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Questions and Answers
What structural and functional alterations were observed in the GI tract of Abx-treated mice?
What structural and functional alterations were observed in the GI tract of Abx-treated mice?
Adult male and female Abx-treated mice exhibited a longer small intestine, slower transit time, increased carbachol-stimulated ion secretion, and increased intestinal permeability.
What was the impact of Abx treatment on enteric neurons in the ileum and proximal colon?
What was the impact of Abx treatment on enteric neurons in the ileum and proximal colon?
Abx treatment resulted in the loss of enteric neurons in both submucosal and myenteric plexuses in the ileum and proximal colon.
What effect did microbiota recovery have on intestinal function and enteric neurogenesis?
What effect did microbiota recovery have on intestinal function and enteric neurogenesis?
Microbiota recovery restored intestinal function and stimulated enteric neurogenesis, leading to increases in the number of enteric glia and neurons.
What impact did lipopolysaccharide (LPS) supplementation have on neuronal survival?
What impact did lipopolysaccharide (LPS) supplementation have on neuronal survival?
What was the role of short-chain fatty acids (SCFA) in neuronal recovery after Abx-induced neuronal loss?
What was the role of short-chain fatty acids (SCFA) in neuronal recovery after Abx-induced neuronal loss?
What are some of the structural and functional alterations observed in the GI tract of Abx-treated mice?
What are some of the structural and functional alterations observed in the GI tract of Abx-treated mice?
What changes were observed in the enteric neurons in the ileum and proximal colon of Abx-treated mice?
What changes were observed in the enteric neurons in the ileum and proximal colon of Abx-treated mice?
What impact did recovery of the microbiota have on intestinal function and enteric neurogenesis?
What impact did recovery of the microbiota have on intestinal function and enteric neurogenesis?
What effect did lipopolysaccharide (LPS) supplementation have on neuronal survival?
What effect did lipopolysaccharide (LPS) supplementation have on neuronal survival?
How did short-chain fatty acids (SCFA) contribute to neuronal recovery after Abx-induced neuronal loss?
How did short-chain fatty acids (SCFA) contribute to neuronal recovery after Abx-induced neuronal loss?
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Study Notes
Abx-Treated Mice Gut Alterations
- Adult male and female Abx-treated mice exhibit alterations in GI structure and function, including a longer small intestine and slower transit time.
- Abx-treated mice also experience increased carbachol-stimulated ion secretion and increased intestinal permeability.
Neuronal Loss in Abx-Treated Mice
- Loss of enteric neurons in the ileum and proximal colon in both submucosal and myenteric plexuses.
- Reduction in the number of enteric glia only observed in the ileal myenteric plexus.
Recovery of Microbiota and Neurogenesis
- Recovery of the microbiota restores intestinal function and stimulates enteric neurogenesis.
- Enteric neurogenesis leads to increases in the number of enteric glia and neurons.
SCFA and LPS Effects
- Lipopolysaccharide (LPS) supplementation enhances neuronal survival alongside bacterial depletion.
- LPS has no effect on neuronal recovery once Abx-induced neuronal loss is established.
- Short-chain fatty acids (SCFA) restore neuronal numbers after Abx-induced neuronal loss.
- SCFA stimulate enteric neurogenesis in vivo.
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