Podcast
Questions and Answers
What happens when a single base pair insertion occurs in an mRNA sequence?
What happens when a single base pair insertion occurs in an mRNA sequence?
Which amino acid has the most number of codons specifying it?
Which amino acid has the most number of codons specifying it?
How many of the 64 possible codons signal chain termination?
How many of the 64 possible codons signal chain termination?
In what orientation do mRNA codons pair with tRNA anticodons?
In what orientation do mRNA codons pair with tRNA anticodons?
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What is the main reason for redundancy in the genetic code?
What is the main reason for redundancy in the genetic code?
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Which of the following is true about the genetic code?
Which of the following is true about the genetic code?
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What are the three main stages of bacterial protein synthesis?
What are the three main stages of bacterial protein synthesis?
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What did Francis Crick propose in his adaptor hypothesis?
What did Francis Crick propose in his adaptor hypothesis?
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Which of the following is NOT a property of the genetic code?
Which of the following is NOT a property of the genetic code?
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What does a non-overlapping code mean in the context of the genetic code?
What does a non-overlapping code mean in the context of the genetic code?
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How many different aminoacyl tRNA synthetases are there?
How many different aminoacyl tRNA synthetases are there?
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What does 'degenerate' mean in relation to the genetic code?
What does 'degenerate' mean in relation to the genetic code?
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What role do tRNAs play in protein synthesis?
What role do tRNAs play in protein synthesis?
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What is the function of ribosomes in protein synthesis?
What is the function of ribosomes in protein synthesis?
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Which statement about the genetic code is correct?
Which statement about the genetic code is correct?
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Which process requires a large number of tRNA molecules?
Which process requires a large number of tRNA molecules?
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Study Notes
The Genetic Code
- A single base pair insertion alters the reading frame, resulting in a different sequence of amino acids
- The genetic code is degenerate, meaning that there is redundancy but no ambiguity
Codon Properties
- Codons are written in the 5'-3' direction
- The 3rd base is less important in codon reading
- Only Met and Trp have a single codon
- Some codons are more abundant than others due to the availability of tRNAs
mRNA Codons and tRNA Anticodons
- The codon sequence is complementary to the anticodon sequence
- The codon in mRNA base pairs with the anticodon in tRNA via hydrogen bonding
- The alignment of two RNA segments is antiparallel
Key Points of the Genetic Code
- Each of the 20 amino acids in proteins is specified by one or more nucleotide triplets in mRNA
- Of the 64 possible triplets, 61 specify amino acids and 3 signal chain termination
- The code is non-overlapping, with each nucleotide part of a single codon
- The genetic code is nearly universal, with the 64 triplets having the same meaning in all organisms
Protein Synthesis
- Protein synthesis occurs in a large macromolecular assembly called the ribosome
- The process involves many proteins and several RNA molecules
- It uses a large number of tRNAs that interact with mRNA
- Each tRNA is charged with one of the 20 common amino acids by 20 different aminoacyl tRNA synthetases
The Triplet Code
- The genetic code is a non-overlapping code, meaning that a sequence of three nucleotides can only be read once
- This is in contrast to an overlapping code, where a sequence of three nucleotides can be read more than once
Antibiotics and Protein Synthesis
- Antibiotics target ribosome sites during bacterial protein synthesis
- The process of protein synthesis in bacteria can be divided into three stages: initiation, elongation, and termination
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Description
Learn about the genetic code, its properties, and how codons and tRNA anticodons work together. Understand the impact of base pair insertions and the redundancy of the genetic code.