Germinal Centre Reaction and CD40L:CD40 Interaction in Immunobiology
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Germinal Centre Reaction and CD40L:CD40 Interaction in Immunobiology

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Questions and Answers

What is the main function of centrocytes in the germinal center?

  • Undergo somatic hypermutation
  • Compete for antigen binding strength (correct)
  • Produce antigens
  • Proliferate rapidly

    • Which chemokine is produced by stromal cells in the dark zone of the germinal center?

  • CXCR4
  • CXCR5
  • CXCL13
  • CXCL12 (correct)

    • What is the role of follicular dendritic cells (FDCs) in the germinal center?

  • Retain centrocytes (correct)
  • Produce antibodies
  • Produce chemokine CXCL13
  • Attract CD4 T cells

    • Which cell type is mainly responsible for antigen capture in B cells?

    <p>Macrophages</p> Signup and view all the answers

    What facilitates the activation of B cells in response to protein antigens?

    <p>CD4 T cells</p> Signup and view all the answers

    What occurs in the dark zone of the germinal center?

    <p>Centroblast rapid division</p> Signup and view all the answers

    What is the main function of TFH cells in the immune response?

    <p>Facilitate B cell activation</p> Signup and view all the answers

    Which marker is used for identifying proliferating cells in a germinal center?

    <p>Ki67</p> Signup and view all the answers

    'Somatic hypermutation' primarily occurs in which area of the germinal center?

    <p>'Dark zone'</p> Signup and view all the answers

    What is the role of CXCR5 in relation to germinal centers?

    <p>Attract and retain centrocytes</p> Signup and view all the answers

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