NCERT - PRINCIPLES OF INHERITANCE & VARIATION - 24-25

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Questions and Answers

What is the term for genes that code for contrasting traits?

  • Chromosomes
  • Phenotypes
  • Alleles (correct)
  • Genotypes

The phenotype of a plant with a genotype Tt will be dwarf.

False (B)

What represents the alleles for height in pea plants?

T and t

In true breeding plants, the allelic pairs are said to be _____ for height.

<p>homozygous</p> Signup and view all the answers

Match the genotype with its corresponding phenotype:

<p>TT = Tall tt = Dwarf Tt = Dwarf</p> Signup and view all the answers

Which of the following represents a homozygous genotype for height?

<p>Both B and C (B)</p> Signup and view all the answers

Mendel found that in a pair of dissimilar traits, one trait can dominate the other.

<p>True (A)</p> Signup and view all the answers

What is the result when alleles IA and IB are present together?

<p>Both IA and IB express their types of sugars (A)</p> Signup and view all the answers

What is the phenotype of a plant with the genotype Tt?

<p>Tall</p> Signup and view all the answers

Allele i produces a form of sugar.

<p>False (B)</p> Signup and view all the answers

How many phenotypes are possible for the ABO blood types?

<p>Four</p> Signup and view all the answers

What was one of the contrasting traits studied by Mendel in pea plants?

<p>Smooth or wrinkled seeds (C)</p> Signup and view all the answers

Mendel's experiments used a small sampling size to increase the credibility of his data.

<p>False (B)</p> Signup and view all the answers

The phenomenon where two different alleles express themselves equally is called ______.

<p>co-dominance</p> Signup and view all the answers

Match the allele with its corresponding blood type:

<p>IA = Type A IB = Type B IAIB = Type AB ii = Type O</p> Signup and view all the answers

What is a true-breeding plant?

<p>A plant that shows stable trait inheritance and expression for several generations through self-pollination.</p> Signup and view all the answers

What type of inheritance is shown in the example of starch synthesis in pea seeds?

<p>Multiple alleles (C)</p> Signup and view all the answers

Mendel conducted _____ experiments using several true-breeding pea lines.

<p>cross-pollination</p> Signup and view all the answers

Match the following virtues with their corresponding contrasting traits studied by Mendel:

<p>Tall = Dwarf Yellow seeds = Green seeds Inflated pods = Constricted pods Smooth seeds = Wrinkled seeds</p> Signup and view all the answers

An individual can possess more than two alleles for a single gene at one time.

<p>False (B)</p> Signup and view all the answers

Which of these traits is NOT one of the contrasting traits that Mendel studied?

<p>Yellow or blue flowers (C)</p> Signup and view all the answers

What are the genotypes of blood type O?

<p>ii</p> Signup and view all the answers

Mendel's findings were based solely on theories without any experimental support.

<p>False (B)</p> Signup and view all the answers

What did Mendel's experiments contribute to the understanding of genetics?

<p>They pointed to general rules of inheritance.</p> Signup and view all the answers

What is the phenotypic ratio among the plants in the F2 generation?

<p>3:1 (D)</p> Signup and view all the answers

All F1 plants have the same genotype of Tt.

<p>True (A)</p> Signup and view all the answers

What are the genotypes produced from the self-pollination of F1 plants?

<p>TT, Tt, tt</p> Signup and view all the answers

The dominant phenotype expressed in the F1 generation is ______.

<p>tall</p> Signup and view all the answers

What is the genotypic ratio in the F2 generation?

<p>1:2:1 (D)</p> Signup and view all the answers

The F2 generation contains only dominant tall plants.

<p>False (B)</p> Signup and view all the answers

What conclusion did Mendel draw about the genotype of the dwarf plants?

<p>Homozygous – tt</p> Signup and view all the answers

Which type of allele is usually associated with producing a non-functional enzyme?

<p>Recessive allele (C)</p> Signup and view all the answers

The F1 generation in co-dominance resembles only one parent.

<p>False (B)</p> Signup and view all the answers

What type of inheritance involves multiple genes controlling a trait?

<p>Polygenic inheritance (D)</p> Signup and view all the answers

What are the three alleles that control the ABO blood grouping in human beings?

<p>IA, IB, i</p> Signup and view all the answers

Pleiotropic genes can cause multiple phenotypic expressions from a single gene.

<p>True (A)</p> Signup and view all the answers

Name a classic example of a polygenic trait in humans.

<p>Skin color</p> Signup and view all the answers

In a monohybrid cross, the presence of __________ determines the phenotype when paired with a recessive allele.

<p>dominant allele</p> Signup and view all the answers

Match the allele types with their characteristics:

<p>Dominant allele = Produces the expressed trait Recessive allele = May lead to non-functional traits Modified allele = Can be equivalent to dominant allele Co-dominant allele = Expresses traits from both parents</p> Signup and view all the answers

The genotype with all dominant alleles for skin color is represented as ______.

<p>AABBCC</p> Signup and view all the answers

Which of the following traits in humans is considered a result of pleiotropy?

<p>Phenylketonuria (A)</p> Signup and view all the answers

What happens when a modified allele produces a normal enzyme?

<p>It is equivalent to the unmodified allele (A)</p> Signup and view all the answers

In incomplete dominance, the F1 generation presents traits that are a mix of both parents.

<p>True (A)</p> Signup and view all the answers

Match the following terms with their definitions:

<p>Polygenic inheritance = Trait controlled by multiple genes Pleiotropy = Single gene affects multiple traits Dominant allele = Allele that expresses when present Recessive allele = Requires two copies for expression</p> Signup and view all the answers

The height of individuals is an example of monogenic inheritance.

<p>False (B)</p> Signup and view all the answers

What is the result when the recessive trait is expressed due to a non-functional enzyme?

<p>The phenotype displays the recessive attribute.</p> Signup and view all the answers

What is the role of the gene that causes phenylketonuria?

<p>It codes for the enzyme phenyl alanine hydroxylase.</p> Signup and view all the answers

What discovery allowed scientists to observe cell division more clearly in the early 1900s?

<p>Microscopic technology improvements (D)</p> Signup and view all the answers

Mendel's work was recognized immediately after he published his findings in 1865.

<p>False (B)</p> Signup and view all the answers

What parallel did Walter Sutton and Theodore Boveri observe between chromosomes and genes?

<p>The behavior of chromosomes is parallel to the behavior of genes.</p> Signup and view all the answers

Mendel's concept of genes as stable and discrete units that controlled traits was initially _____ by many biologists.

<p>rejected</p> Signup and view all the answers

Match the following scientists with their contributions related to Mendel's work:

<p>Mendel = Established the laws of inheritance de Vries = Rediscovered Mendel's principles independently Sutton = Noted the parallel between chromosomes and genes Boveri = Contributed to the chromosome theory of inheritance</p> Signup and view all the answers

Which of the following best describes chromosomes?

<p>Discreet units of inheritance visible during cell division (B)</p> Signup and view all the answers

Mendel's mathematical approach helped clarify biological phenomena in his time.

<p>False (B)</p> Signup and view all the answers

What chromosomes determine female characteristics in birds?

<p>ZW chromosomes (B)</p> Signup and view all the answers

What important concept did Mendel devise about alleles?

<p>Alleles do not blend with each other.</p> Signup and view all the answers

Human males produce only one type of gamete carrying either an X or Y chromosome.

<p>False (B)</p> Signup and view all the answers

What is the genetic composition of the zygote if the ovum fertilizes with a sperm carrying an X chromosome?

<p>XX</p> Signup and view all the answers

In human beings, the sex determining mechanism is of the _____ type.

<p>XY</p> Signup and view all the answers

Match the type of gamete production with their respective sex determination mechanism:

<p>Males (humans) = Produces X and Y gametes Females (birds) = Produces Z and W gametes Males (birds) = Produces Z gametes Females (humans) = Produces X gametes</p> Signup and view all the answers

What is the probability of having a female child during each pregnancy in humans?

<p>50% (D)</p> Signup and view all the answers

Females in humans can produce two types of gametes.

<p>False (B)</p> Signup and view all the answers

What degree did James Dewey Watson obtain in 1947?

<p>B.Sc. in Zoology (D)</p> Signup and view all the answers

What are the sex chromosomes present in human males?

<p>XY</p> Signup and view all the answers

Francis Crick was born in Chicago, Illinois.

<p>False (B)</p> Signup and view all the answers

What significant discovery did Watson and Crick propose in March 1953?

<p>The double-helical structure of DNA</p> Signup and view all the answers

Crick completed his Ph.D. in _____ on a thesis about X-ray diffraction.

<p>1954</p> Signup and view all the answers

Match the scientist to their contribution:

<p>James Watson = Discovered the DNA double helix Francis Crick = Ph.D. on X-ray diffraction Mendel = Principles of inheritance Hershey and Chase = Confirmed DNA as the genetic material</p> Signup and view all the answers

What influenced Francis Crick's career significantly?

<p>His friendship with Watson (B)</p> Signup and view all the answers

James Watson and Francis Crick received the Nobel Prize for their work on the DNA structure in 1962.

<p>True (A)</p> Signup and view all the answers

What field of science addresses questions related to inheritance and variation in organisms?

<p>Genetics</p> Signup and view all the answers

Which genotype results from self-pollination of F1 plants of genotype Tt?

<p>All of the above (D)</p> Signup and view all the answers

The phenotype of a plant with the genotype TT can be distinguished from that of a plant with the genotype Tt.

<p>False (B)</p> Signup and view all the answers

What is the phenotypic ratio of tall to dwarf plants in the F2 generation?

<p>3:1</p> Signup and view all the answers

The dominant allele for height in pea plants is represented by the letter _____.

<p>T</p> Signup and view all the answers

Match the genotype with its corresponding phenotypic expression:

<p>TT = Tall Tt = Tall tt = Dwarf</p> Signup and view all the answers

What conclusion can be drawn about the genotype of dwarf plants?

<p>They are homozygous. (C)</p> Signup and view all the answers

All F1 plants from the Tt genotype are dwarf.

<p>False (B)</p> Signup and view all the answers

How did Mendel determine the genotype of dwarf plants from his experiments?

<p>He observed that dwarf F2 plants produced only dwarf offspring.</p> Signup and view all the answers

Which column in the comparison represents chromosomes?

<p>Column A (C)</p> Signup and view all the answers

Independent assortment allows chromosome pairs to segregate in a way that one pair affects the segregation of another pair.

<p>False (B)</p> Signup and view all the answers

What is the significance of the chromosomal theory of inheritance?

<p>It unites the principles of chromosomal segregation with Mendelian inheritance.</p> Signup and view all the answers

During Anaphase of meiosis I, genetic variation is introduced through __________ of chromosome pairs.

<p>independent assortment</p> Signup and view all the answers

Match the following concepts with their descriptions:

<p>Chromosomal Segregation = Process during meiosis that involves the separation of chromosomes. Independent Assortment = Random distribution of chromosome pairs during gamete formation. Mendelian Principles = Fundamental rules that govern inheritance patterns. Drosophila melanogaster = Common model organism for genetic studies.</p> Signup and view all the answers

Which of the following best describes Drosophila melanogaster?

<p>A tiny fruit fly suitable for genetic experiments (C)</p> Signup and view all the answers

The life cycle of Drosophila melanogaster can be completed in approximately __________.

<p>two weeks</p> Signup and view all the answers

Thomas Hunt Morgan was instrumental in experimentally verifying the chromosomal theory of inheritance.

<p>True (A)</p> Signup and view all the answers

What phenotype does the F1 generation exhibit in the case of incomplete dominance with red and white flowered plants?

<p>Pink (D)</p> Signup and view all the answers

In incomplete dominance, the F2 generation shows a 3:1 ratio of phenotypes.

<p>False (B)</p> Signup and view all the answers

What is the genotypic ratio of the F2 generation from the self-pollination of the F1 generation in the example of incomplete dominance?

<p>1 RR : 2 Rr : 1 rr</p> Signup and view all the answers

In the case of Antirrhinum sp., true-breeding red flowers have the genotype _____ and true-breeding white flowers have the genotype _____.

<p>RR, rr</p> Signup and view all the answers

Match the genotype with the corresponding phenotype in the context of incomplete dominance.

<p>RR = Red flower Rr = Pink flower rr = White flower</p> Signup and view all the answers

How are alleles expressed in a heterozygote in the case of incomplete dominance?

<p>Both alleles are expressed equally. (C)</p> Signup and view all the answers

Alleles can be completely dominant, recessive, or incompletely dominant.

<p>True (A)</p> Signup and view all the answers

Define incomplete dominance.

<p>A genetic phenomenon where the heterozygous phenotype is a blend of both alleles.</p> Signup and view all the answers

What is the phenotype of a plant with a genotype of TT?

<p>Tall (C)</p> Signup and view all the answers

Alleles are identical forms of a gene.

<p>False (B)</p> Signup and view all the answers

What does the term 'homozygous' refer to in relation to alleles?

<p>Having two identical alleles for a particular gene.</p> Signup and view all the answers

In a monohybrid cross, the genotype of the F1 generation is typically represented as _____ when one allele is dominant.

<p>heterozygous</p> Signup and view all the answers

Match the genotype with its corresponding description:

<p>TT = Homozygous dominant tt = Homozygous recessive Tt = Heterozygous T = Dominant allele</p> Signup and view all the answers

Which statement best describes the relationship between dominant and recessive traits?

<p>In a heterozygote, the dominant trait will mask the recessive trait. (B)</p> Signup and view all the answers

The phenotype of the F1 generation will always reflect the recessive trait.

<p>False (B)</p> Signup and view all the answers

What allele represents the recessive trait for height in pea plants?

<p>t</p> Signup and view all the answers

What is the karyotype of an individual with Klinefelter’s Syndrome?

<p>47, XXY (C)</p> Signup and view all the answers

Individuals with Turner’s Syndrome have normal ovaries.

<p>False (B)</p> Signup and view all the answers

What term describes the phenomenon where one trait is completely dominant over another?

<p>Law of Dominance</p> Signup and view all the answers

A female with Turner’s Syndrome has a karyotype of _____ with X0.

<p>45</p> Signup and view all the answers

Match the genetic disorders with their characteristics:

<p>Klinefelter’s Syndrome = 47, XXY, sterile males with feminine traits Turner’s Syndrome = 45, X0, sterile females with rudimentary ovaries</p> Signup and view all the answers

Which of the following statements about Mendel's work is correct?

<p>Mendel's laws include the Law of Segregation. (A)</p> Signup and view all the answers

All individuals with Klinefelter’s Syndrome express exclusively feminine traits.

<p>False (B)</p> Signup and view all the answers

What is a common characteristic of individuals with Klinefelter’s Syndrome?

<p>They are sterile.</p> Signup and view all the answers

What determines the sex of honey bees?

<p>The number of chromosomes (D)</p> Signup and view all the answers

Honey bee males have the same number of chromosomes as females.

<p>False (B)</p> Signup and view all the answers

What is the total number of chromosomes for a female honey bee?

<p>32</p> Signup and view all the answers

Males develop from ______ eggs in honey bees.

<p>unfertilized</p> Signup and view all the answers

What type of mutation results in the alteration of a single base pair of DNA?

<p>Point mutation (A)</p> Signup and view all the answers

Match the type of mutation with its description:

<p>Point mutation = Alteration of a single base pair Frame-shift mutation = Caused by deletions or insertions Chromosomal aberration = Commonly observed in cancer cells Duplication = Increase in the number of DNA segments</p> Signup and view all the answers

Males in honey bees do not have a father.

<p>True (A)</p> Signup and view all the answers

Name a classical example of a mutation affecting phenotype.

<p>Sickle cell anemia</p> Signup and view all the answers

In XO type of sex determination, which of the following statements is true?

<p>Males have one X-chromosome and no Y-chromosome. (C)</p> Signup and view all the answers

In humans, males have a pair of XX chromosomes.

<p>False (B)</p> Signup and view all the answers

What is the sex determination mechanism present in many birds?

<p>ZW mechanism</p> Signup and view all the answers

In the XX-XY sex determination system, the male is referred to as ______.

<p>heterogametic</p> Signup and view all the answers

Match the following species with their corresponding sex determination system:

<p>Grasshopper = XO type Human = XY type Bird = ZW type Drosophila = XY type</p> Signup and view all the answers

Which sex chromosome pair do females possess in both humans and Drosophila?

<p>XX (B)</p> Signup and view all the answers

All male birds have the same chromosomes as female birds.

<p>False (B)</p> Signup and view all the answers

In sex determination systems, chromosomes that are not involved in sex determination are termed ______.

<p>autosomes</p> Signup and view all the answers

What is the term used to describe agents that induce mutations?

<p>Mutagens (C)</p> Signup and view all the answers

UV radiation is considered a mutagen.

<p>True (A)</p> Signup and view all the answers

What process is used to analyze the inheritance pattern of traits in humans?

<p>Pedigree analysis</p> Signup and view all the answers

An alteration in the genetic material is referred to as a _____.

<p>mutation</p> Signup and view all the answers

Which of the following best describes the purpose of pedigree analysis?

<p>To trace the inheritance of traits across generations (D)</p> Signup and view all the answers

Changes in DNA are always harmful to the organism.

<p>False (B)</p> Signup and view all the answers

What role does DNA play in genetics?

<p>DNA carries genetic information from one generation to the next.</p> Signup and view all the answers

Which of the following disorders is an example of a Mendelian disorder?

<p>Cystic fibrosis (A)</p> Signup and view all the answers

Colour blindness is transmitted from father to daughter.

<p>False (B)</p> Signup and view all the answers

What is the pattern of inheritance observed for Haemophilia?

<p>X-linked recessive</p> Signup and view all the answers

The chance of a son being color blind if his mother is a carrier is ______ percent.

<p>50</p> Signup and view all the answers

Match the following Mendelian disorders with their characteristics:

<p>Haemophilia = X-linked recessive disorder affecting blood clotting Sickle-cell anaemia = Autosomal recessive disorder affecting red blood cells Phenylketonuria = Autosomal recessive disorder resulting in the inability to process phenylalanine Thalassemia = Autosomal recessive disorder affecting hemoglobin production</p> Signup and view all the answers

Which statement is true about the inheritance of Mendelian disorders?

<p>They may be dominant or recessive in inheritance. (C)</p> Signup and view all the answers

Mendelian disorders can be identified using pedigree analysis.

<p>True (A)</p> Signup and view all the answers

Name a common Mendelian disorder that affects the ability to clot blood.

<p>Haemophilia</p> Signup and view all the answers

Which of the following statements best describes the Law of Independent Assortment?

<p>Gametes combine in random permutations. (C)</p> Signup and view all the answers

Linked genes are genes that assort independently from one another.

<p>False (B)</p> Signup and view all the answers

What are the male and female sex chromosomes in humans?

<p>Male: XY; Female: XX</p> Signup and view all the answers

Down’s syndrome is caused by _____ of chromosome 21.

<p>trisomy</p> Signup and view all the answers

Which type of mutation involves a change in a single base pair?

<p>Point mutation (D)</p> Signup and view all the answers

Match the following genetic disorders with their descriptions:

<p>Down's syndrome = Trisomy of chromosome 21 Turner's syndrome = XO sex chromosome configuration Klinefelter's syndrome = XXY sex chromosome configuration</p> Signup and view all the answers

What is the chromosomal configuration in females in chickens?

<p>ZW</p> Signup and view all the answers

Phenotypes express genetic traits regardless of the underlying genotype.

<p>True (A)</p> Signup and view all the answers

What does the Law of Dominance state?

<p>Only one member of a dissimilar pair of factors dominates the other. (C)</p> Signup and view all the answers

In a test cross, a dominant phenotype is crossed with a homozygous dominant parent.

<p>False (B)</p> Signup and view all the answers

What did Morgan observe about the F2 ratio in his dihybrid crosses?

<p>It deviated significantly from the expected ratio (D)</p> Signup and view all the answers

All genes located on the same chromosome show tight linkage and minimal recombination.

<p>False (B)</p> Signup and view all the answers

What ratio is typically observed in the F2 generation of a monohybrid cross?

<p>3:1</p> Signup and view all the answers

The process of determining the genotype of an organism by crossing it with a recessive organism is known as a _____ cross.

<p>test</p> Signup and view all the answers

What term did Morgan use to describe the physical association of genes on a chromosome?

<p>linkage</p> Signup and view all the answers

Match the components of Mendel's Laws with their descriptions:

<p>First Law (Law of Dominance) = One trait dominates the expression of another. Second Law (Law of Segregation) = Alleles segregate during gamete formation. Factors = Discrete units controlling characters. Homozygous = Two identical alleles for a trait.</p> Signup and view all the answers

The genes white and yellow in Drosophila showed only _____ percent recombination.

<p>1.3</p> Signup and view all the answers

Match the following pairs of genes with their recombination percentages:

<p>White and Yellow = 1.3% White and Miniature Wing = 37.2% Yellow and Brown = Varies Red and Brown = Low</p> Signup and view all the answers

Which statement correctly describes an allele?

<p>Alleles are forms of genes that control specific traits. (D)</p> Signup and view all the answers

The Law of Segregation states that both alleles of a gene blend together in gametes.

<p>False (B)</p> Signup and view all the answers

Which of the following statements about the dihybrid crosses in Drosophila is true?

<p>Two genes can show much higher parental combinations. (C)</p> Signup and view all the answers

Alfred Sturtevant used recombination frequency to map gene positions on chromosomes.

<p>True (A)</p> Signup and view all the answers

In a monohybrid cross involving tall (T) and dwarf (t) plants, what are the possible gametes produced by a heterozygous plant?

<p>T, t</p> Signup and view all the answers

What was the primary method Morgan used to study sex-linked genes in Drosophila?

<p>dihybrid crosses</p> Signup and view all the answers

All F1 generation plants exhibit dwarf characteristics.

<p>False (B)</p> Signup and view all the answers

What genotype represents a true-breeding dwarf plant?

<p>tt</p> Signup and view all the answers

The ratio of genotypes TT, Tt, and tt obtained from self-pollination is _____ : _____ : _____

<p>1 : 2 : 1</p> Signup and view all the answers

Match the genotype with its phenotypic expression:

<p>TT = Tall Tt = Tall tt = Dwarf</p> Signup and view all the answers

What would Mendel expect to occur if he self-pollinated a tall F2 plant?

<p>There would be a mixture of tall and dwarf offspring. (B)</p> Signup and view all the answers

The F2 generation contains only genotype Tt.

<p>False (B)</p> Signup and view all the answers

What does the symbol 'T' represent in the context of plant height?

<p>Tall allele</p> Signup and view all the answers

Which of the following disorders is primarily an X-linked recessive disorder?

<p>Colour blindness (D)</p> Signup and view all the answers

Mendelian disorders can only be dominant traits.

<p>False (B)</p> Signup and view all the answers

What type of genetic analysis is used to trace the inheritance of Mendelian disorders in families?

<p>pedigree analysis</p> Signup and view all the answers

Haemophilia is an example of a _____ disorder.

<p>Mendelian</p> Signup and view all the answers

What is the chance of a son of a carrier mother being colour blind?

<p>50% (D)</p> Signup and view all the answers

Males have two X chromosomes, which increases the likelihood of being affected by X-linked disorders.

<p>False (B)</p> Signup and view all the answers

Name one common Mendelian disorder that affects the blood's ability to clot.

<p>Haemophilia</p> Signup and view all the answers

What karyotype is associated with Klinefelter's Syndrome?

<p>47, XXY (D)</p> Signup and view all the answers

Individuals with Turner’s Syndrome have normally developed ovaries.

<p>False (B)</p> Signup and view all the answers

List one primary feature of individuals diagnosed with Klinefelter's Syndrome.

<p>Gynaecomastia</p> Signup and view all the answers

The presence of an additional copy of the X chromosome results in _____ development in Klinefelter's Syndrome.

<p>feminine</p> Signup and view all the answers

Which of the following statements describes Mendel's Law of Segregation?

<p>Alleles segregate when gametes are formed. (A)</p> Signup and view all the answers

Match the following syndromes with their characteristics:

<p>Klinefelter's Syndrome = 47, XXY, Gynaecomastia Turner's Syndrome = 45, X0, Rudimentary ovaries</p> Signup and view all the answers

Mendel's principles of inheritance are applicable to both plants and animals.

<p>True (A)</p> Signup and view all the answers

What phenomenon results in some characters being expressed in homozygous conditions but not in heterozygous conditions?

<p>Recessive inheritance</p> Signup and view all the answers

What type of plants did Mendel primarily use for his experiments?

<p>Garden pea plants (A)</p> Signup and view all the answers

Mendel's experiments had a small sampling size which decreased the credibility of the data he collected.

<p>False (B)</p> Signup and view all the answers

Mendel selected ___ true-breeding pea plant varieties for his studies.

<p>14</p> Signup and view all the answers

Which of the following is one of the contrasting traits studied by Mendel?

<p>Height - Tall/Dwarf (C)</p> Signup and view all the answers

Match the following traits with their contrasting characteristics:

<p>Stem height = Tall/Dwarf Seed color = Yellow/Green Pod shape = Inflated/Constricted Seed texture = Smooth/Wrinkled</p> Signup and view all the answers

What general rules did Mendel's results come to point towards?

<p>General rules of inheritance.</p> Signup and view all the answers

Mendel's work had no experimental support before being acknowledged in genetics.

<p>False (B)</p> Signup and view all the answers

What theory did Sutton unite with Mendelian principles regarding inheritance?

<p>Chromosomal theory of inheritance (B)</p> Signup and view all the answers

Independent assortment of chromosomes occurs during metaphase II of meiosis.

<p>False (B)</p> Signup and view all the answers

What organism did Thomas Hunt Morgan use in his genetics experiments?

<p>Drosophila melanogaster</p> Signup and view all the answers

During gamete formation, chromosomes from each pair are __________ to gametes.

<p>segregated</p> Signup and view all the answers

Match the following aspects of chromosomes and genes:

<p>Occur in pairs = Chromosomes Independent pairs segregate = Genes Segregate at gamete formation = Both One of each pair transmitted to gamete = Chromosomes</p> Signup and view all the answers

What is the primary purpose of a test cross?

<p>To identify if an organism is homozygous or heterozygous (A)</p> Signup and view all the answers

What advantage does Drosophila melanogaster present in genetic research?

<p>Large number of offspring (C)</p> Signup and view all the answers

The Law of Segregation states that alleles blend together during gamete formation.

<p>False (B)</p> Signup and view all the answers

What flower color in pea plants is dominant according to Mendel's findings?

<p>Violet</p> Signup and view all the answers

Mendel's experiments with pea plants were conducted in a natural environment without control.

<p>False (B)</p> Signup and view all the answers

What process leads to the variation produced by sexual reproduction according to the chromosomal theory of inheritance?

<p>Segregation and independent assortment of chromosomes</p> Signup and view all the answers

The expression of only one parental character in the F1 generation can be explained by the __________.

<p>Law of Dominance</p> Signup and view all the answers

Match the following laws of inheritance with their descriptions:

<p>Law of Dominance = Explains dominant and recessive traits Law of Segregation = Describes how alleles segregate during gamete formation</p> Signup and view all the answers

What phenotypic ratio is expected in the F2 generation of a monohybrid cross?

<p>3:1 (C)</p> Signup and view all the answers

A homozygous parent produces two different types of gametes.

<p>False (B)</p> Signup and view all the answers

Define a test cross in your own words.

<p>A test cross is a breeding experiment used to determine the genotype of an organism with a dominant phenotype by crossing it with a recessive organism.</p> Signup and view all the answers

Which mechanism describes males producing two different types of gametes, either with or without an X-chromosome?

<p>Male heterogamety (C)</p> Signup and view all the answers

In humans, females have two X-chromosomes and males have one X and one Y chromosome.

<p>True (A)</p> Signup and view all the answers

What are the two types of gametes produced by males during spermatogenesis?

<p>X-chromosome and Y-chromosome</p> Signup and view all the answers

In birds, females have one Z and one _____ chromosome.

<p>W</p> Signup and view all the answers

What is the probability of having a male or female offspring in humans?

<p>50% (C)</p> Signup and view all the answers

Match the sex determination mechanisms with the correct descriptions:

<p>Male heterogamety = Males produce gametes with X and Y chromosomes Female heterogamety = Females produce gametes with Z and W chromosomes Human sex determination = Males have X and Y, females have two X chromosomes Bird sex determination = Same chromosome number but different sex chromosomes for females</p> Signup and view all the answers

The genetic makeup of the ovum determines the sex of the child in humans.

<p>False (B)</p> Signup and view all the answers

What are the sex chromosomes present in female birds?

<p>Z and W</p> Signup and view all the answers

What is the chromosome number in male honey bees?

<p>16 (B)</p> Signup and view all the answers

Honey bee males develop from fertilized eggs.

<p>False (B)</p> Signup and view all the answers

What type of sex-determination system do honey bees exhibit?

<p>Haplodiploid sex-determination system</p> Signup and view all the answers

Honey bees have ____ chromosomes, while drones have ____ chromosomes.

<p>32, 16</p> Signup and view all the answers

Which of the following mutations is caused by a change in a single base pair of DNA?

<p>Point mutation (A)</p> Signup and view all the answers

Chromosomal aberrations are often found in healthy, non-cancerous cells.

<p>False (B)</p> Signup and view all the answers

Match the following types of mutations with their descriptions:

<p>Point mutation = Change in a single base pair Frame-shift mutation = Involves deletions or insertions causing shifts in reading frame Deletion mutation = Loss of a segment of DNA Insertion mutation = Gain of a segment of DNA</p> Signup and view all the answers

What is one classical example of a point mutation?

<p>Sickle cell anemia</p> Signup and view all the answers

Haemophilia is a recessive disorder linked to the X chromosome.

<p>True (A)</p> Signup and view all the answers

What is the typical inheritance pattern of colour blindness in males?

<p>Males inherit colour blindness from carrier females, having a 50% chance of being affected.</p> Signup and view all the answers

The disorder resulting in the inability to properly metabolize phenylalanine is called _____

<p>Phenylketonuria</p> Signup and view all the answers

What percentage of males is affected by colour blindness?

<p>8% (D)</p> Signup and view all the answers

A daughter of a carrier mother for colour blindness will always be colour blind.

<p>False (B)</p> Signup and view all the answers

What type of genetic traits can be determined through pedigree analysis?

<p>Mendelian traits and their inheritance patterns.</p> Signup and view all the answers

In Mendel's experiments, what was the observed phenotypic ratio among the F2 generation plants?

<p>3:1 (A)</p> Signup and view all the answers

All F1 progeny plants in Mendel's crosses were a blend of their parental traits.

<p>False (B)</p> Signup and view all the answers

What term did Mendel use to refer to the units of inheritance?

<p>factors</p> Signup and view all the answers

The two contrasting traits of pea plants that Mendel studied included tall and _____ plants.

<p>dwarf</p> Signup and view all the answers

Match the following traits with their respective options:

<p>Flower Colour = Violet/White Pod Shape = Inflated/Constricted Seed Colour = Yellow/Green Seed Shape = Round/Wrinkled</p> Signup and view all the answers

During self-pollination of the tall F1 plants, what unexpected result did Mendel find in the F2 generation?

<p>Some plants were dwarf (C)</p> Signup and view all the answers

Mendel's studies concluded that traits could blend in offspring.

<p>False (B)</p> Signup and view all the answers

What does the term 'Filial1' refer to in Mendel's experiments?

<p>First hybrid generation</p> Signup and view all the answers

What type of gametes do males produce in male heterogamety?

<p>Either X-chromosome or Y-chromosome gametes (C)</p> Signup and view all the answers

In birds, males have a pair of Z-chromosomes while females have one Z and one W chromosome.

<p>True (A)</p> Signup and view all the answers

What chromosome pair is present in females in the XY sex determination system?

<p>XX</p> Signup and view all the answers

The sex of a child in humans is determined by the genetic makeup of the _____.

<p>sperm</p> Signup and view all the answers

Match the following organisms with their sex determination mechanisms:

<p>Males = Male heterogamety Females (Birds) = Female heterogamety Humans = XY sex determination Birds = ZW sex determination</p> Signup and view all the answers

What is the probability of having a male child if an ovum fertilizes with a Y-chromosome carrying sperm?

<p>50% (D)</p> Signup and view all the answers

Women are solely responsible for the sex of the child, where female children are the result of their genetic contribution.

<p>False (B)</p> Signup and view all the answers

What type of chromosomes are present in male birds according to their sex determination mechanism?

<p>ZZ</p> Signup and view all the answers

What is the dominant allele for seed shape in the described pea plant crosses?

<p>Round (R) (D)</p> Signup and view all the answers

The phenotype of the heterozygous Bb seeds is larger than the phenotype of the homozygous BB seeds.

<p>False (B)</p> Signup and view all the answers

What phenotypic ratio is observed for yellow to green seeds in the F2 generation?

<p>3:1</p> Signup and view all the answers

In Mendel's pea plant experiments, the allele for yellow seeds is designated as _____ and the allele for green seeds is designated as _____.

<p>Y, y</p> Signup and view all the answers

Match the following seed traits with their dominant or recessive status:

<p>Yellow seed color = Dominant Green seed color = Recessive Round seed shape = Dominant Wrinkled seed shape = Recessive</p> Signup and view all the answers

What type of inheritance is illustrated by the starch grain sizes in homozygous and heterozygous pea seeds?

<p>Incomplete dominance (D)</p> Signup and view all the answers

Which column represents chromosomes and which represents genes?

<p>Column A represents chromosomes and Column B represents genes (D)</p> Signup and view all the answers

Sutton and Boveri proposed that the segregation of chromosomes leads to the segregation of genes.

<p>True (A)</p> Signup and view all the answers

What does the cross between genotype RRYY and rryy produce in the F1 generation?

<p>RrYy</p> Signup and view all the answers

What is the main organism used by Thomas Hunt Morgan to study inheritance?

<p>Drosophila melanogaster</p> Signup and view all the answers

Heterozygous Bb seeds produce the largest starch grains compared to other genotypes.

<p>False (B)</p> Signup and view all the answers

During ______, chromosome pairs can align independently at the metaphase plate.

<p>Anaphase I</p> Signup and view all the answers

What is a key characteristic of independent assortment observed during meiosis?

<p>The segregation of one pair does not affect the other pairs (D)</p> Signup and view all the answers

The life cycle of Drosophila melanogaster takes about two months to complete.

<p>False (B)</p> Signup and view all the answers

Who experimentally verified the chromosomal theory of inheritance?

<p>Thomas Hunt Morgan</p> Signup and view all the answers

What are mutagens?

<p>Factors that induce mutations (C)</p> Signup and view all the answers

Pedigree analysis is used to study the inheritance of traits in plants only.

<p>False (B)</p> Signup and view all the answers

What is DNA's role in genetics?

<p>DNA serves as the carrier of genetic information.</p> Signup and view all the answers

An alteration in the genetic material is known as a _____ .

<p>mutation</p> Signup and view all the answers

Which of the following can cause mutations?

<p>UV radiation (A)</p> Signup and view all the answers

Each feature in an organism is controlled by multiple genes located throughout the DNA.

<p>False (B)</p> Signup and view all the answers

What is represented in a pedigree analysis?

<p>The inheritance of a particular trait over generations in a family.</p> Signup and view all the answers

What is the total number of chromosomes in a normal human cell?

<p>46 (A)</p> Signup and view all the answers

Down's syndrome is caused by having an extra copy of chromosome 21.

<p>True (A)</p> Signup and view all the answers

What is the term for the situation where an individual has an additional chromosome?

<p>trisomy</p> Signup and view all the answers

Individuals with __________ syndrome may have short stature and other physical anomalies.

<p>Turner’s</p> Signup and view all the answers

Which of the following is a common characteristic of Down's syndrome?

<p>Short stature with a broad flat face (D)</p> Signup and view all the answers

Match the following chromosomal disorders with their characteristics:

<p>Down’s syndrome = Trisomy of chromosome 21 Turner’s syndrome = Missing an X chromosome Klinefelter’s syndrome = Extra X chromosome in males Monosomy = Lack of one chromosome from a pair</p> Signup and view all the answers

Monosomy refers to the presence of an additional chromosome.

<p>False (B)</p> Signup and view all the answers

What genetic feature is typically observed in individuals with Down's syndrome?

<p>Broad palm with characteristic palm crease</p> Signup and view all the answers

What structure did Henking name after tracing it during spermatogenesis in insects?

<p>X body (D)</p> Signup and view all the answers

In the XO system of sex determination, males have an additional chromosome compared to females.

<p>False (B)</p> Signup and view all the answers

What happens to eggs fertilised by sperm that do not carry an X-chromosome?

<p>They become males.</p> Signup and view all the answers

Henking's observations led to the understanding of the _______ basis of sex-determination in insects.

<p>chromosomal</p> Signup and view all the answers

What does the capital letter in gene representation signify?

<p>The dominant trait expressed at the F1 stage (A)</p> Signup and view all the answers

Tallness is dominant over dwarfness in pea plants.

<p>True (A)</p> Signup and view all the answers

What is the genotype of a true-breeding dwarf pea plant?

<p>tt</p> Signup and view all the answers

In genetics, two different forms of the same gene are known as _____ .

<p>alleles</p> Signup and view all the answers

Match the genotype with its description:

<p>TT = Homozygous dominant tt = Homozygous recessive Tt = Heterozygous T = Allele for tallness</p> Signup and view all the answers

Which phenotype would a Tt plant exhibit?

<p>Tall (D)</p> Signup and view all the answers

Mendel's studies indicated that the genotype is the visible expression of a trait.

<p>False (B)</p> Signup and view all the answers

What term describes the physical expression of a genotype?

<p>phenotype</p> Signup and view all the answers

What does the term 'linkage' refer to in genetics?

<p>The physical association of genes on the same chromosome (D)</p> Signup and view all the answers

Which statement describes how chromosomes behave during gamete formation?

<p>Only one member of each chromosome pair is transmitted to a gamete. (D)</p> Signup and view all the answers

Sutton and Boveri proposed that the pairing and separation of chromosomes leads to the segregation of alleles.

<p>True (A)</p> Signup and view all the answers

Morgan discovered that the F2 ratio in dihybrid crosses deviated significantly from the expected 9:3:3:1 ratio due to independent assortment.

<p>False (B)</p> Signup and view all the answers

What percentage of recombination was observed between the tightly linked genes white and yellow?

<p>1.3 percent</p> Signup and view all the answers

What type of organism did Thomas Hunt Morgan use for his experiments on inheritance?

<p>Drosophila melanogaster</p> Signup and view all the answers

The chromosomal theory of inheritance was based on the work of __________ and Boveri.

<p>Sutton</p> Signup and view all the answers

The term _____ refers to the generation of non-parental gene combinations.

<p>recombination</p> Signup and view all the answers

Which of the following was a method used by Morgan to study sex-linked genes?

<p>Dihybrid crosses in Drosophila (A)</p> Signup and view all the answers

During which phase of meiosis do chromosomes align at the metaphase plate independently?

<p>Meiosis I (B)</p> Signup and view all the answers

What is the primary reason for higher proportions of parental gene combinations in linked genes?

<p>Physical proximity on the same chromosome (C)</p> Signup and view all the answers

Genes and chromosomes behave in exactly the same way during inheritance.

<p>False (B)</p> Signup and view all the answers

What is the significance of independent assortment in genetics?

<p>It leads to genetic variation in offspring.</p> Signup and view all the answers

Who was the student of Morgan that contributed to genetic mapping?

<p>Alfred Sturtevant</p> Signup and view all the answers

Which of the following traits is an example of polygenic inheritance?

<p>Human height (A)</p> Signup and view all the answers

Pleiotropic genes can only affect a single phenotype.

<p>False (B)</p> Signup and view all the answers

What is the dominant genotype for skin color according to the described polygenic trait?

<p>AABBCC</p> Signup and view all the answers

Phenylketonuria is an example of a disorder caused by a mutation in a gene that codes for ______.

<p>enzyme</p> Signup and view all the answers

Match the following traits with their descriptions:

<p>Height = Polygenic trait Phenylketonuria = Pleiotropic condition Skin color = Affected by multiple genes Male/Female = Determined by sex chromosomes</p> Signup and view all the answers

Which of the following best describes how polygenic traits function?

<p>They involve multiple genes and exhibit additive effects. (D)</p> Signup and view all the answers

The phenotype of an individual with the genotype aabbcc will have the darkest skin color.

<p>False (B)</p> Signup and view all the answers

Identify one trait in humans that exhibits pleiotropy.

<p>Phenylketonuria</p> Signup and view all the answers

What is the main result of the accumulation of phenylalanine in individuals with phenylketonuria?

<p>Mental retardation (D)</p> Signup and view all the answers

Thalassemia is caused by the overproduction of hemoglobin chains.

<p>False (B)</p> Signup and view all the answers

What genetic mechanism causes phenylketonuria?

<p>Autosomal recessive inheritance</p> Signup and view all the answers

Down’s syndrome is caused by the gain of an extra copy of chromosome ______.

<p>21</p> Signup and view all the answers

Match the following conditions with their descriptions:

<p>Phenylketonuria = Lacks an enzyme converting phenylalanine to tyrosine Thalassemia = Reduced synthesis of globin chains Down's syndrome = Gain of an extra chromosome 21 Turner's syndrome = Loss of an X chromosome in females</p> Signup and view all the answers

Which type of thalassemia is associated with a defect in the alpha globin chain?

<p>Alpha Thalassemia (B)</p> Signup and view all the answers

Polyploidy occurs due to the gain of a chromosome.

<p>True (A)</p> Signup and view all the answers

What is the primary cause of Turner’s syndrome?

<p>Loss of an X chromosome</p> Signup and view all the answers

What is the primary field of study that deals with the questions related to inheritance and variation?

<p>Genetics (D)</p> Signup and view all the answers

James Watson was awarded the Nobel Prize in 1960.

<p>False (B)</p> Signup and view all the answers

Who were the two scientists credited with proposing the double-helical structure of DNA?

<p>James Watson and Francis Crick</p> Signup and view all the answers

Francis Crick completed his Ph.D. in ____ on a thesis about X-ray Diffraction.

<p>1954</p> Signup and view all the answers

Match the following scientists with their corresponding achievements:

<p>James Watson = Proposed the DNA structure in 1953 Francis Crick = Completed Ph.D. in X-ray Diffraction J.D. Watson = Known for bird-watching and genetics</p> Signup and view all the answers

In what year did Watson receive his B.Sc. degree?

<p>1947 (D)</p> Signup and view all the answers

The study of genetics only covers questions about human inheritance.

<p>False (B)</p> Signup and view all the answers

What method did Watson and Crick utilize to arrive at their proposal for DNA structure?

<p>Experimental evidence and nucleic acid literature</p> Signup and view all the answers

In Mendel's experiments with pea plants, what does the capital letter represent when coding for traits?

<p>The dominant trait (B)</p> Signup and view all the answers

In a monohybrid cross, Tt genotype will result in a dwarf phenotype.

<p>False (B)</p> Signup and view all the answers

What is the phenotypic outcome when a homozygous tall plant (TT) is crossed with a homozygous dwarf plant (tt)?

<p>All offspring will be tall (Tt).</p> Signup and view all the answers

In genetics, a pair of dissimilar alleles is referred to as _____.

<p>heterozygous</p> Signup and view all the answers

Which term is used to describe the physical appearance of an organism regarding a specific trait?

<p>Phenotype (B)</p> Signup and view all the answers

Alleles are identical forms of a gene found at the same locus on homologous chromosomes.

<p>True (A)</p> Signup and view all the answers

What was the key finding of Mendel regarding dominant and recessive traits?

<p>In a pair of dissimilar factors, one factor is dominant and masks the expression of the other recessive factor.</p> Signup and view all the answers

What term refers to the physical association of genes on a chromosome?

<p>Linkage (D)</p> Signup and view all the answers

Alfred Sturtevant determined the distance between genes based on recombination frequencies.

<p>True (A)</p> Signup and view all the answers

What fruit fly species did Morgan use for his dihybrid crosses?

<p>Drosophila</p> Signup and view all the answers

Match the following terms with their corresponding definitions:

<p>Linkage = Physical association of genes on the same chromosome Recombination = Generation of non-parental gene combinations Dihybrid Cross = Cross involving two traits Sex-linked genes = Genes located on the sex chromosomes</p> Signup and view all the answers

What observed ratio deviated from the expected 9:3:3:1 ratio in Morgan's experiments?

<p>Not applicable (B)</p> Signup and view all the answers

Morgan's crosses indicated that genes on different chromosomes segregate independently.

<p>False (B)</p> Signup and view all the answers

What was the main observation made by Morgan regarding parental gene combinations?

<p>Parental gene combinations were much higher than non-parental combinations.</p> Signup and view all the answers

What determines the sex of the child in humans?

<p>The genetic makeup of the sperm (D)</p> Signup and view all the answers

Females produce two different types of gametes in humans.

<p>False (B)</p> Signup and view all the answers

In humans, males possess one _____ chromosome and one _____ chromosome.

<p>X, Y</p> Signup and view all the answers

Match the sex determination mechanisms with their descriptions:

<p>Male heterogamety = Males produce gametes with X or Y chromosomes Female heterogamety = Females produce gametes with Z or W chromosomes XY sex determination = Humans having X and Y chromosomes ZW sex determination = Birds having Z and W chromosomes</p> Signup and view all the answers

What percentage of sperm produced by males carries the Y chromosome?

<p>50% (B)</p> Signup and view all the answers

There is an equal probability of fertilization resulting in male or female offspring.

<p>True (A)</p> Signup and view all the answers

Which chromosomes do female humans have?

<p>Two X chromosomes</p> Signup and view all the answers

Pleiotropic genes can affect multiple traits based on a single genetic mutation.

<p>True (A)</p> Signup and view all the answers

What are the dominant alleles for skin color as described in the content?

<p>A, B, C</p> Signup and view all the answers

The condition caused by a mutation in the gene coding for phenyl alanine hydroxylase is known as ______.

<p>phenylketonuria</p> Signup and view all the answers

Match the following examples with their type of inheritance:

<p>Height in humans = Polygenic inheritance Phenylketonuria = Pleiotropy ABO blood type = Multiple alleles Skin color = Polygenic inheritance</p> Signup and view all the answers

In polygenic inheritance, how does the contribution of each allele affect the phenotype?

<p>It is additive. (C)</p> Signup and view all the answers

Human skin color is determined by a single gene.

<p>False (B)</p> Signup and view all the answers

What range of skin colors is seen in humans, and what factors influence this range?

<p>A gradient of skin colors influenced by multiple genes and environmental factors.</p> Signup and view all the answers

What is the karyotype associated with Klinefelter's Syndrome?

<p>47, XXY (C)</p> Signup and view all the answers

Individuals with Turner’s Syndrome have a normal number of X chromosomes.

<p>False (B)</p> Signup and view all the answers

What is a notable physical characteristic of individuals with Klinefelter’s Syndrome?

<p>Gynaecomastia</p> Signup and view all the answers

Mendel proposed the principles of inheritance known as _______.

<p>Mendel’s Laws of Inheritance</p> Signup and view all the answers

Match the following genetic terms with their descriptions:

<p>Dominant alleles = Expressed in heterozygous condition Recessive alleles = Expressed in homozygous condition Homozygous condition = Two identical alleles Heterozygous condition = Two different alleles</p> Signup and view all the answers

Which of the following best describes the Law of Segregation?

<p>Alleles segregate during gamete formation. (D)</p> Signup and view all the answers

Incomplete dominance occurs when one allele fully masks the expression of another.

<p>False (B)</p> Signup and view all the answers

What condition leads to the development of rudimentary ovaries in Turner’s Syndrome?

<p>Absence of one X chromosome</p> Signup and view all the answers

What structure did Henking trace during spermatogenesis in insects?

<p>X body (A)</p> Signup and view all the answers

Sperms fertilized by eggs with no X-chromosome will result in males.

<p>True (A)</p> Signup and view all the answers

What type of sex determination mechanism is observed in a large number of insects?

<p>XO type</p> Signup and view all the answers

Henking's observations contributed to the understanding of the ____-chromosome's role in sex determination.

<p>X</p> Signup and view all the answers

Which of the following statements about alleles is true?

<p>Alleles can be dominant or recessive. (B)</p> Signup and view all the answers

In Mendel's experiments, the phenotype of the Tt genotype was not different from that of the TT genotype.

<p>True (A)</p> Signup and view all the answers

What does the term 'phenotype' refer to in the context of genetics?

<p>The observable traits of an organism.</p> Signup and view all the answers

The alleles TT and tt represent _____ genotypes for height in pea plants.

<p>homozygous</p> Signup and view all the answers

Match the following genotypes with their corresponding characteristics:

<p>TT = Homozygous dominant Tt = Heterozygous tt = Homozygous recessive T = Dominant allele</p> Signup and view all the answers

Which of the following accurately describes Mendel's dominant and recessive factors?

<p>The dominant factor masks the effect of the recessive factor. (A)</p> Signup and view all the answers

Individuals with the genotype Tt are considered homozygous for height.

<p>False (B)</p> Signup and view all the answers

What is the genotype of a true-breeding dwarf pea plant for height?

<p>tt</p> Signup and view all the answers

What was one reason Mendel's work on inheritance went unrecognized until 1900?

<p>The scientific community did not recognize genetic principles. (C)</p> Signup and view all the answers

Mendel's theory of inheritance included the concept that alleles blend together to form new traits.

<p>False (B)</p> Signup and view all the answers

Name one advancement that helped rediscover Mendel's results in the early 1900s.

<p>Advancements in microscopy</p> Signup and view all the answers

Mendel's experiments suggested that factors, which we now call _____, were discrete units controlling traits.

<p>genes</p> Signup and view all the answers

Match the following scientists with their contributions:

<p>Mendel = Proposed the laws of inheritance Sutton = Established the chromosome theory of inheritance Boveri = Behavior of chromosomes during meiosis de Vries = Rediscovered Mendel's work</p> Signup and view all the answers

In which year did Mendel publish his work on inheritance?

<p>1865 (B)</p> Signup and view all the answers

Chromosomes are observed to double and divide just before cell division.

<p>True (A)</p> Signup and view all the answers

What did Walter Sutton and Theodore Boveri note about the behavior of chromosomes?

<p>The behavior of chromosomes is parallel to the behavior of genes.</p> Signup and view all the answers

What phenotypic ratio is commonly derived from a dihybrid cross involving seed color and seed shape?

<p>9:3:3:1 (A)</p> Signup and view all the answers

Mendel's Law of Independent Assortment states that the segregation of one pair of alleles is dependent on the segregation of another pair.

<p>False (B)</p> Signup and view all the answers

How many different types of gametes are produced in a dihybrid cross involving RrYy?

<p>4</p> Signup and view all the answers

Based on Mendel's cross, the genotypes of the gametes can be expressed as ______.

<p>RY, Ry, rY, ry</p> Signup and view all the answers

Match the following genotype with its phenotype:

<p>RrYy = Round and yellow seeds RRYy = Round and yellow seeds rryy = Wrinkled and green seeds</p> Signup and view all the answers

Which of these statements correctly defines a dihybrid cross?

<p>A cross that studies two pairs of contrasting traits. (A)</p> Signup and view all the answers

Punnett squares can illustrate the segregation of alleles during meiosis.

<p>True (A)</p> Signup and view all the answers

What is the genotypic ratio in the F2 generation for a dihybrid cross?

<p>1:2:1:1:2:1:1:2:1</p> Signup and view all the answers

What does the Law of Independent Assortment state regarding gene inheritance?

<p>Different genes assort independently of one another. (A)</p> Signup and view all the answers

What is the primary purpose of a test cross in genetics?

<p>To identify the genotype of a plant showing dominant traits (A)</p> Signup and view all the answers

Sex-linked genes are located on autosomes.

<p>False (B)</p> Signup and view all the answers

What condition is caused by trisomy of chromosome 21?

<p>Down's syndrome</p> Signup and view all the answers

The Law of Segregation explains that alleles blend together during gamete formation.

<p>False (B)</p> Signup and view all the answers

In humans, a normal male has _____ pairs of autosomes and one pair of sex chromosomes.

<p>22</p> Signup and view all the answers

What ratio is typically observed among phenotypes in the F2 generation of a monohybrid cross?

<p>3:1</p> Signup and view all the answers

In a monohybrid cross, the traits of the ______ generation can express both parental traits.

<p>F2</p> Signup and view all the answers

Match the syndrome with its corresponding chromosomal condition:

<p>Down's syndrome = Trisomy 21 Turner's syndrome = XO genotype Klinefelter's syndrome = XXY genotype Sickle-cell anemia = Point mutation in hemoglobin gene</p> Signup and view all the answers

Which of the following describes point mutation?

<p>A change of a single base pair in DNA. (B)</p> Signup and view all the answers

Match each Law of Inheritance with its main principle:

<p>Law of Dominance = One trait will dominate another in a pair. Law of Segregation = Alleles segregate during gamete formation. Law of Independent Assortment = Different traits are passed independently. Law of Genetics = Inheritance occurs through discrete units called factors.</p> Signup and view all the answers

Linked genes assort independently during meiosis.

<p>False (B)</p> Signup and view all the answers

What is the outcome of a test cross between a tall plant (unknown genotype) and a dwarf plant?

<p>The offspring phenotype ratio indicates the genotype of the tall parent. (C)</p> Signup and view all the answers

According to Mendel's first law, the recessive trait is observed only in the F1 generation.

<p>False (B)</p> Signup and view all the answers

What is the primary method used to study inheritable mutations within families?

<p>Pedigree analysis</p> Signup and view all the answers

Flashcards

Alleles

Different forms of the same gene, responsible for variations in a trait like height.

Genotype

An organism's complete set of genes, represented by letters like TT, Tt or tt.

Phenotype

The observable characteristics of an organism, like tall or dwarf.

Homozygous

A pair of identical alleles for a trait, like TT or tt.

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Heterozygous

A pair of different alleles for a trait, like Tt.

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Dominant Allele

The allele that masks the expression of the other allele in a heterozygous pair.

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Recessive Allele

The allele whose expression is masked by the dominant allele in a heterozygous pair.

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Monohybrid Cross

A cross between two individuals with different alleles for a single trait, like tall and dwarf.

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F1 generation

The first filial generation (F1) resulting from a cross between two parental organisms with contrasting traits.

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F2 generation

Offspring produced by self-pollination of F1 individuals, resulting in the second filial generation.

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Dominance

A condition where one allele masks the expression of another allele for the same trait.

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True-breeding

A condition where both parents are true-breeding for a contrasting trait, meaning they produce offspring with the same trait as themselves.

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Fertilization

The process of uniting male gamete (pollen) with the female gamete (egg) to form a zygote.

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Punnett square

A diagram used to predict the possible genotypes and phenotypes of offspring from a cross between two parents.

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Sampling Size

The number of individuals in a study sample. A larger sample size generally leads to more reliable and generalizable results.

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Successive Generations

Repeated experiments using offspring of previous test subjects. This helps confirm the reliability and generalizability of results over generations.

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Contrasting Traits

A pair of contrasting characteristics within an organism, like tall/dwarf plants or yellow/green seeds.

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Pollination

The process where plants transfer pollen from the male part of the flower to the female part, resulting in fertilization and seed production.

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True-Breeding Line

A plant line that consistently produces offspring with the same trait over generations due to self-fertilization.

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Cross-Pollination

The intentional crossing of two different plant varieties to study the inheritance of specific traits.

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Artificial Pollination Experiments

Experimentation using artificial pollination to control and observe the inheritance of specific traits.

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Rules of Inheritance

Basic principles governing inheritance that describe how traits are passed from one generation to the next. It forms the foundation of modern genetics.

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Equivalent Allele

An allele that produces the same phenotype as the unmodified allele. They are responsible for maintaining traits within a population.

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Modified Allele

A change in an allele that can affect its functionality. These changes can lead to differences in gene expression and phenotypes.

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Modified Allele (Effect)

An allele that produces a non-functional or less efficient enzyme compared to the normal allele. This can lead to a different phenotype.

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Incomplete Dominance

A type of inheritance where the F1 generation exhibits a phenotype that is a blend of both parents, displaying a mix of both traits.

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Gene I

A special type of gene that controls ABO blood grouping in humans. It has three alleles, IA, IB, and i, each contributing to a specific blood group.

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Diploidy in ABO Blood Type

Two alleles are present in each individual, which can be any two of the three alleles (IA, IB, i) that determine ABO blood type.

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Dominance in ABO Blood Type

The alleles IA and IB are dominant over the i allele, resulting in the expression of the dominant allele's corresponding sugar when paired with the i allele.

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Co-dominance in ABO Blood Type

When both IA and IB alleles are present, both alleles express their respective sugars, resulting in a combination of A and B sugars.

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ABO Genotypes

The six possible combinations of the three ABO blood type alleles create six different genotypes (IAIA, IAi, IBIB, IBi, IAIB, ii).

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ABO Phenotypes

The four distinct blood types (A, B, AB, O) are the phenotypes of the ABO blood group system.

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Multiple Alleles: ABO Blood Group System

The ABO blood group system is an example of multiple alleles where more than two alleles exist for a single trait.

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Population Studies for Multiple Alleles

Multiple alleles are observed when analyzing a population, as individuals possess only two alleles for a trait.

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Pleiotropy: One Gene, Multiple Effects

A single gene can influence multiple traits. For example, the gene responsible for starch synthesis in peas affects both starch production and grain size.

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Polygenic Inheritance

A type of inheritance where multiple genes contribute to a single trait, resulting in a continuous range of phenotypes.

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Polygenic Traits

Traits controlled by three or more genes, resulting in a continuous range of possible phenotypes.

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Environmental Influence on Polygenic Traits

The influence of environmental factors on the expression of a polygenic trait.

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Pleiotropic Gene

A single gene that can influence multiple phenotypic traits.

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Phenylketonuria (PKU)

A condition caused by a mutation in the gene for the enzyme phenylalanine hydroxylase, leading to mental retardation and reduced pigmentation.

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Sex Determination

The biological process that determines the sex of an organism.

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Early Clues to Sex Determination

The initial clue about the genetic/chromosomal mechanism of sex determination was obtained from experiments conducted on insects.

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Chromosomal Sex Determination

The genetic/chromosomal mechanism of sex determination is based on specific chromosomes.

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DNA

The molecular blueprint that carries genetic information and is responsible for the inheritance of traits.

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Dog Flower Example

In a cross between true-breeding red (RR) and white (rr) flowers, the F1 generation (Rr) displays pink flowers, a blend of the parental colors.

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Heterozygous Phenotype

In incomplete dominance, the heterozygous genotype (Rr) produces a phenotype distinct from either homozygous genotype (RR or rr).

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F2 Phenotypic Ratio

In incomplete dominance, the F2 generation shows a 1:2:1 phenotypic ratio, unlike the typical 3:1 Mendelian ratio.

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Allele Dominance

Alleles are different forms of the same gene, responsible for variations in a trait. Some alleles are dominant, masking the effect of others.

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What is the F1 generation?

The first generation of offspring resulting from crossing two parent plants with contrasting traits. In the example described, this is the generation that is all tall plants.

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What is the F2 generation?

The second generation of offspring produced by self-pollination of F1 plants. In the example, this generation shows a 3:1 ratio of tall to dwarf plants.

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What is the Genotype of an organism?

The specific combination of alleles that an individual possesses for a particular trait, represented by letters. For example, TT, Tt, or tt.

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What is the Phenotype of an organism?

The physical characteristics that an organism exhibits as a result of its genotype. In the example, this refers to the height of the plant, either tall or dwarf.

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What is Dominance in Genetics?

A condition where one allele masks the expression of the other for the same trait. In Mendel's experiment, the 'tall' allele (T) is dominant over the 'dwarf' allele (t).

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What is a Recessive Allele?

An allele whose expression is masked by the dominant allele in a heterozygous pair. For instance, the 'dwarf' (t) allele is recessive to the 'tall' (T) allele.

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What is a Monohybrid Cross?

A cross between two individuals with different alleles for a single trait. In Mendel's peas, this is the cross between a true-breeding tall plant (TT) and a true-breeding dwarf plant (tt).

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What is the Phenotypic Ratio?

This refers to the observed ratio of phenotypes in the F2 generation. In Mendel's experiment, the phenotypic ratio was 3 tall : 1 dwarf.

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Chromosomal segregation

The separation of chromosomes during gamete formation, where each gamete receives only one chromosome from each pair.

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Independent assortment of chromosomes

The independent assortment of chromosomes during meiosis, where each pair of chromosomes separates independently of other pairs. This leads to different combinations of chromosomes in gametes.

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Chromosomal theory of inheritance

The idea that chromosomes are the carriers of genes and that the separation of chromosomes during meiosis explains the segregation of Mendelian factors.

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Drosophila melanogaster

A fruit fly species (Drosophila melanogaster) commonly used in genetic research. Its rapid life cycle, prolific offspring, and easily observable traits made it ideal for studying inheritance.

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Discovery of Chromosomes

Chromosomes (colored bodies) were discovered around 1900 due to advancements in microscopy techniques. These structures, visible by staining, were observed to duplicate and divide before each cell division.

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Allele Location

The two alleles of a gene pair are located at corresponding positions (loci) on homologous chromosomes.

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Meiosis and Germ Cell Formation

Meiosis is a type of cell division that reduces the number of chromosomes in a cell by half. This is how germ cells (sperm and egg) are formed, ensuring that the offspring inherit half of their chromosomes from each parent.

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Why Mendel's Work Was Ignored

Mendel's work on inheritance remained unrecognized for several years because of limited communication, his novel concept of genes and their stable nature, and his use of mathematics in biological explanations.

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Rediscovering Mendel

In 1900, three scientists independently rediscovered Mendel's work on inheritance, which led to renewed interest in his ideas.

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Mendel's Laws and Chromosome Behavior

Mendel's laws, which describe the patterns of inheritance, were explained by the behavior of chromosomes during meiosis. This helped solidify the connection between genes and chromosomes.

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Parallel Behavior of Chromosomes and Genes

The behavior of chromosomes during meiosis, including their segregation and independent assortment, parallels the behavior of genes during inheritance, providing evidence for the chromosomal theory of inheritance.

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Male Heterogamety

A system where the sex of offspring is determined by the type of sex chromosome present in the sperm.

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Female Heterogamety

A system where females produce two different types of gametes, one with a Z chromosome and the other with a W chromosome.

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Spermatogenesis

The process where males produce two different types of sperm, half with an X chromosome and half with a Y chromosome.

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Autosomes

The 22 pairs of chromosomes present in both males and females that are not involved in sex determination.

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Zygote

A fertilized egg cell that forms when a sperm cell and an egg cell fuse.

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Probability of Sex

The probability that a child will be born male or female, which is always 50% for each pregnancy.

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Blame for Female Children

The false belief that women are responsible for the sex of their children.

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What are mutagens?

Any agent that can cause a change in the DNA sequence, which can lead to mutations.

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What is a pedigree analysis?

A diagram that shows the inheritance pattern of a trait within a family across generations.

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How is pedigree analysis used?

The process of analyzing family history to understand how specific traits or disorders are passed down from generation to generation.

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What is a mutation?

A mutation is a permanent change that occurs in the DNA sequence of an organism. These changes can be harmful, beneficial, or have no effect.

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How can mutations occur?

Mutations can occur spontaneously due to errors in DNA replication or be induced by external factors like UV radiation.

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How does UV radiation cause mutations?

UV radiation, a mutagen, can damage DNA and cause mutations in organisms. This is why it's important to protect your skin from the sun.

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What is human genetics?

The study of inheritance patterns and traits in human beings is called human genetics. It helps us understand how diseases and other traits are passed down in families.

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Why is pedigree analysis important in human genetics?

Pedigree analysis is particularly useful in human genetics because controlled experiments like those done with plants are not ethically possible with humans.

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Haplodiploidy

A sex-determination system where males develop from unfertilized eggs (haploid) and females from fertilized eggs (diploid).

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Parthenogenesis

The process of a female egg developing into a viable offspring without fertilization.

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How do male honeybees develop?

Male honeybees (drones) are formed from unfertilized eggs, thus having half the number of chromosomes as females.

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Mutation

A change in the DNA sequence of an organism, potentially leading to alterations in genotype and phenotype.

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Point mutation

A type of mutation involving a change in a single base pair of DNA.

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Frameshift mutation

Mutations that involve the insertion or deletion of one or more base pairs in a DNA sequence, shifting the reading frame and potentially altering protein synthesis.

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Chromosomal aberration

Chromosomal aberrations are changes in the structure or number of chromosomes, often associated with diseases like cancer.

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How can a mutation lead to sickle cell anemia?

A type of mutation that affects the function of a gene, leading to a different phenotype, like sickle cell anemia.

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Sex Chromosomes

The chromosomes that determine the sex of an organism. In humans, these are the X and Y chromosomes.

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Y-chromosome

The sex chromosomes specific to males, typically smaller than the X chromosome.

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X-chromosome

The sex chromosomes specific to females, typically larger than the Y chromosome.

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Mendelian Disorders

Disorders caused by changes in a single gene, passed down in predictable patterns following Mendel's laws.

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Pedigree Analysis

A diagram that tracks the inheritance of traits through generations in a family.

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Color Blindness

A recessive sex-linked disorder caused by a defective gene on the X chromosome, leading to the inability to distinguish red and green colors.

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Pleiotropy

A condition where a single gene affects multiple traits or characteristics.

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Sickle-Cell Anemia

An example of a genetic disorder, caused by a mutation in the beta-globin gene, leading to abnormal hemoglobin and red blood cell shape.

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Klinefelter's Syndrome

A genetic disorder caused by the presence of an extra X chromosome (47, XXY), resulting in overall masculine development but also some feminine characteristics like breast development (Gynecomastia). Individuals with Klinefelter's Syndrome are sterile.

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Turner's Syndrome

A genetic disorder caused by the absence of one X chromosome (45, X0), resulting in sterile females with underdeveloped ovaries and lack of secondary sexual characteristics.

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Law of Segregation

The principle that explains how pairs of genes (alleles) separate during gamete formation, ensuring that each gamete receives only one allele from each pair.

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Law of Independent Assortment

The principle that states that during gamete formation, different pairs of genes (alleles) separate independently of each other, resulting in new combinations of alleles in offspring.

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Meiosis

The process of cell division that reduces the number of chromosomes in a cell by half, resulting in gametes (sperm and egg) with half the number of chromosomes as the parent cell.

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Test Cross

A cross between an organism with an unknown genotype and a homozygous recessive organism. This helps determine the unknown genotype by analyzing the offspring.

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Law of Dominance

This law explains that when two different alleles are present for a trait, the dominant allele is expressed, masking the recessive allele.

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Mutation (Effect)

A type of mutation that affects the function of a gene, leading to a different phenotype.

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What is a Punnett Square?

A tabular representation predicting the genotypes and phenotypes of offspring from a cross between two parents.

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What is Fertilization?

The process of uniting male gamete (pollen) with the female gamete (egg) to form a zygote.

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What is a Phenotype?

The observable characteristics of an organism resulting from its genotype, like tall or dwarf plants.

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What is a Genotype?

The specific combination of alleles possessed by an organism for a trait.

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Down Syndrome

A disorder in which an individual has three copies of chromosome 21, leading to mental and physical challenges.

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Linkage

Genes located on the same chromosome tend to be inherited together due to their physical association.

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Recombination

The process of producing new combinations of genes on a chromosome, leading to offspring with traits different from either parent.

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Gene Mapping

The frequency of recombination between two genes on the same chromosome is used to estimate the distance between them.

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Dihybrid Cross with Linked Genes

A dihybrid cross involving two linked genes deviates significantly from the expected 9:3:3:1 ratio, indicating that the genes are not inherited independently.

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Tight vs. Loose Linkage

Tightly linked genes show very low recombination frequencies, while loosely linked genes exhibit higher recombination frequencies.

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Morgan's Drosophila Experiments

Morgan's experiments with fruit flies (Drosophila melanogaster) provided crucial insights into the concept of linked genes and their inheritance.

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Sturtevant's Gene Mapping

Variations in the frequency of recombination between gene pairs on the same chromosome helped Sturtevant map the relative positions of genes.

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Genome Sequencing

Genetic maps are used as starting points for sequencing entire genomes, providing insights into the organization of DNA.

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What is Klinefelter's Syndrome?

A genetic condition where a person has an extra X chromosome, resulting in a karyotype of 47, XXY. Individuals with Klinefelter's Syndrome typically have overall masculine development but may also experience some feminine characteristics, such as breast development (Gynecomastia). This condition leads to sterility.

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What is Turner's Syndrome?

A genetic disorder caused by the absence of one X chromosome, resulting in a karyotype of 45, X0. Individuals with Turner's Syndrome are female but typically have underdeveloped ovaries and lack secondary sexual characteristics. This leads to sterility.

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What is Chromosomal Sex Determination?

The process of sex determination is influenced by specific chromosomes in an organism. This means that the combination of sex chromosomes, like X and Y in humans, dictates the sex of an individual.

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What is Pollination?

The process of transferring pollen from the male part of the flower to the female part, leading to fertilization and seed production. This is a critical step in plant reproduction.

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Cross-Pollination Experiments

Mendel intentionally crossed different pea varieties to study how specific traits were passed down to offspring.

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Artificial Pollination

Mendel's experiments involved manipulating pollination to control which plants bred together. This ensured precise observation of inheritance.

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Large Sample Size and Successive Generations

Mendel's studies were significant due to his large sample size and repeated experiments across generations, enhancing the credibility of his findings.

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Mendel's Work Ignored

Mendel's work was largely ignored for many years due to his novel ideas and the lack of widespread scientific recognition.

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What is a test cross?

A cross between an organism with an unknown genotype (dominant phenotype) and a homozygous recessive organism. This helps determine the unknown genotype by analyzing the offspring.

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What is the Law of Segregation?

Principle explaining how a pair of factors (alleles) responsible for a trait separate during gamete formation, with each gamete receiving only one factor from the pair.

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What is the Law of Dominance?

One of Mendel's Laws, stating that for a particular trait, one factor (allele) masks the effect of the other (recessive) factor. This explains the dominant 3:1 phenotypic ratio in F2 generation.

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Gene Segregation

Genes also occur in pairs and segregate during gamete formation. However, only one allele from each pair is transmitted to a gamete. Each gene pair segregates independently of other gene pairs.

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Sutton-Boveri Hypothesis

Sutton and Boveri argued that chromosome pairs split during gamete formation, leading to the separation of the factors they carried, later identified as genes.

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Independent Assortment and Variation

The independent assortment of chromosomes during meiosis I explains the variation in offspring traits. The random alignment and separation of chromosome pairs generate different combinations of chromosomes and hence different combinations of alleles.

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Gene Location on Chromosomes

The two alleles of a gene pair are located at corresponding positions (loci) on homologous chromosomes.

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Meiosis and Mendelian Inheritance

The pairing and separation of chromosomes during meiosis underlies Mendelian inheritance patterns. This provides crucial evidence for the chromosomal theory of inheritance.

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Inheritance

The passing of traits from parents to offspring.

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Dominance: Dependent on Gene Product and Phenotype

The dominance of an allele is not a fixed property. It depends on the specific gene product and the chosen phenotype for examination. For instance, in pea plants, the B allele for seed shape can be dominant for roundness but incompletely dominant for starch grain size.

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Heterozygous Phenotype in Incomplete Dominance

In incomplete dominance, the heterozygous genotype produces a phenotype distinct from either homozygous genotype. For example, in a red flower crossed with a white flower, the heterozygous offspring exhibits pink flowers.

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F2 Phenotypic Ratio in Incomplete Dominance

The F2 generation in incomplete dominance shows a 1:2:1 phenotypic ratio, unlike the typical 3:1 Mendelian ratio. This pattern arises because the heterozygous phenotype is unique and distinct from either homozygous phenotype.

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Trisomy

A situation where an individual has an extra copy of a specific chromosome, resulting in three copies instead of the usual two.

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Monosomy

A situation where an individual lacks one copy of a specific chromosome from a pair.

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What is the total number of chromosomes in a normal human cell?

The total number of chromosomes present in a normal human cell.

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Linkage and its effect on inheritance

The phenomenon where two or more genes located on the same chromosome do not segregate independently during meiosis. This leads to the inheritance of parental gene combinations more frequently than non-parental combinations.

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Tightly vs. Loosley linked genes

The observation that some genes on the same chromosome show very low recombination while others show higher recombination. This indicates the relative distance between genes; tightly linked genes are closer, and loosely linked genes are farther apart.

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Thalassemia

A genetic blood disorder caused by a mutation or deletion in the genes responsible for producing globin chains, leading to abnormal hemoglobin and anemia.

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Alpha Thalassemia

A type of thalassemia where the production of alpha globin chains is affected.

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Beta Thalassemia

A type of thalassemia where the production of beta globin chains is affected.

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Polyploidy

A condition where an organism has an extra set of chromosomes.

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Aneuploidy

A condition where an organism has an abnormal number of chromosomes, usually due to the loss or gain of one or more chromosomes.

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Henking's 'X body'

A specific nuclear structure observed during spermatogenesis in insects. Henking named it the 'X body' but its significance wasn't understood then.

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XO insects

Insects that use the XO system of sex determination. Females have two X chromosomes while males have only one.

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What are alleles?

Genes coding for contrasting traits, like tall vs. dwarf, are called alleles.

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What is homozygous?

When both alleles for a trait are the same, like TT or tt, it's called homozygous.

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What is heterozygous?

When the two alleles for a trait are different, like Tt, it's called heterozygous.

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What is a dominant allele?

The allele that masks the expression of the other in a heterozygous pair is called the dominant allele.

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Recombination Frequency

The measure of the distance between two linked genes on a chromosome, calculated based on the frequency of recombination between them.

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Genetic Map

A map that shows the relative positions of genes on a chromosome, determined by recombination frequencies.

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Gene Linkage

The physical association of genes on a chromosome, which influences their inheritance pattern.

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Crossing Over

The process of crossing over between homologous chromosomes during meiosis, leading to the exchange of genetic material and the creation of recombinant chromosomes.

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Non-Parental Gene Combinations

The frequency of non-parental gene combinations in offspring, indicating the degree of recombination between linked genes.

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Physical Map

A type of chromosome map that shows the physical distance between genes on a chromosome, measured in base pairs or kilobase pairs.

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What is a polygenic trait?

A trait controlled by three or more genes, resulting in a wide range of variation, not just two distinct categories. Think of human height - not just tall or short, but a whole spectrum.

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What is pleiotropy?

A single gene influencing multiple phenotypic traits. Imagine a gene affecting both flower color and petal shape.

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What is sex determination?

The process determining the sex of an organism. In humans, it's determined by the presence of X and Y chromosomes.

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What is additive inheritance?

A type of inheritance where the effect of each allele controlling a trait (like skin color) adds up to influence the overall phenotype. Think of building a tower - each block contributes.

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Explain Pleiotropy

The inheritance pattern where a single gene influences multiple phenotypic traits. An example is phenylketonuria (PKU) which affects both mental development and pigmentation.

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Define Polygenic inheritance

This describes the process of inheritance where multiple genes contribute to a single trait, leading to a continuous variation in phenotype. Think of human height: many genes contribute to the spectrum of heights.

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Explain chromosomal sex determination

The genetic mechanism responsible for sex determination involves specific chromosomes. For example, in humans, females have two X chromosomes (XX), while males have one X and one Y chromosome (XY).

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Define Pleiotropy

A condition where a single mutated gene leads to multiple phenotypic effects. For example, phenylketonuria (PKU) affects both mental development and skin pigmentation.

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What does Homozygous mean?

A pair of identical alleles for a particular trait. For example, 'TT' represents homozygous tall and 'tt' represents homozygous dwarf.

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What does Heterozygous mean?

A pair of different alleles for a particular trait. For example, 'Tt' represents heterozygous tall.

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Factors

These units, called factors, are the basic units of inheritance responsible for controlling specific traits. They are now known as genes.

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Factors Occur in Pairs

The alleles for a particular trait occur in pairs, one from each parent. This ensures that each offspring receives two alleles, one from each parent.

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Why was Mendel's work ignored?

Mendel's ideas about inheritance remained unrecognized for many years due to several factors, including poor communication, resistance to his concept of discrete genes, and his novel use of mathematics in biological explanations.

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Sutton and Boveri's Contribution

Walter Sutton and Theodore Boveri proposed that chromosome movement during meiosis explains Mendel's laws. This marked a major breakthrough in understanding inheritance.

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Dihybrid Cross

A cross between two individuals differing in two pairs of contrasting traits.

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Mendel's Law of Independent Assortment

A generalisation that states when two pairs of traits are combined in a hybrid, segregation of one pair of characters is independent of the other pair of characters.

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Genotypic Ratio

The ratio of different genotypes observed in the offspring of a cross, often expressed as numerical proportions.

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Segregation of Alleles

The separation of alleles during gamete formation, ensuring each gamete receives only one allele from each pair.

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Henking's Experiment on Sex Determination

The process of tracing a specific nuclear structure (X body) throughout the stages of sperm development, observed by Henking in insects, where half of the sperm received the structure and the other half did not.

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Female Offspring Development

The process of fertilization where an egg is fertilized by sperm with an X chromosome, resulting in a female offspring.

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Male Offspring Development

The process of fertilization where an egg is fertilized by sperm without an X chromosome, resulting in a male offspring.

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Study Notes

Summary of Genetics

  • Genetics is the study of inheritance and variation of traits.
  • Traits are characteristics passed from parents to offspring.
  • Variation describes how offspring differ from their parents.

Mendel's Laws of Inheritance

  • Inheritance patterns were studied using pea plants.
  • Dominant traits mask recessive traits in the first filial generation (F1).
  • Recessive traits reappear in the second filial generation (F2).
  • Law of Dominance: One trait masks the other in the F1, for example, the tall trait masks the short trait.
  • Law of Segregation: Alleles separate during gamete formation.
  • Law of Independent Assortment: Alleles of different traits segregate independently, for example, seed color and seed shape independently segregate.

Incomplete Dominance

  • The F1 generation exhibits a blending of traits, for example, crossing a red flower with a white flower results in pink flowers.
  • The resulting phenotypes blend, the blended traits are intermediate in characteristics, for example, in snapdragon.
  • The heterozygous phenotype is not identical to either homozygous phenotype.
  • Example of incomplete dominance: Snapdragon flower color.

Co-dominance

  • Both traits are expressed in the F1 generation, for example, ABO blood groups; A and B alleles are both expressed if present, resulting in the AB blood type.
  • Example: ABO blood groups.
  • Co-dominance: Both alleles are fully expressed in the phenotype.

Sex Determination

  • Humans have 23 pairs of chromosomes, 22 pairs are autosomes, one pair are sex chromosomes.
  • Males have XY chromosomes.
  • Females have XX chromosomes.
  • In some organisms like birds, the female has ZW chromosomes, and males have ZZ chromosomes.
  • Gene products influence the expression of traits.
  • Sex determination mechanisms exist in different species (e.g., XO, XY, ZW).
  • In Honeybees, sex is determined by whether the egg is fertilized.
  • Example of sex determination: Honey bee; diploid females, haploid males.

Mutations

  • Mutations are changes in DNA sequence that can alter traits.
  • They can be caused by environmental factors or errors in DNA replication.
  • There are many types of mutations, including substitutions, insertions, and deletions.

Genetic Disorders

  • Genetic disorders arise from mutations altering DNA.
  • Examples include:
    • Down Syndrome (trisomy 21).
    • Sickle-cell anemia (caused by a substitution of an amino acid in the hemoglobin protein).
    • Haemophilia (sex-linked recessive trait).
    • Phenylketonuria (lack of an enzyme that converts phenylalanine into tyrosine).
    • Thalassemia (deficient globin production leading to abnormal hemoglobin resulting in anemia).
  • These can result from abnormalities in chromosome number or structure (e.g., an extra chromosome, missing chromosome).
  • Examples of chromosomal disorders include Klinefelter's syndrome (XXY) and Turner's syndrome (XO).
  • Other examples include phenylketonuria, thalassemia, and color blindness (sex-linked, recessive).
  • Mutations can lead to altered gene products, which causes various disorders.
  • Genetic disorders can be caused by mutations in a single gene or multiple genes, or by changes in chromosome structure or number.
  • Pedigree analysis is used to study patterns of inheritance of genetic traits in families.
  • Examples of Genetic Disorders based on their inheritance patterns:
    • Autosomal dominant disorders; Myotonic dystrophy.
    • Autosomal recessive disorders; Sickle-cell anemia.
    • Sex-linked recessive disorders; Colour blindness, haemophilia.
  • Other disorders include Klinefelter syndrome, Turner syndrome.
  • Genetic disorders can be caused by mutations in a single gene or multiple genes, or by changes in chromosome structure or number.

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