Podcast
Questions and Answers
What genetic inheritance pattern is predominantly seen in familial Alzheimer's Disease (FAD)?
What genetic inheritance pattern is predominantly seen in familial Alzheimer's Disease (FAD)?
- Completely independent of genetic inheritance
- Only recessive inheritance
- Only dominant inheritance
- A combination of both dominant and recessive inheritance (correct)
What happens if an individual inherits a mutant gene from either parent regarding early-onset Alzheimer's Disease?
What happens if an individual inherits a mutant gene from either parent regarding early-onset Alzheimer's Disease?
- They will definitely develop early-onset AD (correct)
- They will have a 25% chance of developing AD
- They will develop late-onset AD instead
- They will not develop AD regardless of the other parent’s genes
What distinguishes early-onset Alzheimer's Disease from late-onset in terms of genetic mutations?
What distinguishes early-onset Alzheimer's Disease from late-onset in terms of genetic mutations?
- Only healthy carriers can develop early-onset AD
- All early-onset mutations are recessive
- Late-onset AD is never influenced by genetics
- Early-onset mutations often involve dominant genes (correct)
In the context of familial Alzheimer's Disease, what is true about carriers of a recessive mutant gene?
In the context of familial Alzheimer's Disease, what is true about carriers of a recessive mutant gene?
What mechanism causes the rapid accumulation of beta-amyloid in early-onset Alzheimer's Disease?
What mechanism causes the rapid accumulation of beta-amyloid in early-onset Alzheimer's Disease?
Flashcards
Familial Alzheimer's Disease (FAD)
Familial Alzheimer's Disease (FAD)
A rare form of Alzheimer's Disease (AD) that is caused by an inherited genetic mutation. Early-onset FAD is a more aggressive form of AD that leads to faster cognitive decline.
Mutant Gene
Mutant Gene
A gene variant that leads to an increased risk of developing Alzheimer's Disease. This can happen due to mutations, where a gene is copied incorrectly, or inherited genetic variations.
Dominant Gene
Dominant Gene
A gene that is expressed even if only one copy of the gene is inherited. This means that only one parent needs to pass on the gene for the effect to be seen.
Recessive Gene
Recessive Gene
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Early-Onset AD
Early-Onset AD
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Study Notes
Genetic Component of Alzheimer's Disease (AD)
- Familial AD is rare but presents similar brain effects to typical AD.
- Rapid beta-amyloid accumulation in familial AD is linked to genetic mutations that cause abnormal proteins associated with amyloid plaques.
- Humans have 23 pairs of chromosomes, one from each parent.
- Early-onset AD differs from late-onset AD in genetic patterns.
Early-Onset vs. Late-Onset AD
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Often, a dominant gene is responsible for early-onset AD.
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Genetic mutations occur when genes are copied incorrectly.
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Dominant genes express their effects (phenotype) even if only one copy is mutant.
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Recessive genes only express their effects if both copies of the gene are faulty. Individuals with one faulty copy are carriers.
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Familial AD follows a unique pattern and is linked to mutations in three specific genes.
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Inheritance of a mutant gene from either parent results in early-onset AD.
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The chance of inheriting a mutant gene from one parent is 50%, resulting in a 50% chance of developing early AD.
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Description
Explore the genetic components of Alzheimer's Disease, focusing on familial and sporadic cases. This quiz highlights key differences in early-onset and late-onset AD, including the role of dominant and recessive genes. Test your knowledge on how mutations affect the development of this complex disease.
