Genetics: Spacer Molecules, Promoters, Telomere, and Centromere
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Questions and Answers

What is the function of a centromere during mitosis and meiosis?

  • Anchors the chromosome to the spindle fibers (correct)
  • Records the number of cell divisions
  • Protects RNA from degradation
  • Contains highly repeated sequences like (TTAGGG)n

Which molecules signal and control transcription in gene sequences?

  • Exons
  • Introns
  • Telomeres
  • Promoters/enhancers (correct)

What is the primary role of the tail added to hnRNA at its 3’-end?

  • Encodes stop codons
  • Initiation of protein synthesis
  • Prevents degradation of RNA (correct)
  • Acts as a spacer in gene sequences

How do exons differ from introns in gene sequences?

<p>Exons separate coding genes, introns loop out prior to protein synthesis (D)</p> Signup and view all the answers

What kind of sequences are found in telomeres that serve as aging markers?

<p>(TTAGGG)n repeats (D)</p> Signup and view all the answers

During hnRNA synthesis, what is the role of the GTP cap added to the 5’-end?

<p>Initiates protein synthesis (D)</p> Signup and view all the answers

What type of proteins aid in looping out the introns during mRNA formation from hnRNA?

<p>Small nuclear proteins (C)</p> Signup and view all the answers

In the context of protein synthesis, what is the role of N,N’-dimethyl guanine in tRNA?

<p>Helps in twisted conformation of tRNA for amino acid transportation (A)</p> Signup and view all the answers

What is the specific function of the acceptor stem in tRNA?

<p>Carrying the amino acid (C)</p> Signup and view all the answers

Which RNA type is directly involved in protein formation from mRNA?

<p><strong>mRNA</strong> (A)</p> Signup and view all the answers

What is the primary function of the anticodon site on tRNA?

<p><strong>Binding to a 3-base codon of mRNA</strong> (A)</p> Signup and view all the answers

Which region of tRNA first binds to its corresponding amino acid before entering the ribosome for protein synthesis?

<p><strong>Acceptor stem (3’ end)</strong> (D)</p> Signup and view all the answers

What is the role of p53, p63, and p73 in inhibiting cyclinD/CDK4 complex?

<p>Cause the synthesis of mRNA for p21, a protein that inhibits cyclinD/CDK4 (A)</p> Signup and view all the answers

How does an defect in p53 affect the cell cycle?

<p>Allows uncontrolled cell division by cyclinD/CDK4 complex (D)</p> Signup and view all the answers

What is the significance of CDK4 in cell cycle progression?

<p>Influences the division ability of cells to enter S phase (C)</p> Signup and view all the answers

What is the primary function of heat shock proteins in an organism?

<p>Solubilizing and refolding any heat-denatured proteins (B)</p> Signup and view all the answers

How do E2F and Rb proteins influence the cell cycle progression?

<p>Facilitate passage from G1 to S phase by binding and releasing each other (C)</p> Signup and view all the answers

What is the number of genes and exons for Alpha-crystallin?

<p>2 genes with 3 exons per gene (A)</p> Signup and view all the answers

What is the role of RNA primase in DNA replication?

<p>Synthesizes short strands of primer RNA (D)</p> Signup and view all the answers

Which enzyme is responsible for completing the gaps between DNA Okazaki fragments?

<p>Ligase enzyme (D)</p> Signup and view all the answers

What is the function of Transfer RNA (tRNA) in protein synthesis?

<p>Attaches to specific amino acids and transports them to ribosomes (D)</p> Signup and view all the answers

What is the primary function of Ribosomal RNA (rRNA) in protein synthesis?

<p>Represents 75% of all RNA in a cell (A)</p> Signup and view all the answers

Which type of RNA represents the most common occurrence and what percentage of RNA does it make up?

<p>Ribosomal RNA (rRNA); 75% (D)</p> Signup and view all the answers

What is the primary role of telomeres in preserving chromosome integrity?

<p>Recording the number of cell divisions as an aging marker (B)</p> Signup and view all the answers

Which of the following is a characteristic of hnRNA?

<p>Looped out of a coding sequence prior to protein synthesis (B)</p> Signup and view all the answers

What is the function of the GTP cap added at the 3’-end of hnRNA before mRNA synthesis?

<p>Protects RNA from degradation (C)</p> Signup and view all the answers

In gene sequences, what differentiates introns from exons?

<p>Exons loop out of coding sequences before protein synthesis, while introns remain intact (D)</p> Signup and view all the answers

What type of sequences are highly repeated in mammalian telomeres?

<p>(TTAGGG)n (C)</p> Signup and view all the answers

What is the role of the GTP cap added to hnRNA at the 5’-end?

<p>Aids in splicing out introns during mRNA formation (C)</p> Signup and view all the answers

What is the significance of CDK4 in the context of protein synthesis?

<p>Regulates cell cycle progression and inhibits protein synthesis (B)</p> Signup and view all the answers

How do E2F and Rb proteins influence mRNA formation from hnRNA?

<p>Regulate transcriptional activation and repression (B)</p> Signup and view all the answers

In the context of genetic code, what is the function of a stop codon?

<p>Signals the termination of protein synthesis (B)</p> Signup and view all the answers

What type of proteins aid in telomere maintenance and serve as aging markers?

<p>Telomerase proteins (C)</p> Signup and view all the answers

What is the specific function of regulatory proteins in hnRNA synthesis?

<p>Inhibiting the initiation of hnRNA synthesis (C)</p> Signup and view all the answers

Where does RNA polymerase bind to initiate transcription?

<p>To the minor groove of DNA (D)</p> Signup and view all the answers

What does a stop code indicate in the genetic code?

<p>The termination of protein synthesis (A)</p> Signup and view all the answers

What are the diverse roles of noncoding regions in DNA?

<p>Contributing to regulation of gene expression and chromatin structure (C)</p> Signup and view all the answers

What kind of sequences are typically found in telomeres and serve as aging markers?

<p>Guanine repeats (D)</p> Signup and view all the answers

What is the catalytic activity responsible for peptide bond formation in the ribosome?

<p>23S rRNA catalytic activity (B)</p> Signup and view all the answers

Which photoproduct is formed when adjacent pyrimidines bond due to UV exposure, distorting the DNA helix?

<p>6-4 photoproduct (A)</p> Signup and view all the answers

What is the primary role of telomeres in a cell's genetic material?

<p>Protect chromosome ends from deterioration and fusion (A)</p> Signup and view all the answers

What is the primary function of regulatory proteins in hnRNA synthesis?

<p>Control initiation and elongation of RNA polymerase (A)</p> Signup and view all the answers

How does the turnover rate of proteins relate to mRNA molecules?

<p>Multiple proteins can be formed from one mRNA molecule (A)</p> Signup and view all the answers

What is the primary function of telomeres?

<p>Prevent degradation and unnecessary recombination of DNA (C)</p> Signup and view all the answers

In hnRNA synthesis, what is the specific role of regulatory proteins?

<p>Protect the newly transcribed RNA molecule from degradation (B)</p> Signup and view all the answers

What is the significance of noncoding DNA regions in the genome?

<p>They regulate gene expression and play a role in cell differentiation (A)</p> Signup and view all the answers

Which statement best describes the genetic code and its relation to stop codons?

<p>Specific sets of 3 bases in the genetic code act as stop codons (A)</p> Signup and view all the answers

During transcription, what is the main role of RNA polymerase regarding binding to DNA?

<p>Recognizes specific promoter sequences to initiate transcription (C)</p> Signup and view all the answers

What is the main function of regulatory proteins in hnRNA synthesis?

<p>Promote mRNA splicing (A)</p> Signup and view all the answers

What is the role of RNA polymerase in gene expression?

<p>Facilitating transcription (A)</p> Signup and view all the answers

Which codon signals for the termination of protein synthesis?

<p>UAA (D)</p> Signup and view all the answers

What are the main roles of noncoding DNA regions?

<p>Regulate gene expression (D)</p> Signup and view all the answers

Which component is repeated at the ends of linear chromosomes to protect them from degradation?

<p>Telomeres (C)</p> Signup and view all the answers

What is the significance of the TTAGGG sequence in telomeres?

<p>Prevent chromosome shortening (D)</p> Signup and view all the answers

What is the effect of a mutation in the stop codon sequence?

<p>Results in premature termination of translation (B)</p> Signup and view all the answers

How do telomeres contribute to maintaining genome stability?

<p>Prevent chromosomal fusions and degradation (D)</p> Signup and view all the answers

What is the primary function of noncoding regions in DNA?

<p>Regulate gene expression (D)</p> Signup and view all the answers

Which genetic element ensures accurate and complete chromosome replication during cell division?

<p>Telomeres (D)</p> Signup and view all the answers

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