GI Alterations in Abx-Treated Mice

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Questions and Answers

What structural and functional alterations were observed in the GI tract of Abx-treated mice?

Adult male and female Abx-treated mice exhibited a longer small intestine, slower transit time, increased carbachol-stimulated ion secretion, and increased intestinal permeability.

What was the impact of Abx treatment on enteric neurons in the ileum and proximal colon?

Abx treatment resulted in the loss of enteric neurons in both submucosal and myenteric plexuses in the ileum and proximal colon.

What effect did microbiota recovery have on intestinal function and enteric neurogenesis?

Microbiota recovery restored intestinal function and stimulated enteric neurogenesis, leading to increases in the number of enteric glia and neurons.

What impact did lipopolysaccharide (LPS) supplementation have on neuronal survival?

LPS supplementation enhanced neuronal survival during bacterial depletion, but had no effect on neuronal recovery after Abx-induced neuronal loss was established. Signup and view all the answers

What was the role of short-chain fatty acids (SCFA) in neuronal recovery after Abx-induced neuronal loss?

SCFA were able to restore neuronal numbers after Abx-induced neuronal loss, demonstrating that SCFA stimulate enteric neurogenesis in vivo. Signup and view all the answers

What are some of the structural and functional alterations observed in the GI tract of Abx-treated mice?

Adult male and female Abx-treated mice exhibited alterations in GI structure and function, including a longer small intestine, slower transit time, increased carbachol-stimulated ion secretion, and increased intestinal permeability. Signup and view all the answers

What changes were observed in the enteric neurons in the ileum and proximal colon of Abx-treated mice?

The enteric neurons in the ileum and proximal colon of Abx-treated mice experienced a loss in both submucosal and myenteric plexuses. Signup and view all the answers

What impact did recovery of the microbiota have on intestinal function and enteric neurogenesis?

Recovery of the microbiota restored intestinal function and stimulated enteric neurogenesis. Signup and view all the answers

What effect did lipopolysaccharide (LPS) supplementation have on neuronal survival?

Lipopolysaccharide (LPS) supplementation enhanced neuronal survival alongside bacterial depletion. Signup and view all the answers

How did short-chain fatty acids (SCFA) contribute to neuronal recovery after Abx-induced neuronal loss?

Short-chain fatty acids (SCFA) were able to restore neuronal numbers after Abx-induced neuronal loss, demonstrating that SCFA stimulate enteric neurogenesis in vivo. Signup and view all the answers

Study Notes

Abx-Treated Mice Gut Alterations

Adult male and female Abx-treated mice exhibit alterations in GI structure and function, including a longer small intestine and slower transit time.
Abx-treated mice also experience increased carbachol-stimulated ion secretion and increased intestinal permeability.

Neuronal Loss in Abx-Treated Mice

Loss of enteric neurons in the ileum and proximal colon in both submucosal and myenteric plexuses.
Reduction in the number of enteric glia only observed in the ileal myenteric plexus.

Recovery of Microbiota and Neurogenesis

Recovery of the microbiota restores intestinal function and stimulates enteric neurogenesis.
Enteric neurogenesis leads to increases in the number of enteric glia and neurons.

SCFA and LPS Effects

Lipopolysaccharide (LPS) supplementation enhances neuronal survival alongside bacterial depletion.
LPS has no effect on neuronal recovery once Abx-induced neuronal loss is established.
Short-chain fatty acids (SCFA) restore neuronal numbers after Abx-induced neuronal loss.
SCFA stimulate enteric neurogenesis in vivo.

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Description

Quiz: Test Your Knowledge on GI Alterations in Abx-Treated Mice Challenge yourself with this quiz to assess your understanding of the GI structure and function alterations observed in adult male and female Abx-treated mice. Explore topics such as longer small intestine, slower transit time, increased ion secretion, and intestinal permeability. Also, learn about the loss of enteric neurons and reduction in their numbers.