Podcast
Questions and Answers
What are the diagnostic histological features of glioblastoma multiforme?
What are the diagnostic histological features of glioblastoma multiforme?
Marked cellularity, cellular pleomorphism, mitoses, multinucleated tumor giant cells, pseudopalisading necrosis, microvascular proliferation
How does Grade IV Astrocytoma-Glioblastoma multiforme appear grossly?
How does Grade IV Astrocytoma-Glioblastoma multiforme appear grossly?
Soft and yellow or red due to necrosis or hemorrhage, with features like necrosis, hemorrhage, cystic changes
What are the criteria for diagnosing Glioblastoma multiforme?
What are the criteria for diagnosing Glioblastoma multiforme?
At least three out of the four criteria: marked cellularity, cellular pleomorphism, mitoses, multinucleated tumor giant cells
How does Pilocytic astrocytoma (WHO Grade 1) differ from Glioblastoma multiforme in terms of behavior?
How does Pilocytic astrocytoma (WHO Grade 1) differ from Glioblastoma multiforme in terms of behavior?
What is the characteristic feature of Glioblastoma multiforme pseudopalisading necrosis?
What is the characteristic feature of Glioblastoma multiforme pseudopalisading necrosis?
What are the unique characteristics that set CNS tumors apart from neoplastic processes elsewhere in the body?
What are the unique characteristics that set CNS tumors apart from neoplastic processes elsewhere in the body?
What is the common genetic fusion/duplication found in Pilocytic astrocytoma?
What is the common genetic fusion/duplication found in Pilocytic astrocytoma?
What is the key histological feature that defines a Grade IV astrocytoma, also known as glioblastoma multiforme?
What is the key histological feature that defines a Grade IV astrocytoma, also known as glioblastoma multiforme?
What are the key cell types from which primary brain tumors can originate, according to the information provided?
What are the key cell types from which primary brain tumors can originate, according to the information provided?
How do pilocytic astrocytomas differ from glioblastoma multiforme in terms of their biologic behavior and WHO grade?
How do pilocytic astrocytomas differ from glioblastoma multiforme in terms of their biologic behavior and WHO grade?
What are the key criteria that define a glioblastoma multiforme (Grade IV astrocytoma) according to the information provided?
What are the key criteria that define a glioblastoma multiforme (Grade IV astrocytoma) according to the information provided?
What is the most common type of glioma, accounting for 60% of all gliomas?
What is the most common type of glioma, accounting for 60% of all gliomas?
What are the two main genetic subtypes of glioblastoma multiforme based on IDH mutation status?
What are the two main genetic subtypes of glioblastoma multiforme based on IDH mutation status?
What are the four key histological criteria that define a glioblastoma multiforme (Grade IV astrocytoma)?
What are the four key histological criteria that define a glioblastoma multiforme (Grade IV astrocytoma)?
What is the typical age of onset for glioblastoma multiforme?
What is the typical age of onset for glioblastoma multiforme?
What are the two main ways glioblastoma multiforme can present - primary (de novo) and secondary?
What are the two main ways glioblastoma multiforme can present - primary (de novo) and secondary?
What are the typical locations that glioblastoma multiforme occurs in the brain?
What are the typical locations that glioblastoma multiforme occurs in the brain?
What is the prognosis for patients with glioblastoma multiforme?
What is the prognosis for patients with glioblastoma multiforme?
How does a pilocytic astrocytoma (Grade I) differ from a diffuse astrocytoma (Grade II) in terms of histological features and clinical behavior?
How does a pilocytic astrocytoma (Grade I) differ from a diffuse astrocytoma (Grade II) in terms of histological features and clinical behavior?
What are the typical presenting symptoms of glioblastoma multiforme?
What are the typical presenting symptoms of glioblastoma multiforme?
What are the typical MRI findings for a glioblastoma multiforme?
What are the typical MRI findings for a glioblastoma multiforme?