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Questions and Answers
What is the primary function of oxygen transport systems in large animals?
What is the primary function of oxygen transport systems in large animals?
- To allow for the transport of dissolved gas alone
- To enable the circulation of respiratory molecules
- To facilitate the pickup and release of oxygen at different locations (correct)
- To provide respiratory molecules and cells for transport and storage
What is the key prosthetic group that allows globin proteins to bind oxygen?
What is the key prosthetic group that allows globin proteins to bind oxygen?
- The distal histidine residue
- The ferrous (Fe2+) oxidation state of the iron atom
- The porphyrin ring with a central metal atom (correct)
- The proximal histidine residue
How does the iron atom in the heme group interact with oxygen?
How does the iron atom in the heme group interact with oxygen?
- The iron atom temporarily accepts an electron from oxygen, forming a superoxide radical (correct)
- The iron atom is oxidized to the ferric (Fe3+) state, which prevents oxygen binding
- The iron atom binds oxygen directly, forming a stable complex
- The distal histidine residue forms a hydrogen bond with the oxygen molecule
What is the role of the proximal and distal histidine residues in the heme pocket?
What is the role of the proximal and distal histidine residues in the heme pocket?
What is the significance of the Bohr effect in the regulation of hemoglobin?
What is the significance of the Bohr effect in the regulation of hemoglobin?
How does fetal hemoglobin differ from adult hemoglobin in its oxygen-binding properties?
How does fetal hemoglobin differ from adult hemoglobin in its oxygen-binding properties?
What is the role of distal histidine in hemoglobin?
What is the role of distal histidine in hemoglobin?
How does hemoglobin enhance selectivity for oxygen?
How does hemoglobin enhance selectivity for oxygen?
How do myoglobin (Mb) and hemoglobin (Hb) differ?
How do myoglobin (Mb) and hemoglobin (Hb) differ?
What effect does oxygen binding have on the magnetic properties of iron in hemoglobin?
What effect does oxygen binding have on the magnetic properties of iron in hemoglobin?
What happens to the Fe ion when oxygen binds to hemoglobin?
What happens to the Fe ion when oxygen binds to hemoglobin?
In a simple binding reaction, what determines the equilibrium between P + L and PL?
In a simple binding reaction, what determines the equilibrium between P + L and PL?
What structural change occurs in hemoglobin when oxygen binds?
What structural change occurs in hemoglobin when oxygen binds?
Why is the affinity of hemoglobin for oxygen lower in red blood cells compared to in vitro conditions?
Why is the affinity of hemoglobin for oxygen lower in red blood cells compared to in vitro conditions?
What is the primary function of 2,3-bisphosphoglycerate (2,3-BPG) in regulating hemoglobin activity?
What is the primary function of 2,3-bisphosphoglycerate (2,3-BPG) in regulating hemoglobin activity?
How does fetal hemoglobin differ from adult hemoglobin?
How does fetal hemoglobin differ from adult hemoglobin?
What is the significant change in fetal hemoglobin that affects its interaction with 2,3-BPG?
What is the significant change in fetal hemoglobin that affects its interaction with 2,3-BPG?
What is the Bohr effect in relation to hemoglobin?
What is the Bohr effect in relation to hemoglobin?
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