10 Questions
Where is the glucagon receptor predominantly expressed?
Kidneys
What is another name for the glucagon receptor due to its structure?
Serpentine receptor
What happens when glucagon binds to the glucagon receptor?
It stimulates a classic G-protein
Which nucleotide is displaced by GTP in the alpha subunit of the G-protein upon activation?
GDP
What is converted into cAMP when Adenylyl cyclase is activated?
ATP
What is the role of protein-kinase A in the signaling pathway?
Activates transcription factors through phosphorylation
Which downstream signaling protein is activated by GQ, another type of G-protein?
Phospholipase-C
What does G small 'i' do when activated?
Inhibits Adenylyl cyclase
'KREB' binds to response elements of target-genes through what process?
'KREB' phosphorylation
'CRE'-cAMP response elements binding protein is involved in what biological process?
'CREB' binding to DNA for gene expression regulation
Test your knowledge on the effects of glucagon mediated through binding to and activation of the glucagon receptor, predominantly expressed in various organs. Explore the functions of the seven transmembrane G protein-coupled receptor also known as 'serpentine receptor'.
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