Germinal Centre Reaction and CD40L:CD40 Interaction in Immunobiology
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Germinal Centre Reaction and CD40L:CD40 Interaction in Immunobiology

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Questions and Answers

What is the main function of centrocytes in the germinal center?

Compete for antigen binding strength

Which chemokine is produced by stromal cells in the dark zone of the germinal center?

CXCL12

What is the role of follicular dendritic cells (FDCs) in the germinal center?

Retain centrocytes

Which cell type is mainly responsible for antigen capture in B cells?

<p>Macrophages</p> Signup and view all the answers

What facilitates the activation of B cells in response to protein antigens?

<p>CD4 T cells</p> Signup and view all the answers

What occurs in the dark zone of the germinal center?

<p>Centroblast rapid division</p> Signup and view all the answers

What is the main function of TFH cells in the immune response?

<p>Facilitate B cell activation</p> Signup and view all the answers

Which marker is used for identifying proliferating cells in a germinal center?

<p>Ki67</p> Signup and view all the answers

'Somatic hypermutation' primarily occurs in which area of the germinal center?

<p>'Dark zone'</p> Signup and view all the answers

What is the role of CXCR5 in relation to germinal centers?

<p>Attract and retain centrocytes</p> Signup and view all the answers

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