Questions and Answers
What class of antibiotic is Gentamicin?
What is the preparation form of Gentamicin?
80mg/2ml ampoule
What are the indications for Gentamicin?
Sepsis, if the site of infection is the urinary tract, abdomen, or unknown.
Which of the following are contraindications for using Gentamicin? (Select all that apply)
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What are the cautions for Gentamicin?
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What are the pharmacodynamics of Gentamicin?
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What is the elimination half-life of Gentamicin?
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How is Gentamicin excreted from the body?
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What is the dosage for an 80kg patient taking Gentamicin?
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Study Notes
Gentamicin Overview
- Class: Aminoglycoside antibiotic (AB) utilized primarily in treating various bacterial infections.
Preparation Information
- Available as an 80mg/2ml ampoule for intravenous use.
Clinical Indications
- Indicated for sepsis when combined with Augmentin, effective for urinary tract, abdominal infections, or unknown sites.
- Recommended for patients aged 12 years and older, with specific clinical advice sought if 30 minutes from hospital.
Contraindications
- Severe allergies to Gentamicin are a major contraindication.
- Not to be used during pregnancy due to potential risks.
Cautions
- No specific cautions listed for Gentamicin usage.
Pharmacodynamics Insights
- Acts by irreversibly binding to the 30S ribosomal subunit, halting bacterial protein synthesis crucial for growth.
- Effective against aerobic and gram-negative bacteria; less effective for gram-positive due to toxicity concerns.
- Displaces cations in bacterial biofilm, creating gaps that compromise cell wall integrity leading to bacterial cell death.
Pharmacokinetics Summary
- Absorption & Distribution: Lacks protein binding; plasma levels decrease exponentially due to renal excretion.
- Metabolism: Not metabolized; completely excreted unchanged in urine.
- Excretion: Clearance affected by kidney function, especially in patients with impairment, neonates, and the elderly.
- Elimination Half-Life: Approximately 2.1 hours, indicating rapid clearance from the body.
Dosage Recommendations
- For an 80kg patient, the appropriate dosage is 400mg. Further specifics may be required based on individual patient circumstances.
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Review essential information on Gentamicin with these flashcards. Each card covers important aspects such as class, preparation, indications, and contraindications. Perfect for students and healthcare professionals wanting to enhance their pharmacology knowledge.
