signup and view all the answers

Which enzyme is essential for the generation of glucose from glycerol?

<p>Glycerol kinase</p> Signup and view all the answers

How is phosphorylase b converted into the active form phosphorylase a?

<p>Hormones trigger the conversion by stimulating the release of phosphate groups</p> Signup and view all the answers

What is the role of calmodulin in muscle glycogen breakdown?

<p>Calmodulin is the delta subunit of glycogen phosphorylase kinase that activates the enzyme in response to calcium ions</p> Signup and view all the answers

How does insulin contribute to glycogen synthesis?

<p>Insulin promotes glycogen synthesis by activating protein phosphatase 1 to convert active glycogen synthase to an inactive form</p> Signup and view all the answers

What is the conversion process of glucose to glucose 6-phosphate in glycogenesis?

<p>Glucose is converted to glucose 6-phosphate by hexokinase</p> Signup and view all the answers

Which hormone triggers the activation of glycogen phosphorylase for glycogen breakdown?

<p>Epinephrine</p> Signup and view all the answers

What hormone stimulates the release of glucose into the blood by promoting glycogen breakdown in the liver?

<p>Glucagon</p> Signup and view all the answers

Glycerol is converted into glucose 6-phosphate without the formation of dihydroxyacetone phosphate.

<p>False (B)</p> Signup and view all the answers

Glycogen is a linear chain of glucose molecules.

<p>False (B)</p> Signup and view all the answers

Glucose 1-phosphate can be directly converted into glucose 6-phosphate by glycogen phosphorylase.

<p>False (B)</p> Signup and view all the answers

The Cori cycle is a process that involves the conversion of lactate to pyruvate.

<p>False (B)</p> Signup and view all the answers

Gluconeogenesis is the process of generating glucose from non-carbohydrate sources such as glycerol and amino acids.

<p>True (A)</p> Signup and view all the answers

In gluconeogenesis, the formation of oxaloacetate occurs in the cytoplasm.

<p>False (B)</p> Signup and view all the answers

The enzyme glucose 6-phosphatase is present in the mitochondria.

<p>False (B)</p> Signup and view all the answers

Gluconeogenesis occurs only in the liver.

<p>False (B)</p> Signup and view all the answers

Phosphoenolpyruvate carboxykinase is responsible for the formation of malate and mitochondrial exit.

<p>False (B)</p> Signup and view all the answers

Gluconeogenesis is the process of breaking down glycogen to glucose.

<p>False (B)</p> Signup and view all the answers

Muscle cells can directly convert glucose 6-phosphate back into glucose.

<p>False (B)</p> Signup and view all the answers

Glycogen synthase is activated by phosphorylation.

<p>False (B)</p> Signup and view all the answers

Glucagon stimulates glycogen synthesis in the liver.

<p>False (B)</p> Signup and view all the answers

Lactate is a direct precursor of glucose in gluconeogenesis.

<p>True (A)</p> Signup and view all the answers

The Cori cycle involves the conversion of lactate from muscle tissue to glucose in the liver.

<p>True (A)</p> Signup and view all the answers

Flashcards

Glycerol to DHAP enzyme

The enzyme that converts glycerol into dihydroxyacetone phosphate

Glycogen bond type

Alpha-1,4 glycosidic bonds are the main bonds in glycogen structure

Debranching enzyme function

Transfers glucose residues from an a-1,6 linkage to an a-1,4 linkage in glycogen

Glucose 6-phosphate to glucose enzyme

Glucose-6-phosphatase is the enzyme that converts glucose 6-phosphate into glucose

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Glycogen phosphorylase role

Breaks down glycogen by cleaving its structure in glycogenolysis

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Glucose 1-phosphate to glucose 6-phosphate

Process converting glucose 1-phosphate to glucose 6-phosphate for further metabolism

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Fructose 2,6-bisphosphate function

In glycolysis, it inhibits glycolysis and activates gluconeogenesis

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Insulin's effect on F2,6BP

Stimulates the formation of fructose 2,6-bisphosphate

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PFK-1 activator

Fructose 2,6-bisphosphate activates phosphofructokinase 1 (PFK-1)

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Glucagon's effect on F2,6BP

Decreases the formation of fructose 2,6-bisphosphate

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Fructose 1,6-bisphosphatase function

Stimulates gluconeogenesis

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Cori cycle function

Clears lactate by converting it back to glucose

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Glucose alanine cycle - muscle glucose

Muscle glucose is metabolized to produce pyruvate

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Stored molecule in glycogenolysis

Glucose can be stored as glycogen or return to muscle tissue

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Gluconeogenesis function

Synthesizes glucose from non-carbohydrate precursors

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Gluconeogenesis pyruvate source

Alanine is a source of pyruvate in gluconeogenesis

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Oxaloacetate formation location

Oxaloacetate formation occurs in mitochondria

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Oxaloacetate ATP role

ATP provides energy for oxaloacetate formation

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Oxaloacetate to malate role

Oxaloacetate is converted to malate to transport it out of the mitochondria

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PEPCK Role

Converts oxaloacetate to phosphoenolpyruvate in gluconeogenesis

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Gluconeogenesis final step

Conversion of glucose 6-phosphate to glucose

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Glucose 6-phosphatase location

Glucose 6-phosphatase is located in the endoplasmic reticulum

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Muscle glucose 6-phosphatase issue

Muscle tissue lacks glucose-6-phosphatase, preventing conversion of glucose 6-phosphate to glucose

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