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Glucokinase Roles in Liver and Pancreatic Cells

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Glucokinase Roles in Liver and Pancreatic Cells

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Questions and Answers

Which molecule makes PFK activity more responsive to substrate?

F-2,6-BP (correct)
ATP
AMP
ADP

Which enzyme catalyzes an irreversible step in the glycolytic pathway with no meaningful back-reaction?

FBPase
Aldolase
Enzyme f
PFK (correct)

What effect does F-2,6-BP have on PFK activity in relation to ATP and FBPase?

Decreases the inhibitory effects of ATP and stimulates FBPase activity
Decreases the inhibitory effects of ATP and opposes FBPase activity (correct)
Increases the inhibitory effects of ATP and stimulates FBPase activity
Opposes the inhibitory effects of ATP and stimulates FBPase activity

What role does substrate cycling play in the glycolytic pathway?

It enhances the regulation of enzyme activities (D) Signup and view all the answers

Which molecules act as 'brakes' in regulating enzyme activities within the glycolytic pathway?

ADP and AMP (C) Signup and view all the answers

What type of regulation is described when enzymes within the glycolytic pathway are allosterically regulated by effectors like gas and brake pedals?

Allosteric regulation (A) Signup and view all the answers

What is the role of F-2,6-BP in the regulation of PFK?

Activates PFK (C) Signup and view all the answers

How does ATP affect PFK regulation?

Inhibits PFK (B) Signup and view all the answers

What is the main function of substrate cycling in glycolysis?

To maintain metabolic balance (A) Signup and view all the answers

How is FBPase regulated in the glycolytic pathway?

Inhibition by ATP (C) Signup and view all the answers

Which statement best describes enzyme allosteric regulation?

It can occur even with high substrate concentrations (D) Signup and view all the answers

How does AMP affect enzyme activity in the glycolytic pathway?

Activates enzyme activity (A) Signup and view all the answers

What is the major rate-determining step in glycolysis?

Conversion of F6P to FBP by PFK (B) Signup and view all the answers

What inhibits phosphofructokinase (PFK) activity, indicating high energy levels in the cell?

ATP (A) Signup and view all the answers

What is the regulatory molecule that stimulates phosphofructokinase (PFK) activity?

AMP (B) Signup and view all the answers

Which statement describes the allosteric regulation of PFK accurately?

ATP inhibits PFK by binding to the regulatory site, promoting the R state. (C) Signup and view all the answers

What is the role of fructose-2,6-bisphosphate in regulating phosphofructokinase (PFK)?

It enhances PFK activity by acting as an allosteric activator. (A) Signup and view all the answers

Which molecule has the highest potential to stimulate a significant increase in phosphofructokinase (PFK) activity?

$102$-fold increase in ATP levels (B) Signup and view all the answers