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Questions and Answers
What type of changes occur in the chromosomes during aberrations?
What type of changes occur in the chromosomes during aberrations?
- Duplication of centromeres
- Mutation of gene expression
- Deletion of small chromosomes
- Breakage and loss of large chromosomes (correct)
What is the correlation between the frequency of aberrations and radiation?
What is the correlation between the frequency of aberrations and radiation?
- The frequency of aberrations is independent of radiation
- The frequency of aberrations correlates well with the cytotoxic effects of radiation (correct)
- The frequency of aberrations decreases with increased radiation
- The frequency of aberrations is higher in the absence of radiation
What is the result of aberrations in terms of genetic material distribution?
What is the result of aberrations in terms of genetic material distribution?
- Unequal distribution of genetic material in daughter cells (correct)
- Duplication of genetic material in daughter cells
- Equal distribution of genetic material in daughter cells
- Loss of all genetic material in daughter cells
What type of cytotoxic effects are correlated with the frequency of aberrations?
What type of cytotoxic effects are correlated with the frequency of aberrations?
What is a characteristic feature of aberrations?
What is a characteristic feature of aberrations?
What is the main composition of a cell?
What is the main composition of a cell?
What can be affected by the repetition of these cellular deviations?
What can be affected by the repetition of these cellular deviations?
What is the similarity between a cell and the human body?
What is the similarity between a cell and the human body?
What is the result of the cellular deviations mentioned in the passage?
What is the result of the cellular deviations mentioned in the passage?
What is the context in which the cellular deviations are mentioned?
What is the context in which the cellular deviations are mentioned?
What can happen to the fragments that do not harm the cell?
What can happen to the fragments that do not harm the cell?
What is the result of the combination of some fragments?
What is the result of the combination of some fragments?
What is an example of a toxic substance that can be formed by the combination of fragments?
What is an example of a toxic substance that can be formed by the combination of fragments?
What can the formed toxic substances contribute to?
What can the formed toxic substances contribute to?
What is the outcome of the reaction between the fragments and other substances like water?
What is the outcome of the reaction between the fragments and other substances like water?
What is the primary component of a cell's volume?
What is the primary component of a cell's volume?
Why is there a higher probability of radiation interacting with the cell?
Why is there a higher probability of radiation interacting with the cell?
What is the significance of water in a cell's structure?
What is the significance of water in a cell's structure?
What is the likely consequence of radiation interacting with the water in a cell?
What is the likely consequence of radiation interacting with the water in a cell?
What is the proportion of water in a typical cell?
What is the proportion of water in a typical cell?
What is the direct result of Hydrogen Peroxide (H2O2) on the cell?
What is the direct result of Hydrogen Peroxide (H2O2) on the cell?
What is the indirect effect of Radiation on the cell?
What is the indirect effect of Radiation on the cell?
What is the consequence of DNA damage on the cell?
What is the consequence of DNA damage on the cell?
What is the type of damage caused by Free radicals to the cell?
What is the type of damage caused by Free radicals to the cell?
What is the direct effect of Radiation on the cell?
What is the direct effect of Radiation on the cell?
Study Notes
Chromosomal Aberrations
- These aberrations do not allow for equal distribution of genetic material in new cells.
- They can involve changes such as centric fusions and large chromosomal deletions.
Radiation Effects
- The frequency of chromosomal aberrations correlates well with the cytotoxic effects of radiation in many cases.
- Radiation interacts with water, which makes up most of the cell's volume, leading to a higher probability of radiation interaction.
Radiation Interaction with Water
- Water can form toxic substances, such as hydrogen peroxide (H2O2), when interacting with radiation.
- These toxic substances can contribute to cell destruction.
Direct and Indirect Radiation Effects
- Direct action: radiation directly causes DNA damage.
- Indirect action: radiation leads to the formation of free radicals, which then cause DNA damage.
Consequences of Radiation Exposure
- DNA damage can lead to cell death.
- Free radicals can cause DNA damage, leading to cell death.
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Description
Quiz about genetic aberrations, including chromosomal changes and deletion, and their correlation with radiation effects.