Definition, evolution, importance and models

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What is the statistical definition of ageing?

The increase in probability of death as you age

What is the biological definition of ageing?

The change in characteristics and progressive impairment as you age

What is programmed ageing theory?

Genes beneficial early, harmful later

Cannot select against harmful mutations as we age

Evolution/natural selection for programmed death (correct)

Maintenance required only till germ-line is passed

What is mutation accumulation theory for ageing?

Cannot select against harmful mutations as we age Signup and view all the answers

Antagonistic Pleiotropy

Genes beneficial early, harmful later on Signup and view all the answers

What is disposable soma theory of ageing?

Maintenance of organism until germ line is passed on Signup and view all the answers

What universal mechanism ONLY decreases lifespan, with the rest increasing, or increasing + decreasing?

Mutations in genomic stability Signup and view all the answers

What is the generation time for budding yeast?

90 minutes Signup and view all the answers

How many daughter cells does yeast create in its' lifespan?

20 Signup and view all the answers

How big is yeast's genome?

12 Mb Signup and view all the answers

What is the lifespan for the nematode worm?

3 weeks Signup and view all the answers

How many cells are in the nematode worm?

959 cells Signup and view all the answers

What is the genome size of the nematode worm?

100 Mb Signup and view all the answers

What is the lifespan of the fruit fly

7 weeks Signup and view all the answers

How big is the fruit fly's genome?

180 Mb Signup and view all the answers

What is the lifespan of the mouse?

1-3 years Signup and view all the answers

What is the genome size of the mouse?

2600 Mb Signup and view all the answers

What was discovered with the budding yeast model?

DR Mechanisms Signup and view all the answers

What was discovered with the nematode worm model?

IIS pathway Signup and view all the answers

What was discovered with the fruit fly model?

DR mechanisms and IIS pathway Signup and view all the answers

What was discovered with the mouse model?

DR Mechanisms, Telomerase/replicative senescence Signup and view all the answers